Cong Luo,
Yongliang Zhu,
Tiejun Jiang,
Xiaoyong Lu,
Wo Zhang,
Qifeng Jing,
Jia Li,
Linrong Pang,
Kangjie Chen,
Fuming Qiu,
Xiuyan Yu, Jiahui Yang,
Jian Huang
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ABSTRACT: Matrine, one of the main active components from the dry roots of Sophora flavescence, was known to induce apoptosis in a variety of tumor cells in vitro. However, the molecular mechanism of cell apoptosis induced by Matrine remains elusive. Here, we investigated the apoptosis in Matrine-treated human gastric cancer MKN45 cells. The results showed that Matrine could inhibit cell proliferation and induce apoptosis in a dose-dependent manner. Further immunoblots revealed that in Matrine-treated cells, caspase-3, -7 were activated and the pro-apoptotic molecules Bok, Bak, Bax, Puma, and Bim were also up-regulated. Our results suggested that Matrine induced gastric cancer MKN45 cells apoptosis via increasing pro-apoptotic molecules of Bcl-2 family.
Toxicology 02/2007; 229(3):245-52. · 3.68 Impact Factor
