Qiu-Xu Wang

China Medical University (PRC), Shenyang, Liaoning, China

Are you Qiu-Xu Wang?

Claim your profile

Publications (11)0 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: To investigate the association between ERCC4 and ERCC5 polymorphisms and risk of salivary gland tumors. Case-control study was carried out in 133 cases of histologically confirmed salivary gland tumors and 142 age and gender matched healthy control cases. Polymorphisms of ERCC4 rs6498486 and ERCC5 rs751402 were detected by PCR-RFLP. Multiple factors logistic regression analysis was conducted to investigate the association between gene polymorphisms and risk of salivary gland tumors using SPSS 18.0 software package. The genotype distribution of each polymorphism was found to be of Hardy-Weinberg equilibrium in the study. ERCC5 rs751402 TT genotype was associated with risk of salivary gland tumors (TT vs. CC+CT: OR=0.45, 95% CI: 0.21-0.98, P=0.046). No significant association was found in ERCC4 rs6498486. The results suggest that ERCC5 rs751402 polymorphism may be associated with risk of salivary gland tumors.
    Shanghai kou qiang yi xue = Shanghai journal of stomatology 08/2013; 22(4):438-442.
  • [Show abstract] [Hide abstract]
    ABSTRACT: To study the expression and significance of pericytes and TGF-β in infantile parotid hemangioma. The expressions of pericytes and TGF-β at protein level were examined in 76 cases of infant parotid hemangioma by strep avidin-biotin complex (SABC) immunohistochemical technique. All statistical analysis were performed using SPSS 13.0 statistical package. The relationship between the expression of pericytes and TGF-β and clinical phase of hemangioma was analyzed by using Chi-square test. Kappa test was used to determine the relationship between pericytes and TGF-β expression. The rates of positive expression of pericytes were 86.7%(13/15), 45.5%(10/22) and 51.3%(20/39) in early, middle and advanced stage of hemangioma, respectively. The rates of positive expression of TGF-β were 33.3%(5/15), 40.9%(9/22) and 76.9%(30/39) in early, middle and advanced stage of hemangioma, respectively. There was significantly close correlation between the level of pericytes and clinical phase of hemangioma, as well as between TGF-β expression and clinical phase of hemangioma(P<0.05). Pericytes and TGF-β may significantly contribute to the proliferation of infantile parotid hemangioma.
    Shanghai kou qiang yi xue = Shanghai journal of stomatology 12/2012; 21(6):687-90.
  • [Show abstract] [Hide abstract]
    ABSTRACT: To reveal the relations between expression of extracellular signal-regulated kinase (ERK) and nm23-H1 and tumor invasion and metastasis in tongue squamous cell carcinoma (TSCC). The expression of ERK and nm23-H1 at protein level was examined in 74 cases of TSCC by strep avidin-biotin complex (SABC) immunohistochemical technique. SPSS10.0 software package was used for data analysis. The expression of ERK was positively related to TNM clinical stage and cervical lymph node metastasis. The expression of nm23-H1 was negatively related to TNM clinical stage and cervical lymph node metastasis. The expression of ERK had a negative correlation with the expression of nm23-H1. TSCC cases with ERK(+)/nm23-H1(-) revealed significant higher tendency to cervical lymph node metastasis than those with ERK(-)/nm23-H1(+). The expression of ERK and nm23-H1 is correlated with invasion and cervical lymph node metastasis in TSCC.
    Shanghai kou qiang yi xue = Shanghai journal of stomatology 06/2011; 20(3):269-72.
  • Wang Zhao, Qiu-xu Wang, Wei-xian Liu
    [Show abstract] [Hide abstract]
    ABSTRACT: To investigate the effect of platelet-rich plasma (PRP) and osteoinduction active material(OAM) compounded with PRP in the repair of bone defects of peri-implant and evaluate the feasibility of PRP as a material for repair of peri-implant bone defects. Four Beagle dogs underwent extraction of the mandibular first, second and fourth premolars to create edentulous regions. Three months later, titanium implants were inserted and bone defects around implants were created. The bone defects were repaired with PRP/OAM compounds in experimental group A, repaired with PRP/ tricalcium phosphate in experimental group B, and repaired with tricalcium phosphate in the control group. The animals were sacrificed at the end of 8-week and 16-week, respectively. The specimens were observed with histological examination and energy disperse analysis of Ca(2+). The data were analyzed with SPSS13.0 software package for one-way ANOVA. At 8-week, in experimental group A, some parts of implants were directly contacted with new bone. Some new bones formed in the experimental group B. There was fibrous connection between the bone and implant in the control group. At 16-week, there was mature Haversian system in the experimental group A. There was good osseointegration between the bone and implant in the experimental groups but only was fibrous connection in the control group. At 8-and 16-week, there was significant difference between there groups in the percentage of Ca(2+) (P<0.05). PRP and PRP/OAM composite can effectively accelerate the regeneration of peri-implant bone defects and improve the osseointegration in the interface between the implant and bone.
    Shanghai kou qiang yi xue = Shanghai journal of stomatology 07/2009; 18(3):307-12.
  • Wang Zhao, Qiu-Xu Wang, Wei-Xian Liu
    [Show abstract] [Hide abstract]
    ABSTRACT: To explore the potential of using osteoinduction active material (OAM) for reconstruction of bone defects of peri-implant by animal experiment, and provide experimental evidence for clinical application. Four Beagle dogs underwent extraction of the mandibular first and second premolar to create edentulous regions. 2 groups were divided randomly. Three months later, titanium implants were inserted and peri-implant bone defect models were established. The bone defects were repaired with OAM in the experimental group and repaired with tricalcium phosphate (TCP) in the control group. Two animals each were sacrificed at the end of 8 weeks and 16 weeks respectively. The specimens were evaluated with histological examination, scanning electric microscope, bone density examination, and energy disperse analysis of Ca(2+). The data was analyzed with SPSS13.0 software package for Student's t test. At 8-week,some parts of implants in the experimental group were directly contacted with new bone. There were fibers between the bone and implant in the control group. There was no significant difference between the experimental group and the control group in bone density (P>0.05). The percentage of Ca(2+) of the experimental group(22.16+/-3.33) was significantly greater than that of the control group(3.13+/-2.44) (P<0.05). At 16-week, there was good osseointegration between the bone and implant in the experimental group but no new bone formation in the control group. The bone density of the experimental group was significantly greater than that of the control group (P<0.05). The percentage of Ca(2+) of the experimental group(42.23+/-6.20) was significantly greater than that of the control group(10.40+/-3.12)(P<0.05). The results suggest that OAM can effectively accelerate the reconstruction of peri-implant bone defects and improve the osseointegration in the interface between the implant and bone.
    Shanghai kou qiang yi xue = Shanghai journal of stomatology 04/2009; 18(2):189-93.
  • [Show abstract] [Hide abstract]
    ABSTRACT: The aim of this study is to investigate the relationship between ERK1, ERK2 gene expression and tumor behavior such as invasion, metastasis in tongue squamous cell carcinoma (TSCC). The expressions of ERK1, ERK2 at gene level were examined in 45 cases of TSCC by reverse transcriptase polymerase chain reaction(RT-PCR). Student's t test was used for data analysis using SPSS 12.0 software package. No correlation between the expression intensity of ERK gene and tumor pathological degree of TSCC.A significant relationship was observed between the expression intensity of ERK gene and T stage of TSCC. A significant relationship was observed between the expression intensity of ERK gene and lymphnode metastasis of TSCC. Activation of ERK gene may play a strong role in cervical lymph node metastasis of TSCC. Intensive expression of ERK may be an important presage marker in TSCC patient. Supported by Key Science and Technology Research Project of Liaoning Province (Grant No.2005225013-2).
    Shanghai kou qiang yi xue = Shanghai journal of stomatology 11/2007; 16(5):458-60.
  • [Show abstract] [Hide abstract]
    ABSTRACT: To study the effects of implantation and implant connection on Beagle craniofacial bone growth. Eight Beagle dogs were randomly divided into two groups: unconnection group (4 dogs) and connection group (4 dogs). Two implant were implanted respectively in the lateral maxilla and zygomatic bone in each dog, the contra lateral side was used as normal control. Two implant was connected in the connection group 1 month later. Student's t test was used to analyze the data using SPSS11.5 software package. In the unconnection group, the distance increased between implants along with craniofacial bone growth; In the connection group, the distance fixed between implants along with craniofacial bone growth. The craniofacial values revealed no significant differences in the two groups (P > 0.05). The effect of implantation is localized and no inhibition in development of craniofacial bone is noted.
    Shanghai kou qiang yi xue = Shanghai journal of stomatology 10/2006; 15(5):547-50.
  • [Show abstract] [Hide abstract]
    ABSTRACT: To study the expressions and clinical significance of PTEN protein in tongue squamous cell carcinoma (TSCC). The expressions of PTEN at protein level was investigated in 74 cases of TSCC and 15 cases of normal peripheral tissues around cancer (as control) by strep avidin-biotin complex (SABC) immunohistochemical technique. Mann-Whitney U-test, Pearson's Chi-square test and Fisher exact test were used to analyze the data. The rates of the positive expression in normal tissue and TSCC of PTEN were 100% and 66.2% respectively (P<0.05). Pathological grade and T stage were not significantly related with the level of PTEN expression (P>0.05). There was significant correlation between the level of PTEN expression and cervical lymph node status (P<0.05). Expressions of PTEN is correlated with cervical lymphnode metastasis in tongue squamous cell carcinoma.
    Shanghai kou qiang yi xue = Shanghai journal of stomatology 05/2006; 15(2):133-5.
  • [Show abstract] [Hide abstract]
    ABSTRACT: To explore the effects of mandibular implant junction on the growth of immature bone. Eight Beagle dogs were randomly divided into three groups: control, unjunction and junction. Twelve implants were produced on the mandible of unjunction experimental group and junction experimental group. At three months after implanting, radiographic examination was performed. Three months after implanting, all implants were integrated with bone. None implants was mobile or got off. Radiographic examination demonstrated that the bone lose difference was no significant in junction and unjunction group. Mandibular implant connection wasn't effect on the growth of bone.
    Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 05/2006; 24(2):173-5.
  • [Show abstract] [Hide abstract]
    ABSTRACT: To study the expressions and clinical significance of urokinase-type plasminogen activator (uPA) and uPA receptor (uPAR) in tongue squamous cell carcinoma (TSCC). The expressions of uPA and uPAR at protein level were examined in 74 cases of TSCC and 15 cases of normal peripheral tissues around cancer (as control) by strep avidin-biotin complex (SABC) immunohistochemical technique. The relationship between the expressions of uPA and uPAR was evaluated by the Spearman's rank correlation test. Mann-Whitney U-test was used to examine the association of these factors with conventional clinical pathological factors. Pearson's Chi-square test was used to analyze the relationship between uPA, uPAR and cervical lymph node status. The rates of the positive expression in TSCC of uPA and uPAR were 71.6% and 64.8% respectively, and a positive relationship between expression of uPA and uPAR was found (P<0.05). There was significant correlation between the level of uPA expression and TNM stage or cervical lymph node status, either between the level of uPAR expression and cervical lymph node status. Pathological grade was not significantly related to the level of uPA expression. Pathological grade and TNM stage were not significantly related to the level of uPAR expression. TSCC cases with concurrent positive expression of these proteins revealed significant higher tendency of cervical lymph node metastasis than those with concourse negative expression (P<0.05). The expression of uPA and uPAR increased in TSCC, and uPA, uPAR may contribute significantly to TSCC invasion and metastasis.
    Shanghai kou qiang yi xue = Shanghai journal of stomatology 03/2006; 15(1):85-7.
  • Qiu-Xu Wang, Lei Shen, Chang-Fu Sun
    [Show abstract] [Hide abstract]
    ABSTRACT: To study the relationship between the expression of extracellular signal-regulated protein kinase (ERK) and the differentiation degree and lymphnode metastasis in oral squamous cell carcinoma. Immunohistochemical staining was used in 41 cases of OSCC to investigate the expression of ERK protein. Student's t test were used for statistical analysis. A significant relationship was observed between the expression intensity of ERK protein and clinicopathological features of OSCC (P<0.01). A significant relationship was observed between the expression intensity of ERK protein and lymph node metastasis of OSCC(P<0.05). No correlation between the expression intensity of ERK protein and cell differentiation degree of OSCC (P>0.05) was found. Activation of ERK may play a strong role in the development of OSCC. Intensive expression of ERK protein may be an important presage marker in OSCC patients.
    Shanghai kou qiang yi xue = Shanghai journal of stomatology 03/2005; 14(1):18-20.