T V Rubalova

Novosibirsk Institute of Organic Chemistry, Novo-Nikolaevsk, Novosibirsk, Russia

Are you T V Rubalova?

Claim your profile

Publications (1)2.42 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Pinusolide (1), a known platelet-activating factor (PAF) receptor binding antagonist, was synthesized from lambertianic acid (2), a labdane-type diterpene readily accessible in multigram quantities from the Siberian pine tree. It was shown that 1 not only decreases the proliferation activity of tumor cells at relatively low concentrations but specifically induces apoptosis at 100 microM via the mitochondrial pathway in the Burkitt lymphoma cell line BJAB. Also, using primary lymphoblasts and leukemic cells from children with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), a significant DNA fragmentation in pinusolide-treated cells could be detected in an ex vivo apoptosis assay.
    Bioorganic & Medicinal Chemistry Letters 09/2006; 16(16):4228-32. DOI:10.1016/j.bmcl.2006.05.077 · 2.42 Impact Factor

Publication Stats

17 Citations
2.42 Total Impact Points


  • 2006
    • Novosibirsk Institute of Organic Chemistry
      Novo-Nikolaevsk, Novosibirsk, Russia