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ABSTRACT: KeywordsQuality control-Quality assurance-Nuclear medicine instrumentation-Gamma camera-SPECT-PET-CT-Radionuclide calibrator-Thyroid uptake probe-Nonimaging intraoperative probe-Gamma counting system-Radiation monitors-Preclinical PET
European Journal of Nuclear Medicine 03/2010; 37(3):662-71. · 4.53 Impact Factor
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ABSTRACT: To present a method for calculating split renal function solely from routine triphasic helical computed tomography (CT).
We retrospectively included 26 adult patients who received renal scintigraphy and triphasic CT within 4 weeks in the years 2003 and 2004. All scans were performed using a standard abdominal protocol. Split renal function was calculated as relative single-kidney glomerular filtration rate (GFR) using a simplified "two-point Patlak plot" technique. As a reference method, split renal function was determined from renal scintigraphy using the standard technique.
Linear correlation between the two methods was r=0.91, split renal function (CT)=0.0266+0.9573 x split renal function (scintigraphy).
Split renal function can be measured accurately by minimally extended triphasic CT.
European Journal of Radiology 03/2007; 61(2):303-9. · 2.61 Impact Factor
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ABSTRACT: To evaluate the effect of dose rate on the therapeutic success of radioiodine therapy (RIT) by retrospective analysis of two groups of patients with different dose rates during RIT.
The average dose rate until deposition of 50% of the total radiation dose achieved (the DL50 value) was calculated. Ninety patients with autonomy of the thyroid receiving radiation doses between 300 and 400 Gy were separated in groups with high DL50 values (the DL50 H group) and low DL50 values (the DL50L group). Before and 4 months after RIT free triiodothyronine (FT3), free thyroxine (FT4), basal thyroid stimulating hormone (TSHB), stimulated TSH (TSHS), thyroidal technetium uptake (TcTU), and the existence of focal abnormalities in thyroid scintigraphy were evaluated.
The DL50 H and DL50L groups showed no differences before RIT in the parameters assessed as well as in total achieved dose and autonomous thyroid volume. After therapy a significant difference was found in TSHB with higher values in DL50 H (1.89+/-1.49 vs. 1.31+/-1.48 mU . l, P<0.05), FT4 showed a trend to lower values (13.8+/-4.0 vs. 16.1+/-6.2 pmol . l, P=0.09).
The DL50 value has an influence on therapeutic success of RIT. This influence is only discrete and not likely to produce clinically relevant effects in the practical use of RIT.
Nuclear Medicine Communications 08/2005; 26(8):727-30. · 1.40 Impact Factor
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ABSTRACT: Immunoscintigraphy with the use of the antigranulocyte antibody BW 250/183 is a reliable method for detecting infection, especially in septic loosening of hip prostheses, for which purpose quantitative interpretation of the time-activity course is employed. Therefore, we retrospectively studied whether similar results could be achieved in knee prostheses. We verified 28 scintigraphic examinations in 26 patients by histology. Scintigraphy was performed during an early (4-6 h post injection) and a late phase (23-25 h post injection). Infection was diagnosed when activity around the knee prosthesis increased by more than 10% compared with bone marrow. We found a sensitivity and a negative predictive value of 100%, a specificity of 80%, a positive predictive value of 81% and an accuracy of 89%. Specificity and accuracy are lower than in the evaluation of hip prostheses; however, in comparison to other scintigraphic modalities, scintigraphy with the antigranulocyte antibody BW 250/183 is superior in excluding infection and has better specificity and accuracy. Therefore, as in the case of hip prostheses, the described methodology appears to be the scintigraphic modality of choice for knee prostheses.
European journal of nuclear medicine and molecular imaging 12/2003; 30(11):1463-6. · 4.99 Impact Factor
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Clinical Nuclear Medicine 03/2003; 28(2):136-7. · 3.67 Impact Factor
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ABSTRACT: Dynamic renal scintigraphy (DRS) during controlled diuresis is the method of choice to diagnose the functional relevance
of urinary tract obstruction in children with sonographically demonstrated hydronephrosis. However, there are no commonly
accepted scintigraphic criteria for surgical intervention. On the basis of our findings, we propose four stages of washout
(WO) of tracer following diuresis: in stage I, WO>50%, neither further diagnosis nor intervention is necessary; in stage II,
50%≥WO≥12%, repetition of DRS is advised within 3–4 months; and in stage III, 12%>WO≥5%, DRS should be repeated within 1–2
months. Only in stage IV, WO<5%, should surgery be done immediately. This procedure reduces surgical interventions by 50%
without increasing the risk of residual renal damage.
European journal of nuclear medicine and molecular imaging 12/1998; 26(1):18-21. · 4.99 Impact Factor
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ABSTRACT: Tumor M2-PK (Tu M2-PK) as the inactive dimeric form of pyruvate kinase M2 has been proven to be elevated in breast, lung, renal and gastrointestinal malignancies. We compared this marker in 26 patients with metastatic thyroid carcinoma using the established tumor marker thyroglobulin (Tg).
Plasma Tu M2-PK was measured using an ELISA assay (Schebo Biotech, Giessen, Germany) and Tg was measured in serum using an electrochemiluminescence Immunoassay (Tg Elecsys Systems, Roche, Germany), as a part of the routine follow-up of the patients.
At a cut-off of 15 U/ml, Tu M2-PK was elevated in 50% of the patients; at a cut-off of 20 U/ml (grey zone 15-20 U/ml), Tu M2-PK was elevated in 27% of the patients. The correlation coefficient between serum Tg level and Tu M2-PK was -0.093.
Tu M2-PK is less valuable for the detection of malignant thyroid disease than Tg.
Anticancer research 23(6D):5237-40. · 1.73 Impact Factor
