Sylvie Camier

Pierre and Marie Curie University - Paris 6, Lutetia Parisorum, Île-de-France, France

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Publications (2)13.63 Total impact

  • Sylvie Camier, Bertrand Séraphin
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    ABSTRACT: Traditionally, mRNA decay was considered a simple destruction step of mRNA. This view has been challenged in the past years and mRNA decay now appears as an essential step in the regulation of gene expression. We first present a short review of the different reactions involved in mRNA decay, as well as some indications on their cellular location. Then, we describe two processes in which mRNA decay plays an essential role: (1) the mRNA quality control mechanisms that get rid of aberrant mRNAs (nonsensE-mediated decay, non-stop decay, no-go decay); (2) the regulation of mRNA stability through the targeting of specific factors to the mRNA (proteins or small non-coding RNAs).
    Medecine sciences: M/S 11/2007; 23(10):850-6. · 0.56 Impact Factor
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    ABSTRACT: mRNA decapping irreversibly targets mRNAs for fast decay. Cap removal is catalyzed by decapping protein Dcp2 but also requires Dcp1. Recently, two groups have provided a first glimpse of the regulation mechanism of this crucial step in gene expression. Resolution of the yeast Dcp2 structure has enabled identification of the residues that are important for its interaction with Dcp1. However, the human decapping machinery seems to be more complex because a third component, Hedls, is required for a functional Dcp1-Dcp2 interaction.
    Trends in Biochemical Sciences 06/2006; 31(5):241-3. · 13.08 Impact Factor

Publication Stats

18 Citations
13.63 Total Impact Points

Institutions

  • 2007
    • Pierre and Marie Curie University - Paris 6
      Lutetia Parisorum, Île-de-France, France