Jerzy Ratajczak

Instytut Hematologii i Transfuzjologii, Warszawa, Masovian Voivodeship, Poland

Are you Jerzy Ratajczak?

Claim your profile

Publications (6)4.52 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: The aim of the study is to present our own perioperative bridging therapy with low molecular weight heparin (LMWH) for surgical patients with thrombophilia on long-term acenokumarol therapy [oral anticoagulant (OAC)]. In some European countries, the drug used in secondary antithrombotic prophylaxis is acenokumarol. Forty-two patients with inherited thrombophilia and 21 with antiphospholipid syndrome underwent surgery. All patients were on long-term OAC. This OAC was interrupted 2 days before elective surgery and since that day half of the individual therapeutic dose of LMWH was administered. On day of surgery, the LMWH therapeutic dose was divided into two parts. Starting with day 2 after surgery, the patient was again given half of the individual dose of LMWH every 24 h. On day 4, OAC was additionally included. Both drugs were administered until stabilization of international normalized ratio (INR) values within the therapeutic target for 2 consecutive days. LMWH was then interrupted, whereas OAC continued. No symptoms or episodes of venous thromboembolism were observed. No intraoperative or postoperative hemorrhagic complications were reported. The results suggest that our perioperative bridging therapy is safe and effective for prevention of thromboembolic and hemorrhagic complications.
    Blood coagulation & fibrinolysis: an international journal in haemostasis and thrombosis 11/2010; 22(1):34-9. · 1.25 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The immediate effect of acute haemorrhage is a significant reduction in tissue blood flow, frequently resulting in haemorrhagic shock. The main aim of resuscitation after bleeding is the immediate restoration of intravascular volume. Intravenous administration of volume expanders should be commenced immediately, regardless of whether they are colloids or electrolytes. The purpose of the study was to analyze haemodynamic changes during intraoperative acute bleeding and to compare the effects of intravenous infusion with 7.5% saline solution to 6% starch solution on the volume resuscitation process. Sixty adult patients, of both sexes, in whom massive loss of blood followed by rapid cardiovascular collapse occurred during elective surgery, were enrolled in the study. In addition to standard fluid transfusion, all patients received either 4 mL kg(-1) of 7.5% NaCl solution or an equal volume of 6% of hydroxyethyl starch. Heart rate (HR) and mean arterial pressure (MAP) were noted. Cardiac output (CO) and systemic vascular resistance (SVR) were measured using a descending aortic blood flow ultrasound monitor. Massive intraoperative haemorrhage resulted in a rapid decrease in CO and SV with a simultaneous increase in HR and SVR in all patients. Injection of hypertonic salt or 6% HAES over 5 min increased the CO and SV. HR and SVR returned quickly to pre-existing levels and remained so until the end of the procedures. Small volume resuscitation with 7.5% saline or starch can be regarded as an efficient and effective method for restoring intravascular volume.
    Anestezjologia intensywna terapia 01/2009; 41(1):6-10. · 1.07 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Antimicrobial resistance due to the continuous selective pressure from widespread use of antimicrobials in humans, animals and agriculture has been a growing problem for last decades. KPC beta-lactamases hydrolyzed beta-lactams of all classes. Especially, carbapenem antibiotics are hydrolyzed more efficiency than other beta-lactam antibiotics. The KPC enzymes are found most often in Enterobacteriaceae. Recently, these enzymes have been found in isolates of Pseudomonas aeruginosa and Acinetobacter spp. The observations of blaKPC genes isolated from different species in other countries indicate that these genes from common but unknown ancestor may have been mobilized in these areas or that blaKPC-carrying bacteria may have been passively by many vectors. The emergence of carbapenem resistance in Gram-negative bacteria is worrisome because the carbapenem resistance often may be associated with resistance to many beta-lactam and non-beta-lactam antibiotics. Treatment of infections caused by KPC-producing bacteria is extremely difficult because of their multidrug resistance, which results in high mortality rates. Therapeutic options to treat infections caused by multiresistant Gram-negative bacteria producing KPC-carbapenemases could be used polymyxin B or tigecycline.
    Folia Histochemica et Cytobiologica 01/2009; 47(4):537-43. · 1.10 Impact Factor
  • Polish Journal of Surgery. 01/2009; 81(9):392-399.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The aim of this study was to evaluate the presence of aac(6')-Ib gene conferring resistance to aminoglycosides in Proteus mirabilis strains. Five isolates had aac(6')-Ib gene. In one case the gene was no-expressed. Three isolates were resistant to all aminoglycosides and minimum inhibitory concentrations were > or = 256 microg/ml. Additionally, all positive strains were resistant to tetracycline and ciprofloxacin.
    Folia Histochemica et Cytobiologica 01/2008; 46(4):531-3. · 1.10 Impact Factor
  • Adam Wiszniewski, Ksenia Bykowska, Jerzy Ratajczak
    [Show abstract] [Hide abstract]
    ABSTRACT: Background. Background. Background. Background. Background. Chronic venous ulceration (CVU), which is the end stage of the complex of symptoms of chronic venous disease (CVD), is a significant health problem. One of the major causes of CVU is deep venous thrombosis (DVT). Thrombophilia is diagnosed in about 41% of patients with a history of DVT. The aim of this study was to assess the prevalence of inherited thrombophilia (IT) in patients with CVU. Material and methods. Material and methods. Material and methods. Material and methods. Material and methods. During 24 months, a group of 110 patients with CVU and a group of 110 healthy people were studied. There were no significant differences in age or sex between the two groups. All patients in the study group were assessed as C5 or C6 according to CEAP classification. The patients underwent clinical and Doppler ultrasonography examination. Blood was drawn for antithrombin (AT), protein C (PC) and S (PS), factor V Leiden (VL), prothrombin G20210A (PT), LA, and ACL. Results. Results. Results. Results. Results. From the group of 110 CVU patients, IT was diagnosed in 33 (30%), LA in 5 (4.5%), and ACL in 12 (10.9%). Conclusions. Conclusions. Conclusions. Conclusions. Conclusions. Our results suggest that IT might be one of several important thrombotic risk factors which lead to CVU.