Hai-xing Xu

Wuhan University of Technology, Wu-han-shih, Hubei, China

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Publications (6)5.89 Total impact

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    ABSTRACT: In this work, an amphiphilic polymeric prodrug Cis-3-(9H-purin-6-ylthio)-acrylic acid-graft-carboxymethyl chitosan (PTA-g-CMCS) was designed and synthesized. In aqueous solution, this grafted polymer can self-assemble into spherical micelles with a size ranging from 104 to 285 nm and zeta potential ranging from -12.3 to -20.1 mV. For the release study, less than 24% of 6-Mercaptopurine (6-MP) was released from PTA-g-CMCS1 in the media containing 2 and 100 μM glutathione (GSH), whereas 37%, 54% and 75% of 6-MP was released from the media with GSH of 1, 2 and 10mM, respectively. Besides, pH and drug content of the polymeric prodrug only presented slight influence on the 6-MP release. MTT assay demonstrated that this system had higher inhibition ratio on HL-60 cells (human promyelocytic leukemia cells) in the presence of GSH and lower cytotoxicity on mouse fibroblast cell line (L929). Therefore, this nano-sized system is glutathione-dependent, and it can be employed as a potential carrier for the controlled release of 6-MP.
    International Journal of Pharmaceutics 06/2012; 436(1-2):240-7. · 3.99 Impact Factor
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    ABSTRACT: To provide a FT-IR new method to identify different habitats of Solanum lyratum. Analyzed FT-IR patterns of Solanum lyratum from different habitats, and the similarity of different fingerprint patterns was calculated and analyzed according to the wave numbers of peaks searched. Obtained the different FT-IR pattern of 5 different habitats of Solanum lyraturn. This method can be used for identifications on different habitats of Solanum lyratum. The results of similarity calculation further prove the feasibility of this method.
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 06/2012; 35(6):896-8.
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    ABSTRACT: To provide an X-ray diffraction (XRD) method for identifying different medicinal parts of Solanum lyratum. Analyzed X-ray diffraction Fourier patterns of different parts of Solanum lyratum, and the similarity degree of different fingerprint was calculated and analyzed according to the position (2 theta value)of peaks searched. Different X-ray diffraction Fourier patterns of different medicinal parts of Solanum lyratum were obtained. This method can be used for identifying different medicinal parts of Solanum lyratum. The results of similarity calculation further proves the feasibility of this method.
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 01/2012; 35(1):42-4.
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    ABSTRACT: A rapid, sensitive, and simple high-performance liquid chromatographic (HPLC) method with an ultraviolet detector (UV) has been developed for the determination of oxaliplatin in the plasma of rabbits and tissues of mice. The sample preparation was carried out by complexation with 0.5 mL of DETC (diethyl-dithiocarbamate) solution and extracted by ether and chloroform. Then, 20 microL of supernatant was injected into the HPLC system with 0.25 mol/L of sodium chloride solution and methanol (30:70 v/v) as the mobile phase at a flow rate of 1.0 mL/min. Separation was performed with a C(18) column at 25 degrees C. The peak was detected at 254 nm. The calibration curve was linear (R(2) > or = 0.9995) in the concentration range of 0.1 approximately 200 microg/mL in plasma and tissues. The intra- and interday variation coefficients were not more than 2.61 and 3.83%, respectively. The limit of detection was 20 ng/mL. The mean recoveries of oxaliplatin were ranged from 97.83 to 104.17% in plasma and tissues. The present method has been successfully applied to the pharmacokinetic study of oxaliplatin liposome in mice and rabbits.
    Journal of Liposome Research 01/2009; 19(4):278-86. · 1.91 Impact Factor
  • Hai-xing Xu, Xiao-ping Liu, Yun-xia Gong
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    ABSTRACT: To extract volatile oil from Shiquandabu pills and study technological process of its inclusion compound with beta-Cyclodextrin (beta-CD) to improve its stability. The study was carried out with steam distillation and orthogonal design. The process conditions were studied by determining the utilization and ratio of oil from Shiquandabu pills volatile oil and extract ratio of in-clusion compound. The most important factor was the ratio of oil to beta-CD. and the inclusion compound was identified by FT-IR spectra and XRD. The optimum preparation conditions for inclusion were best-established as oil: beta-CD was 1:8, the inclusion time and temperature were for 1.0 hours. at 20 degrees C. Tne method can be used for increasing volatile oil's stability and its solubility. It is suitable for production of medicinal preparation.
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 08/2007; 30(7):861-2.
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    ABSTRACT: To set up a new identification and analysis method of Spora Lygodii. To get the extracts of Spora Lygodii using methanol, chloroform and petroleum ether as solvent and the extracts were identified, analyzed by X-ray diffraction Fourier fingerprint spectra. Experiments and analysis were carried out on three samples. The standard X-ray diffraction Fourier fingerprint spectra and characteristic diffraction peaks were obtained. There were some differences among the spectra of the extracts, but the characteristic diffraction peaks were obvious. The experimental result indicated that X-ray diffraction Fourier fingerprint spectra can be used to identify and analyze the Chinese traditional herb Lygodium japonicum (Thunb.) Sw.
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 03/2006; 29(2):123-6.