Akimasa Fukui

Kurume University, Куруме, Fukuoka, Japan

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Publications (7)6.27 Total impact

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    ABSTRACT: To evaluate the accuracy and usefulness of the intra-operative diagnosis of ovarian tumor in laparoscopic surgery. Retrospective cohort study (Canadian Task Force classification II-3). A tertiary care university hospital. We reviewed the case of 262 who underwent laparoscopic surgery under the diagnosis of benign ovarian tumor by intra-operative assessment between January 2005 and December 2011 at our institution. Intra-operative pathological assessment using frozen sections. The intra-operative diagnosis of ovarian malignancies showed sensitivity of 80%, specificity of 99.6% and positive predictive value of 80%. The diagnostic accuracy of malignancy was 99.2% in the intra-operative pathological diagnoses. Mucinous tumors diagnosed intra-operatively showed differing intra-operative and final pathological diagnosis results significantly more frequently compared to the other types of tumor. The intra-operative pathological assessment of benign ovarian tumors in laparoscopic surgery was reliable. However, clinicians should recognize that it is possible to make an incorrect diagnosis in some situations, and they should exercise caution accordingly.
    Journal of Minimally Invasive Gynecology 12/2013; · 1.61 Impact Factor
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    ABSTRACT: Persistent infection of human papillomavirus (HPV) types 16 and 18 causes cervical cancer. To better understand immune responses to the prophylactic vaccine, HPV 16/18 L1 virus-like particles (HPV-VLPs), we investigated B cell epitopes of HPV16 L1-derived peptides. Sera from mice immunized with HPV-16/18 L1 VLPs were analyzed for their IgG titers against 10 different HPV16 L1-derived peptides (20-mer) that contain human leukocyte antigen (HLA)-class I A-2, A-24 and class II DR. One 20-mer peptide at positions 300 to 319 was identified as a common B cell epitope in both Balb/c (H-2d) and C57BL/6 (H-2b) mice. Mapping analysis showed that the 10-amino-acid sequence at positions 304to 313 was an immunogenic portion. It is of note that the binding capability of this 10-mer peptide to the HLA-A2 and HLA-A24 molecules was confirmed by the HLA class I stabilization assay. In addition, one unique 20-mer was determined as a B cell epitope in each strain. These results might provide new information for better understanding of immune responses to HPV 16 L1.
    Virology Journal 09/2012; 9:199. · 2.09 Impact Factor
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    ABSTRACT: A 61-year old woman underwent total abdominal hysterectomy and pelvic lymph node dissection under the diagnosis of endometrial cancer. Although pelvic lymph nodes were positive for adenocarcinoma with psamomma bodies, no other lesion that was a primary lesion was verified. A postoperative study revealed the existence of para-aortic lymph node and supraclavicular lymph node metastases. Therefore, the endometrial biopsy specimen was reviewed. With the findings of p53 positivity by immunohistochemistry in the papillary part, the final histopathological diagnosis was changed to endometrial serous adenocarcinoma. Postoperative chemotherapy followed by radiotherapy for supraclavicular lymph node metastasis achieved complete response. This type of tumor must be considered in a differential diagnosis when metastatic papillary serous carcinoma is detected, but the primary site remains unknown.
    Journal of Gynecologic Oncology 03/2011; 22(1):53-6. · 1.73 Impact Factor
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    European Journal of Cancer - EUR J CANCER. 01/2011; 47.
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    ABSTRACT: A case of polypoid endocervical adenomyoma in the uterine cervix was encountered in a 56-year-old woman. A well-circumscribed polypoid tumour was observed protruding from the uterine cervix. Based on the findings of MR imaging, the patient was assumed to have an adenoma malignum in the uterine cervix. The tumour was composed of a mixture of endocervical type proliferating glands and fascicles of smooth muscle. No distinct nuclear anaplasia, architectural abnormality, or evidence of destructive stromal invasion was observed. In our case, the tumour was a well-circumscribed polypoid lesion, with no cytologic abnormality, thus suggesting polypoid endocervical adenomyoma. The result of ancillary diagnostic modalities should be interpreted with caution and combined with gross and light microscopic findings.
    Radiography. 01/2008;
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    ABSTRACT: To reduce chemotherapy induced gonadotoxicity, co-treatment with gonadotropin releasing hormone against analogue (GnRHa) was tested using rat model. Leuprorelin acetate (Leuplin) with or without cisplatin (CDDP) was given subcutaneously at a dose of 9.4 microg/ml to Wistar strain female rats. The total number of follicles was counted and the maturation of follicles was evaluated at the largest section of the ovary on the 5th and 10th day after administration. Leuplin led the ovary to a resting phase in which primordial follicle occupied 80% of all follicles in only 5 days after administration. The serum E2 level was also down by the 5th day and maintained a low level to the 10th day. In co-treatment with GnRHa and CDDP rats, the primordial follicle occupied 90% of all follicles and the total number of follicles was higher than in CDDP alone rats. This rat model verified that GnRHa co-treatment well minimized CDDP induced gonadotoxocity by desensitization of the ovary. These results were promising for the clinical application introducing GnRHa co-treatment as ovarian protection in cancer chemotherapy in young women.
    The Kurume Medical Journal 02/2007; 54(1-2):25-9.
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    ABSTRACT: The aim of this study was to investigate whether fertility preservation influences the clinical outcome in patients with malignant germ cell tumors of the ovary (MGCTO). A case study analysis was performed on patients with MGCTO treated at Kurume University Hospital between 1986 and 2004. Thirty-five patients were included in the study, 14 with immature teratoma, 11 with dysgerminoma, eight with endodermal sinus tumor, and two with mixed germ cell tumor. Twenty-three patients had International Federation of Gynecology and Obstetrics stage I (Ia, 11; Ib, 2; Ic, 10), one had stage II, seven had stage III, and four had stage IV disease. Five patients with stage III or IV disease received radical surgery. Thirty patients underwent conservative surgery. As the adjuvant treatment, 30 patients received chemotherapy, while five patients did not receive any chemotherapy. The overall survival rate was 97.1%. One patient died of the disease. She was 13 years old with a stage IV endodermal sinus tumor. Twelve have attempted conception, and eight have achieved at least one pregnancy (66.7%). Irrespective of the stage of the disease, conservative surgery and adjuvant chemotherapy for MGCTO can achieve a favorable outcome in terms of survival and fertility.
    Journal of Obstetrics and Gynaecology Research 09/2006; 32(4):416-21. · 0.84 Impact Factor