Michel F P van der Jagt

Publications (4)8.82 Total impact

• Article: Metalloproteinases and their regulators in colorectal cancer.

  Michel F P van der Jagt, Theo Wobbes, Luc J A Strobbe, Fred C G J Sweep, Paul N Span
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  ABSTRACT: Metalloproteinases (MPs) such as the matrix metalloproteinases (MMPs) and adamalysins (ADAMs and ADAMTS) are expressed in various stages of colorectal cancer (CRC), and some correlate with survival and prognosis. The MPs are regulated by various factors including EMMPRIN, TIMPs, and RECK. In addition, micro-RNAs are found to be relevant for both MP expression levels and CRC prognostication. Both MPs and their regulators could be potential targets for intervention and therapy in CRC.
  Journal of Surgical Oncology 03/2010; 101(3):259-69. · 2.10 Impact Factor
• Article: Damage caused by a Kirschner wire.

  Tammo S de Vries Reilingh, Michel F P van der Jagt, William A H van der Stappen, Wout B Barendregt
  The Journal of trauma 12/2007; 63(5):1171-2. · 2.48 Impact Factor
• Article: Correlation of reversion-inducing cysteine-rich protein with kazal motifs (RECK) and extracellular matrix metalloproteinase inducer (EMMPRIN), with MMP-2, MMP-9, and survival in colorectal cancer.

  Michel F P van der Jagt, Fred C G J Sweep, Erwin T Waas, Thijs Hendriks, Theo J M Ruers, Audrey H H Merry, Theo Wobbes, Paul N Span
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  ABSTRACT: mRNA, and latent and active levels MMP-2 and -9 were higher in tumor tissue compared to normal tissue from 63 patients with colorectal cancer, whereas RECK and EMMPRIN levels were lower. Correlations between mRNA, latent, and active MMP were particular high for MMP-2 in tumor tissue (R(s)=0.6-0.8, P<0.001). For active MMP-2, but not for MMP-9, a significant negative partial correlation (R(p)=-0.440, P<0.001) for RECK was found in tumor tissue, which was confirmed by linear regression analysis. In exploratory survival analyses we found that in patients with localized disease the RECK level in normal or tumor tissue had a significant (P=0.017) association with overall survival.
  Cancer Letters 06/2006; 237(2):289-97. · 4.24 Impact Factor
• Article: Correlation of reversion-inducing cysteine-rich protein with kazal motifs (RECK) and extracellular matrix metalloproteinase inducer (EMMPRIN), with MMP-2, MMP-9, and survival in colorectal cancer

  Michel F.P. van der Jagt, Fred C.G.J. Sweep, Erwin T. Waas, Thijs Hendriks, Theo J.M. Ruers, Audrey H.H. Merry, Theo Wobbes, Paul N. Span
  [show abstract] [hide abstract]
  ABSTRACT: mRNA, and latent and active levels MMP-2 and -9 were higher in tumor tissue compared to normal tissue from 63 patients with colorectal cancer, whereas RECK and EMMPRIN levels were lower. Correlations between mRNA, latent, and active MMP were particular high for MMP-2 in tumor tissue (Rs=0.6–0.8, P<0.001). For active MMP-2, but not for MMP-9, a significant negative partial correlation (Rp=−0.440, P<0.001) for RECK was found in tumor tissue, which was confirmed by linear regression analysis. In exploratory survival analyses we found that in patients with localized disease the RECK level in normal or tumor tissue had a significant (P=0.017) association with overall survival.
  Cancer Letters.