Akiko Harada

The University of Tokyo, Tōkyō, Japan

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Publications (4)12.89 Total impact

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    ABSTRACT: Insufficient levels of serum 25-hydroxyvitamin D [25(OH)D] lead to low bone mineral density (BMD) by increasing serum levels of intact parathyroid hormone (PTH), and are associated with a high mortality rate. Therefore, the 25(OH)D level is used as an indicator of frailty in older persons. To obtain higher serum 25(OH)D levels, management of lifestyle habits and nutrient intake is important beginning in a person's younger years. This study evaluated the degree of association between serum 25(OH)D concentrations and lifestyle factors in young Japanese women. A cohort study was conducted from December 2003, and the survey was finished by February 2004. The subjects were 274 Japanese women aged 19-25 years old. The parameters evaluated in these subjects included: (1) serum concentrations of 25(OH)D, intact PTH, calcium, and phosphorus; (2) BMD in the lumbar spine and hip; and (3) lifestyle factors (nutrient intake, physical activity, and duration of sunlight exposure). The serum 25(OH)D level was negatively associated with the intact PTH level (Spearman; r = -0.17, P = 0.006). The BMD was significantly higher in the high 25(OH)D and low intact PTH group than the other group (P < 0.05). The serum 25(OH)D level was significantly correlated with daily intake of dietary vitamin D (r = 0.20, P = 0.001), the mean number of steps taken per day (r = 0.16, P = 0.010) and the mean time spent in sedentary activity (r = -0.14, P = 0.018) among the lifestyle factors evaluated. Multiple regression analysis showed the degree of association between lifestyle factors and serum 25(OH)D to be small (R (2) = 0.084). Daily intake of dietary vitamin D and daily walking may be useful for increasing the serum 25(OH)D level in young Japanese women.
    Journal of Bone and Mineral Metabolism 05/2009; 27(6):682-8. DOI:10.1007/s00774-009-0095-1 · 2.46 Impact Factor
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    ABSTRACT: We explored factors that contributed to bone mineral density (BMD) in Japanese young women by quantifying the factors related to BMD. Between October 2003 and February 2004, we conducted a cross-sectional survey to study the status of nutritional intake and physical activity, and evaluated the various physical and serum parameters in relation to BMD. Subjects included 254 healthy female students who were 19-25 years old and were attending the Nursing School of Tokyo Women's Medical University, Japan. We measured the lumbar BMD (L2-L4) in these women. Multiple regression analysis was used to predict factors that contributed to current L2-L4 BMD. Our results showed that body mass index (BMI) (standardized regression coefficient = 0.45, P < 0.0001), past exercise habit (standardized regression coefficient = 0.15, P < 0.0059), and current total energy expenditure (standardized regression coefficient = 0.12, P < 0.03) were factors that significantly predicted the current L2-L4 BMD, with BMI as a key contributing factor. A BMI of 20.8 kg/m(2) allowed acquisition of young adult mean (YAM) irrespective of the total energy expenditure. In subjects with low BMI, L2-L4 BMD increased with higher current energy expenditure. A BMI of 20.8 kg/m(2) or greater and an energy expenditure of 32.9 METS-h/day or greater are required to acquire the YAM. We concluded that BMI and physical activity were factors that affected the BMD of Japanese young women.
    Journal of Bone and Mineral Metabolism 02/2007; 25(6):414-8. DOI:10.1007/s00774-007-0780-x · 2.46 Impact Factor

  • Medicine &amp Science in Sports &amp Exercise 05/2005; 37(Supplement):S178. DOI:10.1097/00005768-200505001-00929 · 3.98 Impact Factor

  • Medicine &amp Science in Sports &amp Exercise 05/2005; 37(Supplement). DOI:10.1249/00005768-200505001-00929 · 3.98 Impact Factor