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Publications (4)1.58 Total impact

  • A M Ciraj, P Vinod, G Sreejith, K Rajani
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    ABSTRACT: Clinical failure of clindamycin therapy has been reported due to multiple mechanisms that confer resistance to macrolide, lincosamide and streptogramin antibiotics. This study was undertaken to detect the presence of inducible clindamycin resistance among clinical isolates of staphylococci. The detection of inducible clindamycin resistance was performed by D-test using erythromycin and clindamycin discs as per CDC guidelines. Among the 244 clinical isolates of staphylococci studied, 32 (13.1%) showed inducible clindamycin resistance and belonged to the MLSBi phenotype. Among the MLS B i phenotypes, 10 isolates were methicillin-resistant Staphylococcus aureus (38.4% of the total MRSA), 16 were methicillin-sensitive Staphylococcus aureus (12.9% of the total MSSA) and 6 were coagulase-negative staphylococci (6.3% of the total CONS). The test for inducible resistance to clindamycin should be included in the routine antibiotic susceptibility testing, as it will help in guiding therapy.
    Indian Journal of Pathology and Microbiology 01/2009; 52(1):49-51. · 0.68 Impact Factor
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    ABSTRACT: Certain 4′-(4′′-substituted phenyl)-4-methylfurobenzopyrones were synthesized and evaluated for antibacterial activity. Six of the synthesized compounds were also screened for their antiinflammatory activity. Substituted resorcinols were condensed with ethyl acetoacetate to afford different coumarins (2a-c). Various substituted phenacyl bromides (4a-g) were prepared by the bromination of para-substituted acetophenones. The coumarins (2a-c) and phenacyl bromides (4a-g) were condensed to give oxoethers (5a-s). These were cyclised by using 1 M sodium hydroxide to afford the desired furobenzopyrone derivatives (FCa-s). All the compounds have been evaluated for their antibacterial activity against different strains of gram positive and gram negative bacteria. All the compounds have shown good activity against Pseudomonas aeruginosa . Compounds, 3-(4-chlorophenyl)-5-methylfuro-[3,2-g][1]benzopyran-7-one, 3-(4-chlorophenyl)-5,9-dimethylfuro[3,2-g][1]benzopyran-7-one and 4,5-dimethyl-3-phenylfuro[3,2-g][1]benzopyran-7-one (FCe, FCi, FCn) were active against E. coli . A few compounds showed moderate activity against Bacillus subtilis also. Antiinflammatory activity of six selected compounds was also tested using the carrageenan-induced rat paw oedema method. Among them, 5-methyl-3-p-tolylfuro[3,2-g][1]benzopyran-7-one (FCg) showed excellent activity. 5-Methyl-3-phenylfuro[3,2-g][1]benzopyran-7-one (FCa) and 4,5-dimethyl-3-(4-nitrophenyl)-furo[3,2-g][1]benzopyran-7-one (FCc) showed activity comparable to that of the standard drug ibuprofen.
    Indian Journal of Pharmaceutical Sciences. 01/2007;
  • Indian Journal of Medical Microbiology (ISSN: 0255-0857) Vol 24 Num 4. 01/2007;
  • Indian Journal of Medical Microbiology 11/2006; 24(4):300. · 0.91 Impact Factor