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Publications (3)0.9 Total impact

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    ABSTRACT: High dose steroids and intravenous immunoglobulins are the gold treatment of acute immune thrombocytopenic purpura, before splenectomy for severe and refractory forms of the disease. Authors report two cases of severe acute refractory immune thombocytopenia with a dramatic response to plasma exchanges. The first case was an idiopathic form, complicated by hemorragic peritoneal effusion. After failure of steroids, intravenous immunoglobulins and splenectomy and 2 courses of rituximab, plasmapheresis normalized in 3 days platelet count. In the second observation, ITP was associated to systemic lupus with antiphospholipids antibodies and multivisceral failure, despite steroids and intravenous immunoglobulins. After 3 plasma exchanges, platelet count was normalized, and the patient is under remission after 24 months follow-up. Plasmapheresis must be evaluated as an emergency treatment in refractory forms of acute immune thrombocytopenic purpura.
    La Revue de Médecine Interne 11/2005; 26(10):824-6. · 0.90 Impact Factor
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    ABSTRACT: Introduction. – High dose steroids and intravenous immunoglobulins are the gold treatment of acute immune thrombocytopenic purpura, before splenectomy for severe and refractory forms of the disease. Authors report two cases of severe acute refractory immune thombocytopenia with a dramatic response to plasma exchanges.Exegesis. – The first case was an idiopathic form, complicated by hemorragic peritoneal effusion. After failure of steroids, intravenous immunoglobulins and splenectomy and 2 courses of rituximab, plasmapheresis normalized in 3 days platelet count. In the second observation, ITP was associated to systemic lupus with antiphospholipids antibodies and multivisceral failure, despite steroids and intravenous immunoglobulins. After 3 plasma exchanges, platelet count was normalized, and the patient is under remission after 24 months follow-up.Conclusion. – Plasmapheresis must be evaluated as an emergency treatment in refractory forms of acute immune thrombocytopenic purpura.
    Revue De Medecine Interne - REV MED INTERNE. 01/2005; 26(10):824-826.
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    ABSTRACT: Dyscalcemias are a common problem in the emergency department. Calcium homeostasis is a result of the collaboration between bone, kidney and intestinal tract mediated by an hormonal system involving parathyroid hormone and vitamin D. It seems better to analyze ionized calcium or to correct total calcemia according to underlying conditions. Serum abnormalities can be associated with dramatic visceral consequences including a lethal risk. The severity of symptoms is correlated with both the magnitude and the rapidity of the onset of the troubles, and should guide treatments. Etiologies of dyscalcemias are numerous and often multifactorial. In hypercalcemia, 90% of them are hyperparathyroidism or malignancy. Emergency treatment is based on rehydratation, diphosphonates and sometimes calcitonin. In hypocalcemia, treatment starts with calcium supplementation. In both situations, an etiologic treatment should be considered.
    Réanimation. 11/2002; 11(7).