Jing Wang

The Third People's Hospital, Shen-ch’üan-shih, Zhejiang Sheng, China

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Publications (801)1628.44 Total impact

  • Wei Tang, Jing Wang
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    ABSTRACT: A facile and efficient hydrothermal route was used to synthesize flower-like ZnO. The morphology and composition of ZnO were characterized by X-ray diffraction (XRD) and scanning electron microscope (SEM). The XRD results that pure ZnO were formed without any other impurity peaks. Uniformly distributed flower-like ZnO were clearly observed from the SEM images. A possible growth model was proposed to simulate the formation of flower-like ZnO. The fabricated ZnO sensors exhibited good response to toluene than to other interfering gases such as acetone, ammonia and benzene. On the perspective of bond dissociation energy discrepancy, the good selectivity of the ZnO sensor to toluene was explained in detail. A reasonable sensing mechanism of ZnO sensor to toluene was proposed in the aspect of charge transfer.
    Sensors and Actuators B Chemical 02/2015; 207. · 3.84 Impact Factor
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    ABSTRACT: To understand the association between the cytokine network and psoriasis, the present study cultured human keratinocytes (HaCaT cells) and investigated the effects of the phosphatidylinositol‑3‑kinase (PI3K) p55 regulatory subunit (p55PIK), and its N‑terminal 24 amino acids (N24) on the regulation of endotoxin (LPS)‑induced cytokine secretion. The results of the enzyme‑linked immunosorbent assay and reverse transcription quantitative polymerase chain reaction revealed an increased release of the inflammatory cytokines, tumor necrosis factor (TNF)‑α, interleukin (IL)‑6 and IL‑8 in the HaCaT cells following LPS stimulation. Transfection with the adenovirus (AD)‑N24‑green fluorescent protein (GFP) suppressed the release of these cytokines, whereas AD‑p55PIK‑GFP increased their release. Immunocytochemistry detected a low level of nuclear factor (NF)‑κB p65 staining in quiescent HaCaT cells, which was localized primarily in the cytoplasm. LPS stimulation induced the translocation of NF‑κB p65 protein into the nucleus and intense staining suggested increased expression. Transfection with AD‑N24‑GFP reduced the expression of NF‑κB p65 in the nucleus. Western blot analysis demonstrated that AD‑N24‑GFP downregulated the expression levels of the Toll‑like receptor (TLR)2/TLR4/myeloid differentiation factor 88 (MyD88) pathway components in the HaCaT cells, without affecting the PI3K/Akt signaling pathway. Transfection with AD‑p55PIK‑GFP resulted in an increased expression level of MyD88 protein and phosphorylated Akt. Co‑transfection with AD‑N24‑GFP and AD‑p55PIK‑GFP did not significantly alter the levels of phosphorylated extracellular‑signal‑regulated kinases 1/2, c‑Jun N‑terminal kinases or p38, indicating that AD‑N24‑GFP and AD‑p55PIK‑GFP did not affect the mitogen‑activated protein kinase signaling pathway. In conclusion, AD‑N24‑GFP effectively inhibited the LPS‑induced expression levels of TNF‑α, IL‑6 and IL‑8. The elevated expression of p55PIK synergized with LPS and promoted the release of inflammatory cytokines. AD‑N24‑GFP and AD‑p55PIK‑GFP affected LPS‑induced inflammatory cytokine release in the HaCaT cells through the TLRs/MyD88 signaling pathways.
    Molecular Medicine Reports 01/2015; · 1.48 Impact Factor
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    ABSTRACT: Five new flavonoid glucosides (3-4, 10-12) and a new phenolic derivative (5), together with eight known compounds including three flavonoid glucosides (6-8), three phenolic compounds (1-2, 9) and two megastigmane glucosides (13, 14) were isolated from the ethanol extract of the aerial part of Sedum aizoon L. Among them, compound 9, 13 and 14 were isolated and identified from this genus for the first time. The structures of compounds were elucidated on the basis of 1D and 2D NMR (HSQC, HMBC, COSY) spectra and the HR-ESI-MS data. These compounds were tested for their antibacterial efficacies against both Gram-positive and Gram-negative bacteria, compounds 1, 2, 3, 7 and 10 showed certain antibacterial activity, it showed more potency against Gram-positive than against Gram-negative bacteria. Compound 2 showed the most pronounced antibacterial effectiveness against Staphyloccocus aureus Rosenbach with MIC value of 7.8 μg · mL− 1. The in vitro anti-proliferative activities against HepG2, MCF-7 and A549 tumor cell lines were also evaluated. The result suggested compound 7 exhibited moderate cytotoxic activities with IC50 values of 46.30, 75.27 and 49.76 μmol/L, respectively.
    Fitoterapia 01/2015; · 2.23 Impact Factor
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    ABSTRACT: The manganese tangstenates (MnWO4) was explored for the first time for the oxide sensing electrode of the yttria-stabilized zirconia electrolyte (YSZ) based mixed-potential type sensor for detecting hydrogen at elevated temperatures. The MnWO4/YSZ/Pt sensor was found to have a good sensitivity to different concentrations of hydrogen from 80 ppm to 960 ppm in the background of 10% O2/N2 at 500 °C. The sensor also indicated excellent selectivity to several possible interferents such as CO, C3H6, C3H8 and NO2. The reproducibility and signal repeatability of the sensor and humidity influence were also studied.
    Sensors and Actuators B Chemical 01/2015; 206:176–180. · 3.84 Impact Factor
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    ABSTRACT: Reversible posterior leukoencephalopathy syndrome (RPLS) is a clinical syndrome based on changes in clinical imaging, and it has been reported to mainly occur in adults. However, it has been recently discovered that RPLS is also prevalent in infant patients, particularly in those using glucocorticoids, immunosuppressant medications and cytotoxic drugs. The current study presents a 5-year-old male with a previous diagnosis of systemic-onset juvenile idiopathic arthritis (SoJIA) and macrophage-activation syndrome who developed posterior reversible encephalopathy syndrome during treatment with glucocorticoids, disease-modifying antirheumatic drugs and biological agent (etanercept) therapy. After ~5 days of treatment, the patient made a complete clinical recovery; the magnetic resonance imaging reviewed 2 weeks later showed that the previous hyper-intensity signal had disappeared and the multiple lesions in the brain had been completely absorbed. The case report shows that, conforming to recent literature, SoJIA in infants should be considered a risk factor for developing RPLS. The clinical manifestations of the disease are multiple, but usually reversible, and the patients mostly have a good prognosis. Rapid diagnosis and treatment is essential as early treatment may prevent progression to irreversible brain damage. By increasing the awareness of RPLS, the patient care may improve and further insight may be gained.
    Biomedical reports. 01/2015; 3(1):55-58.
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    ABSTRACT: Objectives To assess the effects of CBT on electroencephalograms activity in patients with orthodontic pain.Methods We recruited 24 young (18-28 yrs), healthy individuals with matched baseline characteristics, including pain intensity, anxiety levels, personality traits, and life-quality scores. Participants were randomly assigned to either the CBT intervention group (n = 12) or the blank control group (n = 12). Multi-channel continuous electroencephalograms signals and visual analog scale (VAS) scores were recorded before and after initial archwire placement for one week. A 1-month follow-up was conducted, when participants’ daily VAS scores were recorded.ResultsThe overall EEG spectral power of the CBT group was lower than that of the control group, especially in the theta (4-7 Hz) and beta (14-30 Hz) bands during the treatment period. An enhanced coupling of theta and beta frequencies was observed in frontal and occipital electrodes respectively. The EEG power in delta and theta bands correlated positively with pain intensity. Network coherence for the CBT group exhibited higher connectivity in the theta band.Conclusions Specific cerebral responses to CBT instructions could be detected with continuous electroencephalograms and related to orthodontic pain processing, which may provide a new insight in exploring CBT for orthodontic pain control.This article is protected by copyright. All rights reserved.
    Oral Diseases 01/2015; · 2.40 Impact Factor
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    ABSTRACT: The external controllability of the magnetic properties in topological insulators would be important both for fundamental and practical interests. Here we predict the electric-field control of ferromagnetism in a thin film of insulating magnetic topological insulators. The decrease of band inversion by the application of electric fields results in a reduction of magnetic susceptibility, and hence in the modification of magnetism. Remarkably, the electric field could even induce the magnetic quantum phase transition from ferromagnetism to paramagnetism. We further propose a topological transistor device in which the dissipationless charge transport of chiral edge states is controlled by an electric field. In particular, the field-controlled ferromagnetism in magnetic topological insulator can be used for voltage based writing of magnetic random access memories in magnetic tunnel junctions. The simultaneous electrical control of magnetic order and chiral edge transport in such devices may lead to electronic and spintronic applications for topological insulators.
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    ABSTRACT: Cucumber, Cucumis sativus L., is an economically important vegetable crop which is processed or consumed fresh worldwide. However, the narrow genetic base in cucumber makes it difficult for constructing high-density genetic maps. The development of massively parallel genotyping methods and next-generation sequencing (NGS) technologies provides an excellent opportunity for developing single nucleotide polymorphisms (SNPs) for linkage map construction and QTL analysis of horticultural traits. Specific-length amplified fragment sequencing (SLAF-seq) is a recent marker development technology that allows large-scale SNP discovery and genotyping at a reasonable cost. In this study, we constructed a high-density SNP map for cucumber using SLAF-seq and detected fruit-related QTLs. An F2 population of 148 individuals was developed from an intra-varietal cross between CC3 and NC76. Genomic DNAs extracted from two parents and 148 F2 individuals were subjected to high-throughput sequencing and SLAF library construction. A total of 10.76 Gb raw data and 75,024,043 pair-end reads were generated to develop 52,684 high-quality SLAFs, out of which 5,044 were polymorphic. 4,817 SLAFs were encoded and grouped into different segregation patterns. A high-resolution genetic map containing 1,800 SNPs was constructed for cucumber spanning 890.79 cM. The average distance between adjacent markers was 0.50 cM. 183 scaffolds were anchored to the SNP-based genetic map covering 46% (168.9 Mb) of the cucumber genome (367 Mb). Nine QTLs for fruit length and weight were detected, a QTL designated fl3.2 explained 44.60% of the phenotypic variance. Alignment of the SNP markers to draft genome scaffolds revealed two mis-assembled scaffolds that were validated by fluorescence in situ hybridization (FISH). We report herein the development of evenly dispersed SNPs across cucumber genome, and for the first time an SNP-based saturated linkage map. This 1,800-locus map would likely facilitate genetic mapping of complex QTL loci controlling fruit yield, and the orientation of draft genome scaffolds.
    BMC genomics. 12/2014; 15(1):1158.
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    ABSTRACT: To investigate cellular immune function and its clinical significance in patients with multiple myeloma (MM). 45 MM patients were divided into three groups:newly diagnosed (n=18), stable stage (n=17) and relapsed/refractory (n=10). The frequencies of T cell subtypes, natural killer (NK) cells, dendritic cells (DC), helper T cells (including Th1 and Th2), regulatory T cells(Treg) and Th17 cells in peripheral blood were detected by flow cytometry. Serum concentrations of β2 microglobulin (β2-MG), lactate dehydrogenase (LDH) and hemoglobin (Hb) were also detected, respectively. Compared with controls and stable stage group, the ratios of CD4+/CD8+, DC1/DC2, and Th1/Th2, the numbers of Treg and NK cells were significantly lower in newly diagnosed group. However, the ratio of IL-17A/Treg was significantly higher in newly diagnosed group (P<0.05). Compared with stable stage group, the ratios of CD4+/CD8+, DC1/DC2 and Th1/Th2 were significantly lower, and the ratio of IL-17A/Treg was significantly higher in relapsed/refractory group (P<0.05). In higher ISS stages, the ratios of CD4+/CD8+ and Th1/Th2 were significantly lower and the ratio of IL-17A/Treg was significantly higher (P<0.05). There were negative correlations between the ratios of CD4+/CD8+, DC1/DC2, Th1/Th2 and the levels of β2-MG and LDH, respectively (P<0.05). The ratio of IL-17A/Treg was positively correlated with the levels of β2-MG and LDH (P<0.05). They were no correlated with the level of Hb (P>0.05). The abnormal ratios of CD4+/CD8+, DC1/DC2, Th1/Th2 and IL-17A/Treg were closely related with disease condition stages, treatment outcomes, progression and prognosis in MM patients.
    12/2014; 35(12):1053-7.
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    ABSTRACT: The data on the prognostic values of high sensitivity C-reactive protein (hsCRP) levels in patients with advanced symptomatic heart failure (HF) receiving cardiac resynchronization therapy (CRT) are scarce. The aim of present study was to investigate the association of serum hsCRP levels with left ventricle reverse remodeling after six months of CRT as well as long-term outcome. A total of 232 CRT patients were included. The assessment of hsCRP values, clinical status and echocardiographic data were performed at baseline and after six months of CRT. Long-term follow-up included all-cause mortality and hospitalizations for HF. During the mean follow-up periods of 31.3 ± 31.5 months, elevated hsCRP (> 3 mg/L) prior to CRT was associated with a significant 2.39-fold increase (P = 0.006) in the risk of death or HF hospitalizations. At 6-month follow-up, patients who responded to CRT showed significant reductions or maintained low in hsCRP levels (-0.5 ± 4.1 mg/L reduction) compared with non-responders (1.7 ± 6.1 mg/L increase, P = 0.018). Compared with patients in whom 6-month hsCRP levels were reduced or remained low, patients in whom 6-month hsCRP levels were increased or maintained high experienced a significantly higher risk of subsequent death or HF hospitalizations (Log-rank P < 0.001). The echocardiographic improvement was also better among patients in whom 6-month hsCRP levels were reduced or remained low compared to those in whom 6-month hsCRP levels were raised or maintained high. Our findings demonstrated that measurement of baseline and follow-up hsCRP levels may be useful as prognostic markers for timely potential risk stratification and subsequent appropriate treatment strategies in patients with advanced HF undergoing CRT.
    Journal of geriatric cardiology : JGC. 12/2014; 11(4):296-302.
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    ABSTRACT: Renal insufficiency (RI) is significantly associated with clinical prognosis in patients with heart failure (HF), but direct evidences on the relation between renal function and clinical outcome in patients receiving cardiac resynchronization therapy (CRT) are limited. The aim of the current study was to systematically evaluate the association of baseline and 6-month renal function with cardiac reverse remodeling and long-term outcome after CRT. We retrospectively evaluated 190 consecutive patients who underwent CRT at Fuwai Hospital from January 2008 to April 2013. Renal function tests, echocardiographic measurement, and clinical parameters at baseline and after 6 months of CRT were performed. Primary endpoint events included all-cause mortality, cardiac transplantation, and unplanned hospitalizations for HF. At baseline, compared with normal renal function or mild RI (estimated glomerular filtration rate (eGFR) ≥60 ml×min(-1)×1.73 m(-2)), moderate-to-severe RI (eGFR <60 ml×min(-1)×1.73 m(-2)) exerted a negative influence on cardiac reverse remodeling parameters. At 6-month follow-up, 114 (60.0%) patients were classified as responders and showed significant renal function improvement, whereas renal function deteriorated in non-responders and subsequently 41 (25.6%) patients developed worsening renal function (WRF). During the mean follow-up of (24.3±17.1) months, both patients with baseline eGFR <60 ml×min(-1)×1.73 m(-2) and those with WRF experienced worse event-free survival (P < 0.01, respectively). This analysis identified that baseline eGFR as well as WRF after CRT were found to be independent determinants of the combined endpoints of all-cause mortality and HF-related hospitalizations in CRT recipients.
    Chinese medical journal. 12/2014; 127(23):4036-42.
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    ABSTRACT: Aberrant activation of the Wnt/beta-catenin signaling pathway is an important factor in the development of nasopharyngeal carcinoma (NPC). Previous studies have demonstrated that the developmental gene sex-determining region Y (SRY)-box 1 (SOX1) inhibits cervical and liver tumorigenesis by interfering with the Wnt/-catenin signaling pathway. However, the role of SOX1 in NPC remains unclear. This study investigates the function of SOX1 in NPC pathogenesis. A quantitative methylation-specific polymerase chain reaction revealed that SOX1 was down-regulated and its promoter was hypermethylated in NPC cell lines and tissues. Ectopic expression of SOX1 in NPC cells suppressed colony formation, proliferation and migration in vitro and impaired tumor growth in nude mice. Restoration of SOX1 expression significantly reduced epithelial-mesenchymal transition, enhanced cell differentiation and induced cellular senescence. Conversely, transient knockdown of SOX1 by siRNA in these cells partially restored cell proliferation and colony formation. Notably, SOX1 was found to physically interact with beta-catenin and reduce its expression independent of proteasomal activity, leading to inhibition of Wnt/beta-catenin signaling and decreased expression of downstream target genes. SOX1 decreases the expression of beta-catenin in a proteasome-independent manner and reverses the malignant phenotype in NPC cells.
    Molecular Cancer 11/2014; 13(1):257. · 5.40 Impact Factor
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    ABSTRACT: Dental pulp/dentin regeneration using dental stem cells combined with odontogenic factors may offer great promise to treat and/or prevent premature tooth loss. Here, we investigate if BMP9 and Wnt/β-catenin act synergistically on odontogenic differentiation. Using the immortalized SCAPs (iSCAPs) isolated from mouse apical papilla tissue, we demonstrate that Wnt3A effectively induces early osteogenic marker alkaline phosphatase (ALP) in iSCAPs, which is reduced by β-catenin knockdown. While Wnt3A and BMP9 enhance each other's ability to induce ALP activity in iSCAPs, silencing β-catenin significantly diminishes BMP9-induced osteo/odontogenic differentiation. Furthermore, silencing β-catenin reduces BMP9-induced expression of osteocalcin and osteopontin and in vitro matrix mineralization of iSCAPs. In vivo stem cell implantation assay reveals that while BMP9-transduced iSCAPs induce robust ectopic bone formation, iSCAPs stimulated with both BMP9 and Wnt3A exhibit more mature and highly mineralized trabecular bone formation. However, knockdown of β-catenin in iSCAPs significantly diminishes BMP9 or BMP9/Wnt3A-induced ectopic bone formation in vivo. Thus, our results strongly suggest that β-catenin may play an important role in BMP9-induced osteo/ondontogenic signaling and that BMP9 and Wnt3A may act synergistically to induce osteo/odontoblastic differentiation of iSCAPs. It's conceivable that BMP9 and/or Wnt3A may be explored as efficacious biofactors for odontogenic regeneration and tooth engineering.
    Biomaterials 11/2014; · 8.31 Impact Factor
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    ABSTRACT: One of the greatest obstacles to current cancer treatment efforts is the development of drug resistance by tumors. Despite recent advances in diagnostic practices and surgical interventions, many neoplasms demonstrate poor response to adjuvant or neoadjuvant radiation and chemotherapy. As a result, the prognosis for many patients afflicted with these aggressive cancers remains bleak. The insulin-like growth factor (IGF) signaling axis has been show to play critical role in the development and progression of various tumors. Many basic science and translational studies have shown that IGF pathway modulators can have promising effects when used to treat various malignancies. There also exists a substantial body of recent evidence implicating IGF signaling dysregulation in the dwindling response of tumors to current standard-of-care therapy. By better understanding both the IGF-dependent and –independent mechanisms by which pathway members can influence drug sensitivity, we can eventually aim to use modulators of IGF signaling to augment the effects of current therapy. This review summarizes and synthesizes numerous recent investigations looking at the role of the IGF pathway in drug resistance. We offer a brief overview of IGF signaling and its general role in neoplasia, and then delve into detail about the many types of human cancer that have been shown to have IGF pathway involvement in resistance and/or sensitization to therapy. Ultimately, our hope is that such a compilation of evidence will compel investigators to carry out much-needed studies looking at combination treatment with IGF signaling modulators to overcome current therapy resistance.
    Genes & Diseases. 11/2014;
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    ABSTRACT: T-wave alternans (TWA) represents myocardial instability. The present study was to determine the impact of cardiac resynchronization therapy (CRT) on TWA and left ventricular ejection fraction (LVEF) in heart failure patients.
    Europace 11/2014; · 3.05 Impact Factor
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    ABSTRACT: RNA interference (RNAi) denotes sequence-specific mRNA degradation induced by short interfering double-stranded RNA (siRNA) and has become a revolutionary tool for functional annotation of mammalian genes, as well as for development of novel therapeutics. The practical applications of RNAi are usually achieved by expressing short hairpin RNAs (shRNAs) or siRNAs in cells. However, a major technical challenge is to simultaneously express multiple siRNAs to silence one or more genes. We previously developed pSOS system, in which siRNA duplexes are made from oligo templates driven by opposing U6 and H1 promoters. While effective, it is not equipped to express multiple siRNAs in a single vector. Gibson DNA Assembly (GDA) is an in vitro recombination system that has the capacity to assemble multiple overlapping DNA molecules in a single isothermal step. Here, we developed a GDA-based pSOK assembly system for constructing single vectors that express multiple siRNA sites. The assembly fragments were generated by PCR amplifications from the U6-H1 template vector pB2B. GDA assembly specificity was conferred by the overlapping unique siRNA sequences of insert fragments. To prove the technical feasibility, we constructed pSOK vectors that contain four siRNA sites and three siRNA sites targeting human and mouse β-catenin, respectively. The assembly reactions were efficient, and candidate clones were readily identified by PCR screening. Multiple β-catenin siRNAs effectively silenced endogenous β-catenin expression, inhibited Wnt3A-induced β-catenin/Tcf4 reporter activity and expression of Wnt/β-catenin downstream genes. Silencing β-catenin in mesenchymal stem cells inhibited Wnt3A-induced early osteogenic differentiation and significantly diminished synergistic osteogenic activity between BMP9 and Wnt3A in vitro and in vivo. These findings demonstrate that the GDA-based pSOK system has been proven simplistic, effective and versatile for simultaneous expression of multiple siRNAs. Thus, the reported pSOK system should be a valuable tool for gene function studies and development of novel therapeutics.
    PLoS ONE 11/2014; 9(11):e113064. · 3.53 Impact Factor
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    ABSTRACT: Although N-terminal pro-brain natriuretic peptide (NT-proBNP) is a useful screening test of impaired right ventricular (RV) function in conditions affecting the right-sided cardiac muscle, the role of NT-proBNP remains unclear in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). This study was designed to clarify the relation between the plasma NT-proBNP level and the RV function evaluated by cardiovascular magnetic resonance (CMR) imaging. We selected 56 patients with confirmed ARVC only when their blood specimens for NT-proBNP measurements were collected within 48 hours of a CMR scan. The NT-proBNP level was significantly higher in patients with RV dysfunction than in patients without RV dysfunction (median of 655.3 [interquartile range 556.4 to 870.0] vs 347.0 [interquartile range 308.0 to 456.2] pmol/L, p <0.001). The NT-proBNP levels were positively correlated with RV end-diastolic and end-systolic volume indices (r = 0.49 and 0.70, respectively) and negatively correlated with RV ejection fraction (r = -0.76, all p <0.001), which remained significant after adjustment for age, gender, and body mass index. The area under the receiver-operating characteristic curve for NT-proBNP was 0.91 (95% confidence interval 0.80 to 0.97, p <0.001). The cut-off value of NT-proBNP (458 pmol/L) was associated with sensitivity, specificity, and positive and negative predictive values of 91%, 89%, 67%, and 98%, respectively. In conclusion, NT-proBNP is a useful marker for the detection of RV dysfunction and associated with extent of RV dilatation and dysfunction determined by CMR in patients with ARVC. Copyright © 2014 Elsevier Inc. All rights reserved.
    The American Journal of Cardiology 11/2014; · 3.43 Impact Factor
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    ABSTRACT: Abstract The treatment outcome and development of new mutations in imatinib- and/or nilotinib-failure Ph+ leukemia patients with highly nilotinib-resistant mutations (Y253H, E255K/V and F359V/C) were assessed on dasatinib. A total of 111 Ph+ leukemia patients were grouped into 3 cohorts by baseline BCR-ABL kinase domain mutation status: no mutation (n=44), non-nilotinib-resistant mutations (n=26), or nilotinib-resistant mutations (n=41). The frequencies of hematological, cytogenetic and molecular responses and clinical resistance to dasatinib were similar among the 3 cohorts during dasatinib therapy. In dasatinib-resistant patients, new mutations were most frequently observed in the cohort with nilotinib-resistant mutations (P=0.001). Multivariate analyses revealed that the advanced disease and harboring the Y253H or F359V mutation before dasatinib were independent predictors of developing new mutations. We concluded that Ph+ leukemia patients with the Y253H or F359V mutation have a high likelihood of developing new mutations in the setting of dasatinib resistance.
    Leukemia and Lymphoma 11/2014; · 2.61 Impact Factor
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    ABSTRACT: Based on ab initio calculations, we predict that a monolayer of Cr-doped (Bi,Sb)2Te3 and GdI2 heterostructure is a quantum anomalous Hall insulator with a non-trivial band gap up to 38 meV. The principle behind our prediction is that the band inversion between two topologically trivial ferromagnetic insulators can result in a non-zero Chern number, which offers a better way to realize the quantum anomalous Hall state without random magnetic doping. In addition, a simple effective model is presented to describe the basic mechanism of spin polarized band inversion in this system. Moreover, we predict that 3D quantum anomalous Hall insulator could be realized in (Bi2/3Cr1/3)2Te3/GdI2 superlattice.
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    ABSTRACT: Several studies have showed the anti-cancer efficacy of 5-FU (5-fluorouracil) on pediatric tumors. Although the delayed demyelination induced by 5-FU in adult patients has been reported, the effect of 5-FU on oligodendrocyte myelination in adolescence is still unknown. Here, we demonstrate that systemic administration with 5-FU leads to immediate demyelination in the central nervous system (CNS) of adolescent mice, which is mainly attributed to the death of OLs. Gene-chip microarray transcriptome analysis identifies that oligodendrocyte-specific factor TCF7L2 may be a toxic target of 5-FU-impaired myelination. 5-FU-decreased TCF7L2 results in disruption of the interaction between TCF7L2 and HDAC1/2. Inhibition of crucial myelination-promoting factors by 5-FU is more significantly antagonized by co-transfection of TCF7L2, HDAC1 and HDAC2 than TCF7L2 alone. Our findings reveal that 5-FU could acutely induce the severe myelin degeneration in adolescence and disruption of TCF7L2/HDAC1/HDAC2 complex is at least partially involved in 5-FU-induced demyelination.
    Toxicology 11/2014; · 3.75 Impact Factor

Publication Stats

5k Citations
1,628.44 Total Impact Points


  • 2014
    • The Third People's Hospital
      Shen-ch’üan-shih, Zhejiang Sheng, China
    • Zhejiang University
      • College of Pharmaceutical Sciences
      Hang-hsien, Zhejiang Sheng, China
    • Chongqing Medical University
      Ch’ung-ch’ing-shih, Chongqing Shi, China
    • State Key Laboratory of Medical Genetics of China
      Ch’ang-sha-shih, Hunan, China
    • Soochow University (PRC)
      • Department of Materials Science and Engineering
      Wu-hsien, Jiangsu Sheng, China
  • 2012–2014
    • Beijing University of Chemical Technology
      Peping, Beijing, China
    • Stanford University
      • Department of Physics
      Palo Alto, California, United States
    • Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
      Shanghai, Shanghai Shi, China
    • Nanchang University
      Nan-ch’ang-shih, Jiangxi Sheng, China
    • Beijing Medical University
      • Department of Radiology
      Peping, Beijing, China
  • 2011–2014
    • Beijing Fuwai Hospital
      Peping, Beijing, China
    • Tongji University
      • College of Material Science and Engineering
      Shanghai, Shanghai Shi, China
    • Jilin University
      • College of Physics
      Jilin, Jilin Sheng, China
    • Paul Scherrer Institut
      Aargau, Switzerland
  • 2009–2014
    • Peking Union Medical College Hospital
      Peping, Beijing, China
    • Shanghai Jiao Tong University
      • Department of Electronic Engineering
      Shanghai, Shanghai Shi, China
    • École Polytechnique Fédérale de Lausanne
      • Polymers Laboratory
      Lausanne, Vaud, Switzerland
    • Renmin University of China
      Peping, Beijing, China
    • Wuhan Union Hospital
      Wu-han-shih, Hubei, China
  • 2008–2014
    • Dalian University of Technology
      • School of Chemical Engineering
      Lü-ta-shih, Liaoning, China
    • Samsung
      Sŏul, Seoul, South Korea
    • Chongqing University
      • School of Mechanical Engineering
      Chongqing, Chongqing Shi, China
    • Huawei Technologies Co. Ltd.
      Bao'an, Guangdong, China
  • 2007–2014
    • Sun Yat-Sen University Cancer Center
      Shengcheng, Guangdong, China
  • 2006–2014
    • Southeast University (China)
      • Department of Cardiology
      Nan-ching-hsü, Jiangxi Sheng, China
    • Peking University
      • • School of Public Health
      • • Academy for Advanced Interdisciplinary Studies
      • • Institute of Hematology
      • • Beijing National Laboratory for Molecular Science
      Peping, Beijing, China
    • Tongji Medical University
      • Department of Immunology
      Shanghai, Shanghai Shi, China
  • 2005–2014
    • Peking University People's Hospital
      Peping, Beijing, China
  • 2004–2014
    • Sun Yat-Sen University
      • • Department of Chemical Engineering
      • • State Key Laboratory of Oncology
      • • State Key Laboratory of Optoelectronic Materials and Technologies
      • • State Key Laboratory of Biocontrol
      Shengcheng, Guangdong, China
    • Chinese Academy of Sciences
      • • Institute of Psychology
      • • Key Laboratory of Rare Earth Chemistry and Physics
      Peping, Beijing, China
  • 2013
    • Ningbo University
      Ning-po, Zhejiang Sheng, China
    • Wannan Medical College
      Wu-hu-shih, Anhui Sheng, China
    • Hui Zhou University
      Kao-lan-hsien, Gansu Sheng, China
    • Jiangxi University of Traditional Chinese Medicine
      Nan-ch’ang-shih, Jiangxi Sheng, China
    • Hebei North University
      Chzhantseyakou, Hebei, China
    • University of Electronic Science and Technology of China
      Hua-yang, Sichuan, China
  • 2012–2013
    • Beijing University of Posts and Telecommunications
      • State Key Laboratory of Switching and Networking
      Peping, Beijing, China
    • Anhui Medical University
      • Institute of Dermatology
      Luchow, Anhui Sheng, China
  • 2011–2013
    • Northeast Institute of Geography and Agroecology
      • Institute of Psychology
      Peping, Beijing, China
  • 2009–2013
    • KTH Royal Institute of Technology
      • • School of Information and Communication Technology (ICT)
      • • Department of Microelectronics and Applied Physics (MAP)
      Tukholma, Stockholm, Sweden
    • Huazhong Agricultural University
      • College of Science
      Wu-han-shih, Hubei, China
    • Tongji Hospital
      Wu-han-shih, Hubei, China
  • 2008–2013
    • Peking University Third Hospital
      Peping, Beijing, China
  • 2007–2013
    • Huazhong University of Science and Technology
      • State Key Laboratory of Coal Combustion (SKLCC)
      Wu-han-shih, Hubei, China
    • Lanzhou University Second Hospital
      Kao-lan-hsien, Gansu Sheng, China
    • Shenyang Pharmaceutical University
      • • College of Pharmacy
      • • College of Traditional Chinese Medicine
      • • Department of Pharmacy
      Feng-t’ien, Liaoning, China
  • 2006–2013
    • Sichuan University
      • • Key Laboratory of Green Chemistry and Technology
      • • West China School of Stomatology
      • • Department of Orthodontics
      • • State Key Laboratory of Biotherapy
      Hua-yang, Sichuan, China
  • 1–2013
    • Tsinghua University
      • Department of Electronic Engineering
      Peping, Beijing, China
  • 2011–2012
    • Lanzhou University
      • School of Stomatology
      Lanzhou, Gansu Sheng, China
    • Capital Medical University
      • Department of Ophthalmology
      Peping, Beijing, China
  • 2009–2012
    • University of Texas MD Anderson Cancer Center
      • Department of Molecular and Cellular Oncology
      Houston, Texas, United States
  • 2008–2012
    • Liaoning Research Institute of Family Planning
      Feng-t’ien, Liaoning, China
    • Henan University
      • • Laboratory of Cellular and Molecular Immunology
      • • Institute of Immunology
      Kaifeng, Henan Sheng, China
  • 2006–2012
    • Nanjing University
      • • School of Medicine
      • • Department of Chemical Engineering
      Nanjing, Jiangsu Sheng, China
  • 2010–2011
    • Beijing FivePlus Molecular Medicine Institute
      Peping, Beijing, China
    • Dalian Ocean University
      Lü-ta-shih, Liaoning, China
    • Harbin Medical University
      Charbin, Heilongjiang Sheng, China
    • Tianjin Medical University Cancer Institute and Hospital
      T’ien-ching-shih, Tianjin Shi, China
    • University of Missouri - Kansas City
      • Division of Cell Biology and Biophysics
      Kansas City, Missouri, United States
    • Beijing University of Technology
      Peping, Beijing, China
  • 2008–2011
    • Beijing Genomics Institute
      Bao'an, Guangdong, China
  • 2008–2009
    • Nokia Siemens Networks
      Esbo, Southern Finland Province, Finland