Kátia Silva Martinho

Universidade Santo Amaro (UNISA), San Paulo, São Paulo, Brazil

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Publications (8)0.84 Total impact

  • LV Bonamin, K Martinho, AL Nina
    Focus on Alternative and Complementary Therapies 01/2010; 5(1):86-86.
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    ABSTRACT: Background: Recently, the use of homeopathy in veterinary medicine has grown significantly, mainly for farm animal practice, because of its usefulness in organic production and low cost. There is a wide range of veterinary products available in the marketoften used in females. However, the effect of these products in the litter and derived products for human consummation is completely unknown. Aims: this study sought to develop an experimental model to study the putative effects of high diluted substances in newborns after chronic exposure of females. Methods: based on previous studies, the chosen test substance was dexamethasone 15cH; adult female Balb/c mice were divided into 4 groups: a) treated with PBS (control); b) treated with dexamethasone 15 cH; c) treated with dexamethasone 15cH + dexamethasone 4 mg/kg and d) treated with dexamethasone 4 mg/kg. All medicines were administered subcutaneously, 3 times a week, in females from the first day of pregnancy up to the 20th day after parturition (end of lactation period). TDevelopment of the offspring was evaluated daily for 15 days after birth. Parameters evaluated were: female and offspring viability, number of newborns, time for eye opening, pinna opening, fur growth and postural reflex. Results: the group treated with dexamethasone 15cH showed 39% increase in mortality rate 39 days after the beginning of treatment and 35% increase in fetal mortality at the end of gestation (p=0.0049). Females treated with dexamethasone 4mg/kg + dexamethasone 15cH showed 100% of fetal mortality. After parturition newborn survival in animals exposed to dexamethasone 4 mg/kg was higher than the control (p=0.0002). All other parameters of neonatal development were unchanged among groups. Conclusions: these data point to adverse effect when using high diluted dexamethasone during gestation detectable by this experimental model in Balb/c mice.
    International Journal of High Dilution Research. 01/2009;
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    ABSTRACT: The regenerative hepatic process has been of interest since Ancient Greek time, according to the Prometheus myth. Nowadays, hepatic regeneration study is incontestable due to its clinical importance. For all the characteristics mentioned below, studies involving hepatic regeneration and hepatic carcinogenesis are a good basic research model to study biological effects of ultra high dilutions in living organisms. It is well known the majority of the liver is made from hepatocytes, classified as “stable cells”, which means that under normal conditions, they have low “turn over” or low renew rate, with mitotic activity up to 1% (Cotran et al., 2004). However, when a reduction of functional liver parenchyma occurs, due to a lesion or partial ablation of this organ, the proliferation activity increases until 100% of its parenchyma is regenerated. Many serious hepatic diseases such as cirrhosis and hepatocellular carcinoma are a disturbance result of the regenerative process. In the last years, much effort has been dedicated to understand the molecular mechanisms coordinating these processes.
    12/2007: pages 83-96;
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    ABSTRACT: Os efeitos terapêuticos e patogenéticos do Dolichos pruriens foram avaliados usando modelos experimentais bem estabelecidos pela farmacologia tradicional para avaliar parâmetros comportamentais, através de métodos “Campo aberto” e “Grooming”. O objetivo desse estudo foi testar se os modelos experimentais propostos eram instrumentos adequados para: a) estudar os possíveis efeitos terapêuticos do Dolichos pruriens 6CH, 9CH, 12CH e 30CH na coceira induzida e; b) sugerir um modelo de patogenesia em ratos, usando as potências 6CH e 30CH para a mesma substância.
    International Journal of High Dilution Research. 01/2006;
  • International Journal of High Dilution Research. 01/2006;
  • International Journal of High Dilution Research. 01/2006;
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    ABSTRACT: Atropa belladonna and Echinacea angustifolia have been used in homeopathy as modulators of inflammatory processes, in simple potency or 'accord of potencies', as recommended by homotoxicology. We evaluated their effects on leukocyte migration and macrophage activity induced by experimental peritonitis in vivo. Mice were injected (i.p.) with LPS (1.0mg/kg) and treated (0.3ml/10g/day, s.c.) with different commercial forms of these medicines. Echinacea angustifolia D4--a simple potency preparation--and Belladonna Homaccord, Belladonna Injeel, Belladonna Injeel Forte, Echinacea Injeel and Echinacea Injeel Forte--all in 'accord of potencies'--were tested. The association of A. belladonna and E. angustifolia in 'accord of potencies' produced an increase of polymorphonuclear cell migration (Kruskal-Wallis, P = 0.03) and a decrease of mononuclear cell percentages (Kruskal-Wallis, P < or = 0.04), when compared with control, mainly in preparations containing low potencies. The proportion of degenerate leukocytes was lower in the treated groups, compared to a control group (P < or = 0.05). The treated groups showed increased phagocytosis (P < or = 0.05), mainly in preparations containing high potencies. Our results suggest that A. belladonna and E. angustifolia, when prepared in 'accord of potencies', modulate peritoneal inflammatory reaction and have a cytoprotective action on leukocytes.
    Homeopathy 10/2004; 93(4):193-8. · 0.84 Impact Factor
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    ABSTRACT: We evaluated the interaction of dexamethasone 10(-17) and 10(-33) M (equivalent to 7cH and 15cH) with dexamethasone in pharmacological concentrations, using as experimental models: acute inflammation induced by carrageenan, Ehrlich ascitic tumour, and migration of tumour infiltrating leukocytes (TIL). Male adult BALB/c mice (n=7 per group) were used in all experiments. Carrageenan (1%) was injected into the footpad for oedema evaluation and into the peritoneal cavity (i.p.), for differential counting of inflammatory cells. Ehrlich ascitic tumour cells (10(7) viable cells/ml) were injected i.p. and tumour cells were counted after 6 days, by the Trypan blue exclusion method. The differential TIL was counted using smears stained by hematoxylin-eosin. Treatments were made immediately after carrageenan inoculation or once a day, during Ehrlich tumour development, until the animals were killed. Animals were treated with the following preparations: (1) phosphate buffer saline (PBS) solution; (2) dexamethasone (0.5 mg/kg for inflammation model or 4mg/kg for tumour model) mixed with dexamethasone 7cH or 15cH; (3) dexamethasone (same doses) mixed in PBS. Homeopathic dexamethasone partially blocked the anti-inflammatory effect of pharmacological dexamethasone with regard to paw oedema (two-way ANOVA, P < 0.0008) and polymorphonuclear cell migration (chi2, P=0.0001). No important differences were observed between experimental and control groups, in relation to Ehrlich tumour cells viability or count, or bodyweight, but potentised dexamethasone restored control levels of TIL viability, compared to mice treated with pharmacological doses of dexamethasone (chi2, P< or = 0.001). The results demonstrate that a potentised substance may change its own pharmacological effects and suggest that ultradilutions effects act mostly on host response.
    British Homoeopathic journal 11/2001; 90(4):198-203.