Yakup Gümüşalan

Publications (3)3.55 Total impact

• Article: Effect of atorvastatin and ezetimibe treatment on serum lipid profile and oxidative state in rats fed with a high-cholesterol diet.

  Alptekin Yasim, Davut Ozbag, Metin Kilinc, Harun Ciralik, Harun Toru, Yakup Gümüşalan
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  ABSTRACT: The effects of ezetimibe and atorvastatin on serum lipid profile and oxidant-antioxidant system were investigated in rats. Seventy-two Sprague-Dawley rats were assigned to 6 groups. Group 1 was fed with standard rat chow. Group 2 and the other 4 groups were fed with a high-cholesterol diet: 10 mg/kg/d atorvastatin to group 3; 1 mg/kg/d atorvastatin to group 4; 10 mg/kg/d atorvastatin and 1 mg/kg/d ezetimibe to group 5; and 1 mg/kg/d ezetimibe to group 6. After 3 months, serum total, low-density lipoprotein, high-density lipoprotein cholesterol, and triglyceride levels, and the activities of malondialdehyde, glutathione peroxidase, and superoxide dismutase were measured in the plasma. In addition, the left anterior descending and femoral arteries were examined histopathologically. Serum total, low-density lipoprotein cholesterol, and triglyceride levels decreased slightly in group 3. However, administration of 1 mg/kg/d atorvastatin or 1 mg/kg/d ezetimibe did not significantly change lipid parameters. Plasma malondialdehyde levels slightly increased in group 2 compared with controls and decreased compared with both the atorvastatin regimens. However, malondialdehyde levels increased with the addition of ezetimibe to atorvastatin. Only the administration of ezetimibe significantly elevated the levels of malondialdehyde. Glutathione peroxidase and superoxide dismutase levels were also found to be significantly reduced in the groups receiving ezetimibe when compared with atorvastatin groups. Atorvastatin has a beneficial effect on oxidative stress in rats fed with high-cholesterol diet. A combination of ezetimibe with atorvastatin diminishes the beneficial effects of atorvastatin. Conversely, the sole administration of ezetimibe increases oxidative stress.
  The American Journal of the Medical Sciences 03/2010; 339(5):448-52. · 1.39 Impact Factor
• Article: C2 intralaminar screw placement: a quantitative anatomical and morphometric evaluation.

  Mehmet Senoğlu, Davut Ozbağ, Yakup Gümüşalan
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  ABSTRACT: To investigate the feasibility of placing a screw in the C2 lamina and evaluate the reliability of the surface of the dorsal arch of C2 as a landmark for determining the optimal site of screw entry. 88 adult human C2 spines were used. Seven measurements were determined for screw entry points, trajectories, and lengths for placement of intralaminar screws. The average width of right C2 lamina (1/3 upper segment) was 2.6 mm (1.2 to 4.1 mm). The average width of left C2 lamina (1/3 upper segment) was 2.6 mm (1 to 4 mm). The average width of right C2 lamina (1/3 middle segment) was 4.9 mm (2.6 to 6.8 mm). The average width of left C2 lamina (1/3 middle segment) was 4.9 mm (2.3 to 7.6 mm). The average width of right C2 lamina (1/3 lower segment) was 5.7 mm (3.3 to 8.2 mm). The average width of left C2 lamina (1/3 lower segment) was 5.8 mm (2.2 to 9.6 mm). The width of the upper one-third of C2 lamina is not appropriate for the placement of intralaminar screws. On the other hand, the width of the middle and lower one-third of C2 lamina is more convenient for intralaminar screw delivery.
  Turkish neurosurgery 08/2009; 19(3):245-8. · 0.62 Impact Factor
• Article: The effect of posterior bridging of C-1 on craniovertebral junction surgery.

  Mehmet Senoglu, Yakup Gümüşalan, Kasim Zafer Yüksel, Murat Uzel, Mustafa Celik, Davut Ozbag
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  ABSTRACT: The groove for the vertebral artery (VA) may be bridged on C-1, forming a canal through which the artery passes. Because this variant may significantly affect the commonly performed C-1 posterior laminectomy, the authors studied the incidence and radiological appearance of this anatomical feature in surgical specimens. Anatomical measurements were performed using a Vernier caliper (accurate to 0.1 mm) on 166 dry C-1 vertebrae. In addition, a convenience sample of 172 cervical x-ray films was evaluated. Partial osseous bridging was detected in eight (4.8%), and a complete osseous bridge, forming the canalis arteriae vertebralis (canal for the VA), was seen unilaterally (eight on the left and two on the right) in 10 (6%) and bilaterally in eight (4.8%) of the dry vertebrae. On lateral radiography, a complete bone bridge was observed on nine (5.2%) and a partial bridge on 10 (5.8%) of the 172 studies. The discovery of a common variant may necessitate an immediate change in surgical management, and this anomaly could even increase the rate of surgery-related complications. The VA canal, present in the C-1 vertebra in approximately 5% of the specimens evaluated, was a variant that may be protective against VA injury. Knowledge of this variant may help the surgeon undertaking procedures in the C-1 region.
  Journal of Neurosurgery Spine 08/2006; 5(1):50-2. · 1.53 Impact Factor