Chun Yu

National Chiao Tung University, Hsin-chu-hsien, Taiwan, Taiwan

Are you Chun Yu?

Claim your profile

Publications (13)8.57 Total impact

  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Multivariable Analysis Methods have been used widely in Spectroscopy Analysis. Partial least square (PLS) and principal component analysis (PCA) are the two most popular methods due to their excellent ability in data components analysis and results prediction. This work derived 1D/2D PLS and 1D/2D PCA based on the viewpoint of three-layer artificial neural networks, and uses theoretical proving to figure out the essences of these two methods. Two 2D experimental dataset was used to verify the calibration and prediction ability, furthermore, the similarity and dissimilarity of PLS and PCA. The finding showed that both the 1D/2D PLS and 1D/2D PCA methods use maximum covariance and minimum sum of square error to figure out the relationship between independent and dependent variables. The dissimilarity is that, weight vectors calibration of PLS is cross-correlation, and that of PCA is autocorrelation. The difference causes that the PCA method would keep more principal characters than PLS under insufficient sample among and provides better calibration ability. PLS would provide higher performance in prediction under sufficient sample among. For the needs of system implementation of spectroscopic measurement and analysis, this study designed "Multivariate Analysis Toolkits for LabVIEW" for the convenient implementation in automatic measurement system integration.
    Biomedical Engineering Applications Basis and Communications 04/2013; 25(02). · 0.23 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Asthma is a chronic disease that is commonly suffered by children. Asthmatic children have a lower quality of life than other children. Physicians and pediatricians recommend that parents record the frequency of attacks and their symptoms to help manage their children's asthma. However, the lack of a convenient device for monitoring the asthmatic condition leads to the difficulties in managing it, especially when it is suffered by young children. This work develops a wheeze detection system for use at home. A small and soft stethoscope was used to collect the respiratory sound. The wheeze detection algorithm was the Adaptive Respiratory Spectrum Correlation Coefficient (RSACC) algorithm, which has the advantages of high sensitivity/specificity and a low computational requirement. Fifty-nine sound files from eight young children (one to seven years old) were collected in the emergency room and analyzed. The results revealed that the system provided 88% sensitivity and 94% specificity in wheeze detection. In conclusion, this small soft stethoscope can be easily used on young children. A noisy environment does not affect the effectiveness of the system in detecting wheeze. Hence, the system can be used at home by parents who wish to evaluate and manage the asthmatic condition of their children.
    Sensors 01/2013; 13(6):7399-413. · 2.05 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Preterm birth is the leading cause of perinatal morbidity and mortality. Fetal fibronectin (fFN), a glycoprotein in the extracellular matrix of the amniotic membranes, is the most powerful biomarker for predicting the risk of preterm birth. Biosensors using the surface plasmon resonance (SPR) response are potentially useful in quantitatively measuring molecules. We established a standard calibration curve of SPR intensity against fFN concentration and used the SPR-based biosensor to detect fFN concentrations in the cervicovaginal secretions of pregnant women between 22 and 34 weeks of gestation. The calibration curve extends from 0.5 ng/mL to 100 ng/mL with an excellent correlation (R(2) = 0.985) based on standard fFN samples. A cutoff value of 50 ng/mL fFN concentration in commercial ELISA kits corresponds to a relative intensity of 17 arbitrary units (a.u.) in SPR. Thirty-two pregnant women were analyzed in our study. In 11 women, the SPR relative intensity was greater than or equal to 17 a.u., and in 21 women, the SPR relative intensity was less than 17 a.u. There were significant differences between the two groups in regular uterine contractions (p = 0.040), hospitalization for tocolysis (p = 0.049), and delivery weeks (p = 0.043). Our prospective study concluded that SPR-based biosensors can quantitatively measure fFN concentrations. These results reveal the potential utility of SPR-based biosensors in predicting the risk of preterm birth.
    Sensors 01/2012; 12(4):3879-90. · 2.05 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Preterm birth is the main cause of perinatal morbidity and mortality throughout the world. Fetal fibronectin (fFN) is one type of glycoprotein detected in the interface of the choriodecidual junction. Preterm labor is related to the disruption of the choriodecidual junction and thus fFN releases in the ectocervix or posterior vaginal fornix. Quan-tization of fFN can assist the diagnosis and prevention of preterm birth. In this work, we developed an immunoassay, the immunomagnetic reduction (IMR), to quantitatively detect fFN. It was found that the low detection limit for fFN via IMR is less than 10 ng/ml, which is much lower than clinic criteria 50 ng/ml. In addition to the high sensitivity, IMR assay shows such merits as low cost and high reliability for detecting fFN.
    Biomedical Engineering Applications Basis and Communications 12/2011; 23(4):273-278. · 0.23 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Preterm birth is the main cause of perinatal morbidity and mortality throughout the world. Fetal fibronectin (fFN) is one type of glycoprotein detected in the interface of the choriodecidual junction. Preterm labor is related to the disruption of the choriodecidual junction and thus fFN releases in the ectocervix or posterior vaginal fornix. Quan-tization of fFN can assist the diagnosis and prevention of preterm birth. In this work, we developed an immunoassay, the immunomagnetic reduction (IMR), to quantitatively detect fFN. It was found that the low detection limit for fFN via IMR is less than 10 ng/ml, which is much lower than clinic criteria 50 ng/ml. In addition to the high sensitivity, IMR assay shows such merits as low cost and high reliability for detecting fFN.
    Biomedical Engineering Applications Basis and Communications 08/2011; 23(4):273-278. · 0.23 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Cardiotocography (CTG) is a frequently used technique of fetal monitoring to evaluate the well being of the fetus during pregnancy and in labor. The surveillance technique depends on the analysis of characteristic fetal heart rate patterns and uterine contractions. Computerized analyses can mitigate the intra-observer and inter-observer variability of visual CTG recording explanation, decrease the examination time, and the need of additional tests for fetal health. Several studies also showed that the signal processing techniques could help to determine the fetal heart rate (FHR) patterns, but all of them were only suitable for physicians. Following the criteria and consensuses of National Institute of Child Health and Human Development in April 2008, we developed a LabVIEW based FHR and uterine contraction (UC) pattern analysis software. This software has great potential for home-care use. The signal processing methods utilized in this study are median filter and peak/valley detection method. The analysis performance was verified by nineteen pregnant women's data. The accuracy of FHR baseline, baseline variability, early deceleration, UC frequency and NST all reach 100%. The accuracy of acceleration frequency reaches 90%. The accuracy of late and variable decelerations reaches 95%.
    Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 01/2009; 2009:2567-70.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Because of the rapid aging population in Taiwan and the trend of fewer children, people are looking into technical solutions for continuous/intermittent monitoring of vital signs in the home setting environment and the interactions between family members. In this study we developed a smart medical services system for managing chronic disease, called Citizen Telemedical Care service System (CTCS). The system integrates biosignal measurement, hypertension risk estimation expert system, clinic appointment service, video communication service, medical assistance referral, health frequency program record, and health/hygiene education. The demo version CTCS is exhibited in the center of INSIGHT opened for visit and trial use. In order to verify the demand and acceptability of the system and services, we have interviewed 251 volunteers with a questionnaire survey with the help from Taipei City Government. The results showed that people have positive expectation about the service program for health care and the capability of home devices. They also expressed high motivation on learning to use the system and to participate in the program. According to the evaluation results, the system is processing a small user test led by Taipei City Government, in order to further verify the acceptability and satisfaction of the system.
    Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 01/2009; 2009:6095-8.
  • [Show abstract] [Hide abstract]
    ABSTRACT: The soft sensors for monitoring respiratory and heart sound were composed of polyurethane and microphones. In this study, silica was blended with polyurethane to change the hardness of the chambers. The hardness would influence the frequency response of the sensors. The material composed of 60 phr silica was chosen to make the chamber of the sensor. It had higher hardness and resulted in the flatten frequency response across the range of 100–1200 Hz. By the filter band designed for heart sound and respiratory sound signal, the heart sound and respiratory sound can be collected. The measured sound was verified by the physician and showed no distortion.
    Biomedical Engineering Applications Basis and Communications 01/2009; 21(06). · 0.23 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Because of the rapid aging population in Taiwan and the trend of fewer children, people are looking into technical solutions for continuous/intermittent monitoring of vital signs in the home setting environment and the interactions between family members. In this study, we have designed and implemented a home medical gateway system to connect the home-care side and the health informatics side. The home-care part provides five vital signs monitoring and on-line feedback message. Users are allowed to browse their records and read the received health information (e.g. physical checkup, health education, preventive inoculation...etc.) on the Flash based interface. This study also evaluated the practicability of the home gateway system. The number of interviewees is twenty. The analysis results show the positive user feedback of the system, and have high potential to promote the quality of patient’s life. An example case of obstructed sleep apnea (OSA) patient has been studied with this system. The result shows that the gateway system can help the OSA patient to monitor and improve their sleep quality.
    01/2009;
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Bio-plasmonics is proposed for the research and development of novel devices, which use biomolecules as a part of the plasmon oscillation system to actively interact with nano/micro structure. We have reported a novel design of surface plasmon resonance (SPR) device and system, which uses alternative dielectric layers to enhance the SPR signal quality and modulate its resonant position. The use of biomolecular thin film, such as DNAs or proteins, in this design can result in resonant condition of wavelength changes and thus can be detected by using nano-grating in the scattering mode with enhanced feature due to resonance. According to our calculation, it can provide ultra sensitivity system (dLx/dn) of 108 for biosensor applications. The fundamental SPR principle and extended application of these fundamental principles and novel devices, including screening and diagnosis, will be discussed SPR-system to control is the ability. SPR-system has the ability to detect, in near real-time, the concentration of a target analyte and biosensing is viewed as a key application domain for this new technology.
    Eighth International Conference on Intelligent Systems Design and Applications, ISDA 2008, 26-28 November 2008, Kaohsiung, Taiwan, 3 Volumes; 01/2008
  • [Show abstract] [Hide abstract]
    ABSTRACT: We demonstrate the photoluminescence (PL) characteristics of a two-layer organic emitter on the corrugated structure of nano-meter scale. A strong emission was observed on certain viewing angles which come from the surface plasma resonance. Different organic materials provide a broadband radiation which improves the PL intensity.
    Lasers and Electro-Optics - Pacific Rim, 2007. CLEO/Pacific Rim 2007. Conference on; 10/2007
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The effect of coupled mode surface plasmon polaritons (SPPs) on the active emission of a nanostructure grating with organic semiconductor material, Alq(3), on the surface was investigated in this study. We report surface plasmon grating coupled emission (SPGCE) from excited organic layer on metal grating in both organic/metal (2-Layer) and organic/metal/organic/metal (4-Layer) structures. The dispersion relation was obtained from angle-resolved photoluminescence measurement. The resultant emission intensity can have up to 6 times enhancement on the 4- Layer device and the Full-Width Half-Maximum (FWHM) is less than 50 nm. The combination of SPPs on organic/metal interface allows specific directional emission and color appearance of Alq(3) fluorophores. Potential applications of such an active plasmonics with enhanced resonant energy emission due to interactions on the organic/metal nano-grating as biosensor were presented and discussed.
    Optics Express 10/2007; 15(18):11608-15. · 3.55 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: This paper is intended to demonstrate the effect of coupled surface plasmon polaritons (SPPs) on the optical response of a one-dimensional metal grating nanostructure patterned by electron beam lithography (EBL) on the silicon surface. Variations of the structure parameters allow continuously tuning of these high-transmission bands across the nanostructure plasmon resonance. This phenomenon gives rise to a selective spectral response and a local field enhancement which can be used in the context of nano-optics. We have examined the emission and reflectance spectra through various fabricated structure layers to determine the emissive angle in SPPs modes. The presented results show that the enhanced reflectance through grating nanostructures is important for such a planar design of novel optical biosensor.
    Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 02/2006; Suppl:6521-4.