T Vetrichelvan

Publications (2)0 Total impact

• Article: Antibacterial activity of mushroom Osmoporus odoratus

  R Sivakumar, T Vetrichelvan, N Rajendran, M Devi, K Sundaramoorthi, ASK Shankar, S Shanmugam
  [show abstract] [hide abstract]
  ABSTRACT: The petroleum ether, chloroform, acetone and water extracts of mushroom Osmoporus odoratus were selected for examine the antibacterial activity against Staphylococcus aureus, Streptococcus pyogenes, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa by disc diffusion method using Muller Hinton agar media. And the extracts were compared with that of standard ampicillin (30 µg) and chloramphenicol (30 µg). The water extract alone showed antibacterial activity against the tested organisms and the results were comparable with that of ampicillin rather than chloramphenicol.
  Indian Journal of Pharmaceutical Sciences. 01/2006;
• Source

  Available from: sphinxsai.com

  Article: Formulation and Evaluation of Sustained Release Matrix Tablets of Losartan potassium

  S Shanmugam, Ramya Chakrahari, K Sundaramoorthy, T Ayyappan, T Vetrichelvan
  [show abstract] [hide abstract]
  ABSTRACT: The objective of the present study was to develop a sustained release matrix tablets of Losartan potassium, an anti hypertensive drug. The sustained release tablets were prepared by wet granulation and formulated using different drug and polymer ratios, formulations such as F1 to F9. Hydrophilic polymer like Hydroxypropyl methylcellulose (HPMC), hydrophobic polymer like Ethyl Cellulose(EC) and natural polymer like Xanthan Gum(XG) were used. Compatibility of the drug with various excipients was studied. The compressed tablets were evaluated and showed compliance with Pharmacopoeial limits. The optimized formulation(F3) on the basis of acceptable tablet properties and in vitro drug release. The resulting formulation produced robust tablets with optimum hardness, consistent weight uniformity and friability. All tablets but one exhibited gradual and near completion sustained release for Losartan potassium, and 96.45% released at the end of 10h. The results of dissolution studies indicated that formulation F3 (drug to polymer 1:1.5), the most successful of the study, exhibited drug release pattern very close to theoretical release profile. A decrease in release kinetics of the drug was observed on increasing polymer ratio. Applying exponential equation, all the formulation tablets(except F3) showed diffusion-dominated drug release. The mechanism of drug release from F3 was diffusion coupled with erosion.
  International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN. 02/2002; 3:974-4304.