Taeyoung Choi

Catholic University of Daegu, Kayō, North Gyeongsang, South Korea

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Publications (4)6.59 Total impact

  • Taeyoung Choi, Eunsook Ma
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    ABSTRACT: A series of racemic indole C5-substituted seco-cyclopropylindoline compounds (2,3 and 5-7) were prepared by coupling 1-(tert-butyloxycarbonyl)-3-(chlorocarbonyl)indoline (seg-A) with 5,6,7-trimethoxy-, 5,6-dimethoxy-, 5-amino-, 5-methylsulfonylamino- and 5-(N,N-dimethylaminosulfonylamino) indole-2-carboxylic acid as seg-B in the presence of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide. The synthetic compounds (2,3 and 5-7) were tested for cytotoxic activity against human cancer cell lines (COLO 205, SK-MEL-2, A549, and JEG-3) using the MTT assay.
    Archives of Pharmacal Research 03/2011; 34(3):357-67. DOI:10.1007/s12272-011-0302-1 · 1.75 Impact Factor
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    Taeyoung Choi, Eunsook Ma
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    ABSTRACT: A series of racemic indole C5-O-substituted seco-cyclopropylindole (seco-CI) compounds 1-5 were prepared by coupling in the presence of EDCI of 1-(tert-butyloxycarbonyl)-3-(chloromethyl)indoline (seg-A) with 5-hydroxy-, 5-O-methylsulfonyl, 5-O-aminosulfonyl, 5-O-(N,N-dimethylaminosulfonyl)- and 5-O-benzyl-1H-indole-2-carboxylic acid as seg-B. Compounds 1-5 were tested for cytotoxic activity against four human cancer cell lines (COLO 205, SK-MEL-2, A549, and JEG-3) using a MTT assay. Compounds 2 and 3 with small sized sulfonyl substituents like 5-O-methylsulfonyl and 5-O-aminosulfonyl exhibit a similar level of activity as doxorubicin against all cell lines tested.
    Molecules 11/2010; 15(11):7971-84. DOI:10.3390/molecules15117971 · 2.42 Impact Factor
  • Eunsook Ma, Taeyoung Choi
    ChemInform 07/2009; 40(28). DOI:10.1002/chin.200928167
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    Taeyoung Choi, Eunsook Ma
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    ABSTRACT: Bromination of 5,6-dimethoxyindan-1-one with Br(2) in acetic acid at room temperature produced exclusively the corresponding 2,4-dibromo compound in 95% yield. Reaction of 5,6-dimethoxyindan-1-one with Br(2) in the presence of KOH, K(2)CO(3) or Cs(2)CO(3 )at ~0 degrees C( )gave the monobrominated product 4-bromo-5,6-dimethoxyindan-3-one in 79%, 81% and 67% yield, respectively. 5,6-Dihydroxyindan-1-one was dibrominated on the aromatic ring affording 4,7-dibromo-5,6-dihydroxyindan-1-one both in acetic acid at room temperature and in the presence of KOH at ~0 degrees C. 5,6-Difluoroindan-1-one and 1-indanone were alpha-monobrominated in acetic acid and alpha,alpha-dibrominated under KOH conditions at room temperature.
    Molecules 02/2007; 12(1):74-85. DOI:10.3390/12010074 · 2.42 Impact Factor

Publication Stats

2 Citations
6.59 Total Impact Points

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Institutions

  • 2007–2011
    • Catholic University of Daegu
      • College of Pharmacy
      Kayō, North Gyeongsang, South Korea