Tomoyuki Nomura

Niigata University, Niahi-niigata, Niigata, Japan

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Publications (5)3.26 Total impact

  • Hitoshi Okumura · Kojiro Ishioka · Hiroko Ueda · Tomoyuki Nomura ·
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    ABSTRACT: Objective: We report a retrospective study of 10 patients with a clinical diagnosis of granulomatosis with polyangiitis (GPA). Methods: The subjects were 10 patients who consulted our department between April 2003 and March 2011, and were diagnosed with GPA. We investigated the presence or absence of GPA-specific findings on CT of paranasal sinus and nasal mucosal biopsy. Results: CT findings of paranasal sinus in all patients: CT revealed bilateral paranasal bone thickening/destruction or mass formation in 5 patients. These findings differed from those of typical sinusitis. Biopsies from the nasal mucosa in six patients: In patients without abnormal intranasal findings, biopsy was conducted from the mucosa in an area adjacent to a paranasal shadow on CT. In 4 (67%) of the 6 patients, GPA was diagnosed. In 2 patients, a diagnosis was made based on nasal mucosal biopsy in an area in which inspection did not show any abnormalities. In 1 of these, it was impossible to perform invasive examinations due to deterioration of kidney function and general malaise. In the other, hypoxemia occurred immediately before thoracoscope-guided biopsy, which had been scheduled, making biopsy difficult. Furthermore, the two patients were negative for PR3-ANCA. Conclusions: Bilateral paranasal bone thickening/destruction or mass formation differ from those of typical sinusitis, and may be useful for the diagnosis of GPA. Biopsy of the nasal mucosa in the absence of abnormal intranasal findings may be useful for diagnosis. In particular, when several complications make invasive tests impossible, this examination should be performed.
    01/2015; 54(1):7-12. DOI:10.7248/jjrhi.54.7
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    ABSTRACT: BCL11B/CTIP2 zinc-finger transcription factor is expressed in various types of cells in many different tissues. This study showed that BCL11B is expressed in the nucleus of the outer hair cells of the mouse cochlea, degeneration of which is known to cause deafness and presbycusis or age-related hearing loss (AHL). We tested whether or not Bcl11b heterozygosity would affect AHL in mice. Analysis of auditory brainstem responses revealed AHL in Bcl11b (+/-) heterozygous, but not wild-type, mice, which was evident as early as 3 months after birth. Histological abnormalities were observed in the outer hair cells of the Bcl11b (+/-) mice at 6 months of age with hearing loss. These results suggest that the AHL observed in Bcl11b (+/-) mice is the result of impairment of the outer hair cells and that BCL11B activity is required for the maintenance of outer hair cells and normal hearing.
    Experimental Animals 01/2011; 60(4):355-61. DOI:10.1538/expanim.60.355 · 0.97 Impact Factor
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    ABSTRACT: We report two cases of intraoperative computer-aided surgery using magnetic resonance imaging (MRI)/computed tomography (CT) fusion imaging for inverted papilloma (IP). Case 1: IP had spread to the frontal recess/sinus so we chose a combined endoscopic sinus surgery (ESS) and external approach. Case 2: For a maxillary sinus tumor, we combined ESS and the adjuvant external (Caldwell-Luc) procedure. This is helpful to surgeons when, shifting fusion imaging when opening the frontal sinus bone to obtain CT data, and shifting to MRI to detect the tumor pedicle, then approaching the bone defect using MRI-CT fusion imaging (50-50%).
    Nippon Jibiinkoka Gakkai Kaiho 01/2010; 113(1):15-9. DOI:10.3950/jibiinkoka.113.15
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    ABSTRACT: Isolated sphenoid sinusitis is rare and difficult to diagnose. The difficulty arises because it is located in the deepest part of the nasal sinuses and the associated inflammation does not lead to typical symptoms of sinusitis. There are many important structures in the vicinity of the sphenoid sinus: the internal carotid artery, cavernous sinus and cranial nerves. Therefore, sphenoid sinusitis causes severe complications. From January 2003 to December 2007, we encountered 15 patients with isolated sphenoid sinusitis. Its incidence in all sinus diseases is 2. 2%. Many patients complain of headaches, and they often visit neurologists or neurosurgeons. The pathological spectrum included 10 cases of bacterial sinusitis (5 acute sinusitis, 3 chronic sinusitis and 2 asymptomatic sinusitis), 3 fungal sinusitis, 1 mucocele and 1 retention cyst. When we diagnose isolated sphenoid sinusitis, CT and endoscopy are essential. CT becomes a more useful tool for performing a differential diagnosis when we independently change the window height and width. The endoscopic findings regarding draining from the sphenoethmoidal recess may indicate the severity of inflammation. A detailed observation with CT and endoscopy is the most important to accurately diagnose the pathology of isolated sphenoid sinusitis.
    07/2009; 102(7):565-569. DOI:10.5631/jibirin.102.565
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    ABSTRACT: A region in the vicinity of D17Mit119 on mouse chromosome 17 harbors a susceptibility gene, designated as Ahl3, to age-related hearing loss (AHL). We produced congenic lines of C57BL/6 background that substituted regions around D17Mit119 with MSM-derived ones, and examined auditory brainstem response (ABR) thresholds for their hearing capacity at 6 and 12months of age. Three congenic lines carrying the approximately 14-Mb region between D17Mit274 and D17Mit183 retained normal hearing at 12months of age whereas two congenic lines not carrying this region tended to lose hearing at that age. We also investigated noise-induced hearing loss (NIHL) in congenic lines at 1, 7 and 14days after exposure to the noise of 100dB for 1h. Most congenic mice carrying the 14-Mb region did not exhibit permanent threshold shift (PTS) whereas mice not carrying this region exhibited a strong tendency of PTS, indicating the role of Ahl3 in susceptibility to NIHL. These results indicate that Ahl3 exists within the 14-Mb region and affects not only AHL but also NIHL.
    Biochemical and Biophysical Research Communications 04/2007; 355(1):117-21. DOI:10.1016/j.bbrc.2007.01.115 · 2.30 Impact Factor