Roberto Bonmassari

Santa Chiara Hospital, Trient, Trentino-Alto Adige, Italy

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Publications (7)16.79 Total impact

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    ABSTRACT: BACKGROUND: -Atrial dilatation and atrial standstill are etiologically heterogeneous phenotypes with poorly defined nosology. In 1983 we described 8-years follow-up of idiopathic atrial dilatation with standstill evolution in 8 patients from 3 families. We later identified 5 additional patients with identical phenotypes: 1 member of the largest original family and 4 unrelated to the 3 original families. All families are from a same geographic area in the North-East Italy. METHODS AND RESULTS: -We followed-up the 13 patients for up to 37 years, extended the clinical investigation and monitoring to living relatives and investigated the genetic basis of the disease. The disease was characterized by: 1) clinical onset in adulthood; 2) bi-atrial dilatation up to giant size; 3) early supraventricular arrhythmias with progressive loss of atrial electrical activity to atrial standstill; 4) thromboembolic complications; 5) stable, normal left ventricular function and NYHA functional class during the long-term course of the disease. By linkage analysis we mapped a locus at 1p36.22 containing the natriuretic precursor A (NPPA) gene. By sequencing NPPA we identified a homozygous missense mutation (p.Arg150Gln) in all living affected individuals of the 6 families. All patients showed low serum levels of Atrial Natriuretic Peptide (ANP). Heterozygous mutation carriers were healthy and demonstrated normal levels of ANP. CONCLUSIONS: -Autosomal recessive Atrial Dilated Cardiomyopathy is a rare disease associated with homozygous mutation of the NPPA gene and characterized by extreme atrial dilatation with standstill evolution, thromboembolic risk, preserved left ventricular function and severely decreased levels of ANP.
    Circulation Cardiovascular Genetics 12/2012; · 6.73 Impact Factor
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    ABSTRACT: Cardiac lipomas are extremely rare neoplasms. We report the case of a 72-year-old woman with an incidental finding of a cardiac mass.
    Journal of Cardiovascular Medicine 12/2011; 12(12):885-6. · 2.66 Impact Factor
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    ABSTRACT: The aim of this study is to show the feasibility of a biventricular implantable cardioverter-defibrillator [cardiac resynchronization therapy (CRT)-ICD] implantation using an electroanatomic navigation system and a low dose of fluoroscopy. Here four case reports of patients affected by dilated cardiomyopathy, who underwent cardiac resynchronization therapy, are described. During 2010, four patients were admitted to our Cardiology Department for implantation of an CRT-ICD device in primary prevention. All had an ejection fraction of <35% and were in New York Heart Association class III despite optimal medical therapy. The implantations were performed using the EnSite NavX system. All the leads were positioned in the cardiac chambers utilizing the three-dimensional navigation system and only using X-ray to check that the leads had been positioned correctly. To our knowledge, these cases are the first use of an electroanatomic system for implantation of an CRT-ICD device and in all four cases the cannulation of the coronary sinus (CS) was performed only using the mapping system. Electroanatomic navigation made it possible to minimize X-ray exposure during the implantation of the CRT-ICD device; in addition, the mapping system was used to choose the optimum position of the CS catheter using as reference the maximum activation delay between the two ventricles. The NavX system shows great potential during the implantation of an CRT-ICD device. It seems to be feasible, safe, and extremely beneficial in terms of a reduction in X-ray exposure. Furthermore, there is benefit of more detailed information and accuracy during the CS lead placement.
    Europace 08/2011; 14(1):107-11. · 2.77 Impact Factor
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    ABSTRACT: Atrial fibrillation (AF) is a very common arrhythmia. Currently available tools to control arrhythmic recurrences (antiarrhythmic agents, catheter ablation) are not entirely satisfactory. Recently attention has been directed to upstream therapy, in order to alter the arrhythmia substrate; the most promising drugs seem to be those targeting the renin-angiotensin-aldsterone system. Several post-hoc analyses from large trials, in different clinical situations, confirmed the efficacy of angiotensin-converting enzyme-inhibitors and angiotensin II receptor blockers in primary prevention of AF. On the contrary prospective randomized, placebo-controlled, and double-blind studies showed negative results as for secondary prevention of AF. The GISSI-AF trial, the largest study (1442 patients) dealing with the use of angiotensin II receptor blockers in prevention of AF recurrences, has not demonstrated any difference between patients treated with valsartan (51.4% AF recurrences in a 12-month follow-up) vs. the placebo group (52.1%, p = NS). Therefore, available data do not support the use of these drugs in secondary prevention of AF.
    Giornale italiano di cardiologia (2006) 11/2010; 11(11):829-34.
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    ABSTRACT: We report the first case in the literature of acute myocardial infarction due to very late (5 years) drug-eluting stent (DES) thrombosis presenting with inferior ST-elevation myocardial infarction immediately after epileptic convulsive seizures in a patient with known coronary artery disease. A bare-metal stent had been implanted in the left anterior descending coronary artery in 2002, and a drug-eluting stent implanted in the right coronary artery in 2003. We discuss the possible pathogenetic mechanisms implied in convulsive epileptic crisis resulting in development of very late DES thrombosis.
    Journal of Thrombosis and Thrombolysis 09/2009; 29(4):512-5. · 1.99 Impact Factor
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    ABSTRACT: To evaluate the feasibility and accuracy of 16-slice spiral computed tomography (MSCT) in detecting coronary artery lesions in a low to moderate risk population. MSCT was performed in 33/78 patients at low to moderate risk for coronary artery disease affected by mitral and/or aortic valve disease and scheduled for conventional coronary angiography for pre-surgery evaluation. The sensitivity (SE), specificity (SP), positive (PPV) and negative predictive values (NPV) to identify >or=50% obstructed lesions were evaluated. Moreover, a discriminant predictive statistical analysis was performed. MSCT visualised 428/479 (89%) segments identified at coronary angiography and the percentage of evaluable segments was 87%. By including all coronary branches, SE, SP, PPV and NPV were 69%, 96%, 58% and 97%, respectively. By excluding the segments with a diameter of <or=2 mm, SE and SP were 74% and 96%, respectively (MSCT correctly identified 17/23 lesions). In the evaluable coronary arteries, SE and SP were 86% and 88% for the left anterior descending coronary artery, 100% and 85% for the left circumflex coronary artery, and 86% and 89% for the right coronary artery, respectively. SP was 100% for the left main artery. When restricting the analysis to the patients, 22/23 patients were adequately evaluable, and SE, SP, PPV and NPV were 100%, 80%, 85% and 100%, respectively. Using the discriminant predictive statistical analysis of quantitative (age, heart rate and calcium score) and qualitative variables (presence or absence of critical lesions at MSCT), an overall accuracy of 85% was obtained. The percentage of adequately evaluable patients was low because of limitations due to calcifications. In selected populations at low to moderate risk for coronary artery disease, MSCT has a high NPV in the evaluation of coronary artery stenosis.
    Journal of Cardiovascular Medicine 11/2006; 7(11):817-25. · 2.66 Impact Factor
  • Maurizio Centonze, Roberto Bonmassari, Luisa Manes
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    ABSTRACT: 1. Dissecazione del tratto prossimale dell’arteria circonflessa. 2. Possibile piccolo pseudo-aneurisma all’origine dell’arteria circonflessa, complicanza della dissecazione. 3. Tratto prossimale dell’arteria circonflessa. 4. L’esame coronarografico con posizionamento di uno stent.