Yi Xiong

Publications (2)5.68 Total impact

• Article: Synthesis and cytotoxicity of racemic isodeoxypodophyllotoxin analogues with isoprene-derived side chains.

  Yu Zhao, Ju Hong Feng, Hong Xia Ding, Yi Xiong, Christopher H K Cheng, Xiao Jiang Hao, Yong Min Zhang, Yuan Jiang Pan, Françoise Guéritte, Xiu Mei Wu, Hua Bai, Joachim Stöckigt
  [show abstract] [hide abstract]
  ABSTRACT: A series of isodeoxypodophyllotoxin (5) analogues, 26-38, with various isoprene-derived side chains at the E-ring were designed and synthesized. For comparison, compound 39, with a benzyloxy group on the E-ring, and six D-ring opened analogues, 40-45, were also prepared. All the synthetic compounds were evaluated for their cytotoxic activities in vitro against seven cultured human tumor cell lines. Compounds 27, 43, and 44 were more cytotoxic than etoposide on BEL-7404, A549, and HL-60 cell lines, respectively. However, none of the synthetic isodeoxypodophyllotoxins were more cytotoxic than podophyllotoxin (1).
  Journal of Natural Products 09/2006; 69(8):1145-52. · 3.13 Impact Factor
• Article: Isolation, synthesis, and anti-tumor activities of a novel class of podocarpic diterpenes.

  Yi Xiong, Kuiwu Wang, Yuanjiang Pan, Hongxiang Sun, Jue Tu
  [show abstract] [hide abstract]
  ABSTRACT: A novel unusual 17-carbon diterpenoid, named (+)-7-deoxynimbidiol, was isolated from the stalks of Celastrus hypoleucus (Oliv.) Warb. Its racemate and derivatives were synthesized, and the inhibitory activities of these compounds against four cultured human-tumor cell lines were evaluated. The structure-activity relationship was discussed.
  Bioorganic & Medicinal Chemistry Letters 03/2006; 16(4):786-9. · 2.55 Impact Factor