Chai-Ming Lu

Tajen University, P’ing-tung-chieh, Taiwan, Taiwan

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Publications (1)1.56 Total impact

  • Source
    Lean-Teik Ng, Chun-Ching Lin, Chai-Ming Lu
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    ABSTRACT: In the search for potential antioxidants, the naphthalenic compounds, 6-methoxysorigenin (2) and its glycosides [i.e. 6-methoxysorigenin-8-O-glucoside (3), alpha-sorinin (4), and 6-methoxysorigenin-8-rutinoside (5)] isolated from Rhamnus nakaharai together with two acylates (peracetate and perpropionate) of 2 were evaluated for antioxidant activities using 2,2-diphenyl-1-picrylhydrazyl (DPPH), metal chelating, and electron spin resonance (ESR) assays as well as anti-lipid peroxidation assay. The results showed that 2 possesses the most potent DPPH radical scavenging, metal chelating, and anti-lipid peroxidation activities with IC50 values of 3.48, 615.90, and 5.95 microg/ml, respectively. The glycosides 3, 4, and 5 showed decreasing antioxidant activity that was related to an increased substitution at 1,8-dihydroxyl with sugar molecules. This suggests the importance of 1,8-dihydroxyl of 2 in the antioxidative effect. The iron chelation result could further explain the main cause of increasing antioxidant activity in 2. The acylates of 2 (2a peracetate and 2b perpropionate), although lacking a free hydroxyl, also exhibited significant anti-lipid peroxidation effect. ESR results further demonstrated that 2 possesses strong antioxidant activities. Taken together, this study shows that 2 is a potent antioxidant and may also be used for designing new iron chelators for clinical applications.
    CHEMICAL & PHARMACEUTICAL BULLETIN 04/2007; 55(3):382-4. · 1.56 Impact Factor

Publication Stats

2 Citations
1.56 Total Impact Points

Institutions

  • 2007
    • Tajen University
      • Department of Biotechnology
      P’ing-tung-chieh, Taiwan, Taiwan