Zhen Xue

Fudan University, Shanghai, Shanghai Shi, China

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Publications (3)5.99 Total impact

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    ABSTRACT: Of 52 patients with recurrent tuberculosis in Shanghai, People's Republic of China, 32 (61.5%) had isolates in which genotype patterns of Mycobacterium tuberculosis differed between first and second episodes. This result indicates that exogenous reinfection is common in an area with a high incidence of tuberculosis.
    Emerging infectious diseases 12/2006; 12(11):1776-8. · 5.99 Impact Factor
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    ABSTRACT: To investigate the main cause of drug-resistant tuberculosis. Clinic isolates of Mycobacterium tuberculosis from 1996 to 2004 in Shanghai were analyzed and the proportion of isolates from new cases (the proxy of primary drug-resistance) and retreatment cases (the proxy of acquired drug-resistance) were calculated. Mycobacterial interspersed repetitive units (MIRU) genotyping was performed and analyzed on pairs of isolates of Mycobacterium tuberculosis from 16 recurrent patients with drug-resistant tuberculosis. Of all 8 120 isolates of Mycobacterium tuberculosis from new cases, 707 isolates (8.7%) were drug resistant. Of all 610 isolates from retreatment cases, 150 isolates (24.6%) were drug resistant. Primary drug resistance accounted for 82.5% (707/857) of all drug resistant isolates. Based on the MIRU genotypes, 13 of all 16 recurrent drug-resistant patients were reinfected with new drug-resistant strain of Mycobacterium tuberculosis. Primary drug-resistance is the main cause of drug-resistant tuberculosis.
    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 03/2006; 29(2):75-8.
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    ABSTRACT: To study the contribution of exogenous reinfection to tuberculosis recurrence. Mycobacterium tuberculosis isolates from patients who had experienced 2 successive tuberculosis episodes during the years from January 1999 to March 2004 were genotyped by mycobacterial interspersed repetitive units (MIRU) method. The cause of tuberculosis recurrence was determined by comparing the MIRU pattern of Mycobacterium tuberculosis isolates responsible for different tuberculosis episodes from patients. Of 37 qualified patients with recurrent tuberculosis, the isolates from 25 patients in their two tuberculosis episodes showed different MIRU patterns, indicating that 68% recurrent patients were due to exogenous reinfection. The exogenous reinfection rate decreased with the age from 3/3 (under 30 years) to 73% (11/15, 30 to 60 years) and 58% (11/19, over 60 years). The frequency of exogenous reinfection increased with the tuberculosis recurrent interval. Within 6 months, the exogenous reinfection accounted for 58% (7/12) of all the recurrence, while for the time more than one year, the percentage increased to 79% (11/14). Exogenous reinfection was a major cause of tuberculosis recurrence in Shanghai. MIRU genotyping method is useful to study the cause of tuberculosis recurrence.
    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 03/2006; 29(2):79-82.