Farah Peiravian

Publications (8)16.79 Total impact

• Article: Short-Term Result of Ductus Arteriosus Stent Implantation Compared With Surgically Created Shunts.

  Hamid Amoozgar, Sirous Cheriki, Mohammad Borzoee, Gholamhossein Ajami, Manouchehr Soltani, Maryam Ahmadipour, Farah Peiravian, Amirali Amirghofran
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  ABSTRACT: This report aims to compare the researchers' early experience with the safety, efficacy, short-term outcomes, and complications of patent ductus arteriosus (PDA) stents in neonates having duct-dependent pulmonary circulation with those of surgically created shunts. Between April 2009 and April 2011, 18 infants with duct-dependent pulmonary circulation underwent cardiac catheterization for PDA stenting as the first palliative procedure in a referral center. For comparison, 20 infants who underwent surgical aortopulmonary shunt placement in another center were used. Follow-up assessment included clinical examination, echocardiography, oxygen saturation, and cardiac catheterization studies. Access and stenting for the PDA were successful in 15 patients (83.3 %). The mean procedure time was 58.43 ± 41.25 min, and the mean fluoroscopy time was 18.81 ± 5.64 min. Three patients (20 %) in the stented group and 6 patients (30 %) in the surgical group died (P = 0.09). After a 6-month follow-up period, none of the patients had significant stent stenosis requiring reintervention. The oxygen saturation increase did not differ significantly between the two groups either immediately after the procedure or 6 months later (P > 0.5). The left pulmonary artery diameter, McGoon ratio, and Nakata index did not differ significantly between the two groups (P > 0.05), but the right pulmonary diameter was larger in the stented group (5.01 ± 0.45 vs 4.1 ± 0.49 mm; P = 0.0001). Stenting for the PDA is an appropriate alternative to surgical shunt creation in many patients with duct-dependent circulation. In our sample, the two groups did not differ significantly in terms of outcome or mortality.
  Pediatric Cardiology 03/2012; · 1.30 Impact Factor
• Article: Causes for hospitalization and death in Iranian patients with β-thalassemia major.

  Masood Bazrgar, Farah Peiravian, Fatemeh Abedpour, Mehran Karimi
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  ABSTRACT: There are limited studies that have focused on the causes for hospitalization as an indicator of morbidity in patients with β-thalassemia major (BTM). A cross-sectional study was conducted to determine the main causes for hospitalization and death in hospitalized BTM patients in a referral hospital in Shiraz, southern Iran. During a 5-year period, 555 BTM patients were admitted to the hospital, of which 390 (67.7%) were 10 to 20 years of age. The most frequent causes for hospitalization were splenectomy (23%), heart failure (22.6%), liver biopsy (22.2%), uncontrolled diabetes (10.9%), arrhythmia (7.2%), cholecystectomy (3.8%), hypoparathyroidism (2.1%), and sepsis (2%). Of the hospitalized patients, 65 (11%), with a mean age of 16.1 ± 4.2 years, died. The most common causes of death were cardiomyopathy (72.3%), infections (17%), malignancies (3.1%), and cerebrovascular accidents (3.1%). Survival of our patients was less than in developed countries and cardiac complications were the most common cause of mortality and morbidity in these patients. Regarding the key role of iron chelation in prevention of different complications in BTM, correction of iron chelation regimen should be well considered.
  Pediatric Hematology and Oncology 03/2011; 28(2):134-9. · 0.89 Impact Factor
• Article: Triple-cavity left ventricle with an abnormal mitral valve apparatus.

  Ahmad Ali Amirghofran, Farah Peiravian, Ashkan Karimi, Kamran Aghasadeghi, Hamid Amoozgar, Siroos Cheriki
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  ABSTRACT: The patient is a 17-year-old boy who was referred to our center with complaints of easy fatigability and exertional dyspnea. In echocardiography, the left ventricle was identified to be composed of a small functional cavity, and 2 sequestrated apical cavities that communicated with the functional cavity only through few stenotic orifices. The mitral valve apparatus was also abnormal: there was no definite papillary muscle, and chordae tendineae arose from the aberrant fibromuscular ridge that partitioned the left ventricular cavity. Imaging findings and management of this patient with a triple-cavity left ventricle are discussed.
  The Annals of thoracic surgery 08/2010; 90(2):e20-2. · 3.74 Impact Factor
• Article: Absent pulmonary valve, intact interventricular septum, rudimentary aortic non-coronary cusp and ascending aortic aneurysm in a single patient.

  Ashkan Karimi, Farah Peiravian, Ahmad Ali Amirghofran, Ariana Kariminejad
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  ABSTRACT: Absent pulmonary valve (APV) is a relatively rare congenital heart disease, and is mostly associated with tetralogy of Fallot phenotype or ventricular septal defect. APV with intact interventricular septum (IVS) is even less common with case reports or very small series in the literature. Congenital aortic regurgitation with a rudimentary non-coronary cusp is also by itself a rare congenital anomaly and to our knowledge this is the first report of the combination of APV, intact IVS, abnormal aortic valve and ascending aortic aneurysm. The clinical course, possible etiologies and management are discussed.
  Interactive cardiovascular and thoracic surgery 04/2010; 10(4):636-8.
• Article: A wandering stent in the ascending aorta.

  Ahmad Ali Amirghofran, Farah Peiravian, Mohammad Borzoee, Abbas Emaminia, Reza Mollazadeh
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  ABSTRACT: A 15-year-old girl underwent patch aortoplasty for repair of a long-segment coarctation of the aorta 7 years ago. Balloon angioplasty had been performed twice, 3 and 5 years after the aortoplasty, because of recurrent coarctation of the aorta. She was scheduled for balloon angioplasty and stent implantation. In catheterization, there was 55 mmHg gradient between ascending and descending aorta and the angiography showed long-segment coarctation of the aorta, from the transverse aorta, after the innominate artery, to the descending aorta, after the left subclavian artery. During the final pressure measurement, in the catheterization laboratory, the stent was dislodged proximally and trial for reimplantation or retrieval failed. Echocardiography showed the trapped stent in the ascending aorta. She was taken to the operating room, where the stent was removed and the aortic arch was reconstructed from the innominate artery to the distal part of the subclavian artery, using a Dacron patch.
  Journal of Cardiovascular Medicine 10/2008; 9(9):969-70. · 1.51 Impact Factor
• Article: Apolipoprotein E polymorphism in Southern Iran: E4 allele in the lowest reported amounts.

  Masood Bazrgar, Mehran Karimi, Mohsen Fathzadeh, Sara Senemar, Farah Peiravian, Ashraf Shojaee, Mostafa Saadat
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  ABSTRACT: Apolipoprotein E (apoE) with three major alleles E2, E3 and E4 is one of the critical genes in lipid metabolism. Common apoE alleles are in association with an increase in risk for central nervous and cardiovascular diseases such as Alzheimer's disease, dementia, multiple sclerosis, atherosclerosis, coronary heart disease, hyperlipoproteinemia and stroke. ApoE3 is known as the most frequent allele in all populations, while association of apoE gene polymorphism with reported diseases have mostly been related to other two major alleles especially apoE4. To determine of apoE alleles frequencies in Southern Iran and comparison of those frequencies with other populations. DNA was extracted from the whole blood of 198 healthy unrelated candidates from population of Fars Province, Southern Iran, for apoE genotyping who were checked up by a physician. The frequencies of apoE alleles were compared with other populations by chi(2) test. The frequencies of E2, E3 and E4 were 0.063, 0.886 and 0.051 respectively. These values were similar to those reported from populations of Kuwait, Oman, Lebanon, India, Turkey, Greece, Spain, Sardinia Islands of Italy and two Iranian populations but were different from South of Italy and Caucasians in other Europe regions, American, American-Indian, African, East Asian and Saudi populations (P < 0.05). The frequency of E4 allele as a genetic risk factor for some multifactorial diseases in the population of Southern Iran is in the lowest reported amounts in the world. Iranian population has Caucasoid origin but differs from some Caucasian populations in Europe and America. The results of present study are in agreement with the historical evidences which show admixture of Iranian population with other populations and some studies based on genetic polymorphisms in the population of Southern Iran.
  Molecular Biology Reports 06/2007; 35(4):495-9. · 2.93 Impact Factor
• Article: Oral sildenafil to control pulmonary hypertension after congenital heart surgery.

  Farah Peiravian, Ahmad A Amirghofran, Mohammad Borzouee, Gholam H Ajami, Mohammad R Sabri, Sara Kolaee
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  ABSTRACT: This study investigates the role of oral sildenafil in decreasing pulmonary pressure after congenital heart surgery. Between September 2002 and September 2004, among a group of postoperative children with large septal defects, moderate to severe pulmonary hypertension [pulmonary artery (PA) to aortic (Ao) pressure ratio of 0.76 +/- 0.17] and systemic desaturation (Ao Sat = 0.89 +/- 0.11), oral sildenafil (0.3 mg x kg(-1), every 3 hours) was administered for a period of 24-48 hours (sildenafil group). These patients were compared to a group of 22 children with similar pathologies who did not receive sildenafil (control group). Postoperative PA pressure (28.61 +/- 7.80 vs 39.40 +/- 10.80 mm Hg) and PA/Ao pressure (0.28 +/- 0.08 vs 0.41 +/- 0.11) were significantly lower in the sildenafil group ( p = 0.001 and 0.001 respectively). Pulmonary hypertensive crisis was detected in 4 patients in the control group, but none in the sildenafil group ( p = 0.02). There was no significant rise in PA pressure following discontinuation of the drug (26.30 +/- 6.66 vs 28.49 +/- 10.93 mm Hg, p = 0.366). No significant complications were noticed regarding sildenafil use. Low doses of oral sildenafil appear to be effective and safe to control postoperative PA pressure in children. Absence of rebound pulmonary hypertension, availability, and low cost of the drug are considered as its major advantages.
  Asian cardiovascular & thoracic annals 05/2007; 15(2):113-7.
• Article: Apolipoprotein E gene polymorphism and left ventricular function in Iranian patients with thalassemia major.

  Masood Bazrgar, Mehran Karimi, Farah Peiravian, Mohsen Fathzadeh
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  ABSTRACT: Left ventricular (LV) failure is the main cause of death in thalassemia. Iron overload in patients with thalassemia leads to the formation of oxygen free radicals. Of the various apolipoprotein E (apoE) alleles, apoE4 is the least efficient in conditions of oxidative stress in comparison with apoE2 and apoE3. Our results showed that apoE4 is a genetic risk factor for LV dysfunction in thalassemia.
  Haematologica 03/2007; 92(2):256-7. · 6.42 Impact Factor