Aaron Corona

Publications (2)0 Total impact

• Source

  Available from: Anne-Cécile Trillat

  Article: An extensive phenotypic characterization of the hTNFalpha transgenic mice.

  Michael D Hayward, Beverly K Jones, Arman Saparov, Heather S Hain, Anne-Cecile Trillat, Michelle M Bunzel, Aaron Corona, Bifang Li-Wang, Bryan Strenkowski, Caroline Giordano, Hai Shen, Emily Arcamone, Jeffrey Weidlick, Maria Vilensky, Marina Tugusheva, Roland H Felkner, William Campbell, Yu Rao, David S Grass, Olesia Buiakova
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  ABSTRACT: Tumor necrosis factor alpha (TNFalpha) is implicated in a wide variety of pathological and physiological processes, including chronic inflammatory conditions, coronary artery disease, diabetes, obesity, and cachexia. Transgenic mice expressing human TNFalpha (hTNFalpha) have previously been described as a model for progressive rheumatoid arthritis. In this report, we describe extensive characterization of an hTNFalpha transgenic mouse line. In addition to arthritis, these hTNFalpha transgenic mice demonstrated major alterations in body composition, metabolic rate, leptin levels, response to a high-fat diet, bone mineral density and content, impaired fertility and male sexual function. Many phenotypes displayed an earlier onset and a higher degree of severity in males, pointing towards a significant degree of sexual dimorphism in response to deregulated expression of TNFalpha. These results highlight the potential usefulness of this transgenic model as a resource for studying the progressive effects of constitutively expressed low levels of circulating TNFalpha, a condition mimicking that observed in a number of human pathological conditions.
  BMC Physiology 02/2007; 7:13.
• Article: An extensive phenotypic characterization of the hTNFα transgenic mice

  Michael Hayward, Beverly Jones, Arman Saparov, Heather Hain, Anne-Cecile Trillat, Michelle Bunzel, Aaron Corona, Bifang Li-Wang, Bryan Strenkowski, Caroline Giordano, Hai Shen, Emily Arcamone, Jeffrey Weidlick, Maria Vilensky, Marina Tugusheva, Roland Felkner, William Campbell, Yu Rao, David Grass, Olesia Buiakova
  [show abstract] [hide abstract]
  ABSTRACT: Abstract Background Tumor necrosis factor alpha (TNFα) is implicated in a wide variety of pathological and physiological processes, including chronic inflammatory conditions, coronary artery disease, diabetes, obesity, and cachexia. Transgenic mice expressing human TNFα (hTNFα) have previously been described as a model for progressive rheumatoid arthritis. In this report, we describe extensive characterization of an hTNFα transgenic mouse line. Results In addition to arthritis, these hTNFα transgenic mice demonstrated major alterations in body composition, metabolic rate, leptin levels, response to a high-fat diet, bone mineral density and content, impaired fertility and male sexual function. Many phenotypes displayed an earlier onset and a higher degree of severity in males, pointing towards a significant degree of sexual dimorphism in response to deregulated expression of TNFα. Conclusion These results highlight the potential usefulness of this transgenic model as a resource for studying the progressive effects of constitutively expressed low levels of circulating TNFα, a condition mimicking that observed in a number of human pathological conditions.
  BMC Physiology. 01/2007;