Marcelo M Abrantes

Publications (3)6.05 Total impact

• Article: Predictive factors of chronic kidney disease in primary focal segmental glomerulosclerosis.

  Marcelo M Abrantes, Luis Sergio B Cardoso, Eleonora M Lima, José M Penido Silva, José S Diniz, Eduardo A Bambirra, Eduardo A Oliveira
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  ABSTRACT: Renal histological features of focal segmental glomerulosclerosis (FSGS) are found in 75% of pediatric patients with steroid-resistant nephrotic syndrome. In order to evaluate the predictive factors of chronic kidney disease (CKD), we retrospectively reviewed the records of 110 children with biopsy-proven FSGS admitted between 1972 and 2004. Renal survival was analyzed by the Kaplan-Meier method and Cox's regression model. Two multivariate models were developed: (1) from the onset of symptoms to the occurrence of CKD and (2) from the time of renal biopsy to CKD. Mean follow-up time was 10 years [standard deviation ((SD) 5.5], and 24 patients (21.8%) progressed to CKD. At baseline, after adjustment three variables remained as independent predictors of CKD: age >6.5 years (RR=3.3, 95% CI=1.3-7.8), creatinine >1 mg/dl (RR=2.5, 95% CI=0.97-6.5), and non-response to steroids (RR=7.3, 95% CI=2.7-19.7). In a model with continuous variables only age and non-response to steroids were associated with CKD. At the time of renal biopsy, after adjustment two variables remained as independent predictors of CKD: hematuria (RR=3.0, 95% CI=1.2-7.3) and creatinine >0.8 mg/dl (RR=4.3, 95% CI=1.7-10.6). In a model with continuous variables four factors predicted CKD: age, creatinine, hematuria, and percentage of global sclerosis.
  Pediatric Nephrology 07/2006; 21(7):1003-12. · 2.52 Impact Factor
• Article: Clinical course of 110 children and adolescents with primary focal segmental glomerulosclerosis.

  Marcelo M Abrantes, Luis Sergio B Cardoso, Eleonora M Lima, Jose Maria P Silva, Jose S Diniz, Eduardo A Bambirra, Eduardo A Oliveira
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  ABSTRACT: The purpose of this retrospective cohort study was to report the clinical course of children and adolescents with primary focal segmental glomerulosclerosis (FSGS). The records of 110 patients with biopsy-proven FSGS admitted between 1972 and 2004 were retrospectively reviewed. Demographic, clinical and laboratory data were recorded and histopathological data were reanalyzed by one pathologist who had no information about the outcome of the patients. Renal survival analysis was performed using the Kaplan-Meier method. Differences between subgroups (response to corticosteroids) were assessed by the two-sided log rank test. The median age at admission was 5 years (range: 1-15 years). Forty-two patients (38.2%) presented with hematuria at admission, and 55 (50%) presented blood pressure levels above the 95th percentile. Mean follow-up time was 10 years (SD 5.5). Twenty-four patients (21.8%) presented chronic kidney disease (CKD). It was estimated that the probability of CKD was 8% at 5 years, 17% at 10 years, and 32% at 15 years after diagnosis of nephrotic syndrome. In conclusion, on the basis of the clinical and histological characteristics observed, apparently our cohort of idiopathic FSGS is comparable with other published series. However, the long-term overall renal survival seems to be better in our cohort.
  Pediatric Nephrology 05/2006; 21(4):482-9. · 2.52 Impact Factor
• Article: [Overweight and obesity prevalence among children and adolescents from Northeast and Southeast regions of Brazil].

  Marcelo M Abrantes, Joel A Lamounier, Enrico A Colosimo
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  ABSTRACT: To study the prevalence of obesity and overweight among children and adolescents from Northeast and Southeast regions of Brazil. Data was collected form Life Pattern Research conducted by the Brazilian Institute of Geography and Statistics (IBGE) in 1997. A sample of 3,317 children and 3,943 adolescents was studied according age groups. Overweight (adolescents) and obesity (adolescents and children) were defined according to World Health Organization recommendations. Z-test was used to compare prevalence among age groups, sex and geographic region. The cut-off point for statistical significance was 0.05. Overweight prevalence in adolescents was 1.7% in Northeast and 4.2% in Southeast. Obesity prevalence in adolescents was 6.6% and 8.4% in children and 8.2% and 11.9% in Northeast and Southeast, respectively. Considering both regions prevalence of obese female children was 10.3%, the rate of obese adolescents was 9.3% and overweight adolescents represented 3.0%. Among males prevalence was 9.2%, 7.3% and 2.6%, respectively. Obesity prevalence is lower in Northeast than Southeast among children with age from 2 to 17 years old. Overweight prevalence among adolescents was also lower in Northeast than in Southeast. The prevalence of obesity among younger than 2 and older than 18 years old was the same. Obesity prevalence is higher among breast-fed females. Among other age groups prevalence of obesity and overweight was the same for males and females. It is difficult to compare these results with other studies, since there are few populational studies and the criteria used to define overweight and obesity in children and adolescents varies in each study.
  Jornal de Pediatria 78(4):335-40. · 1.01 Impact Factor