Eiko Inoue

Kyushu University, Hukuoka, Fukuoka, Japan

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Publications (1)8.31 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: To design a "mechano-active" small-diameter artificial vascular graft, a tubular scaffold made of elastomeric poly(L-lactide-co-epsilon-caprolactone) fabrics at different wall thicknesses was fabricated using an electrospinning (ELSP) technique. The wall thickness of the fabricated tube (inner diameter; approximately 2.3-2.5 mm and wall thickness; 50-340 microm) increased proportionally with ELSP time. The wall thickness dependence of mechanical responses including intraluminal pressure-induced inflation was determined under static and dynamic flow conditions. From the compliance-related parameters (stiffness parameter and diameter compliance) measured under static condition, the smaller the wall thickness, the more compliant the tube. Under dynamic flow condition (1 Hz, maximal/minimal pressure of 90 mmHg/45 mmHg) produced by a custom-designed arterial circulatory system, strain, defined as the relative increase in diameter per pulse, increased with the decrease in wall thickness, which approached that of a native artery. Thus, a mechano-active scaffold that pulsates synchronously by responding to pulsatile flow was prepared using elastomeric PLCL as a base material and an ELSP technique.
    Biomaterials 04/2006; 27(8):1470-8. DOI:10.1016/j.biomaterials.2005.08.029 · 8.31 Impact Factor

Publication Stats

74 Citations
8.31 Total Impact Points

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Institutions

  • 2006
    • Kyushu University
      • Graduate School of Medical Sciences
      Hukuoka, Fukuoka, Japan