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New England Journal of Medicine 10/2007; 357(10):1018-27. · 53.30 Impact Factor
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ABSTRACT: Mass antibiotic treatment and facial cleanliness are central to WHO's strategy for the elimination of blindness caused by trachoma. Recent studies have highlighted the heterogeneous response of communities to mass treatment and the complex relation between infection with Chlamydia trachomatis and clinical disease. It is important to be able to explain these findings to predict and maximise the effect of treatment on active trachoma disease and blindness in the community. Here we review the immunobiology of trachoma and provide a simple conceptual model of disease pathogenesis. We show how incorporating this model into a mathematical framework leads to an explanation of the observed community distribution of infection, bacterial load, and disease with age. The predictions of the model and empirical data show some differences that underscore the importance of individual heterogeneity in response to infection. The implications of disease transmission and pathogenesis for trachoma control programmes are discussed.
The Lancet Infectious Diseases 07/2007; 7(6):420-7. · 17.39 Impact Factor
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The Lancet 12/2006; 368(9550):1865-6. · 38.28 Impact Factor
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ABSTRACT: El presente documento aborda normas que proporcionan tratamiento y recomendaciones basados en tres niveles de medidas de control de infecciones de tuberculosis: administrativas, ambientales y personales; con el fin del control concebidas para reducir el riesgo de transmisión la tuberculosis en establecimientos de asistencia sanitaria en países en desarrollo. Se centra en la seguridad del personal de salud y en los medios para reducir el riesgo de transmisión de un paciente a otro. Esta reimpresión del documento fue realizada con el apoyo financiero del Proyecto Vigía “Enfrentando a las amenazas de las Enfermedades Emergentes y Reemergentes”.
