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Publications (12)19.95 Total impact

  • Annales de Dermatologie et de Vénéréologie 04/2013; 140:S38. · 0.60 Impact Factor
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    ABSTRACT: Leishmania major is the only species of Leishmania known to cause cutaneous leishmanisis (CL) in Mali. We amplified Leishmania DNA stored on archived Giemsa-stained dermal scraping slides obtained from self-referral patients with clinically suspected CL seen in the Center National D'Appui A La Lutte Contre La Maladi (CNAM) in Bamako, Mali, to determine if any other Leishmania species were responsible for CL in Mali and evaluate its geographic distribution. Polymerase chain reaction (PCR) amplification was performed using a Leishmania species-specific primer pair that can amplify DNA from L. major, L. tropica, L. infantum, and L. donovani parasites, possible causative agents of CL in Mali. L. major was the only species detected in 41 microscopically confirmed cases of CL from five regions of Mali (Kayes, Koulikoro, Ségou, Mopti, and Tombouctou). These results implicate L. major as the predominant, possibly exclusive species responsible for CL in Mali.
    The American journal of tropical medicine and hygiene 01/2013; · 2.53 Impact Factor
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    ABSTRACT: Pruritus is a symptom frequently encountered in dermatology consultations. For practitioners working in a tropical environment, particularly in Africa, the diagnosis of pruritus remains a constant problem. The aim of this study was to describe the epidemioclinical aspects and the etiologies of pruritus encountered at the dermatological hospital in Bamako. We conducted a prospective survey on a cohort of patients attending the Department of Dermatology at the Centre National d’Appui (CNAM-Ex Institut Marchoux) in the Fight against Disease over a 1-year period (June 1, 2009–May 31, 2010). Consequently, the study included every patient, whatever their age and gender, that agreed to take part in the survey and whose main reason for attending for a consultation was “pruritus.” The clinical and biological data were entered and analyzed using Epi Info software, version 6.04 fr. A total of 232 patients (163 women, 69 men) attended because of pruritus out of 1761 overall patients (i.e., a prevalence of 13.17%). The mean age of the patients was 33 ± 19 years. Dermatological causes represented 95% of the etiologies. This work allowed us to observe the systemic causes of pruritus in the dermatological environment in Mali and greater likelihood of black women to attend because of pruritus.
    International journal of dermatology 11/2012; 51(s1). · 1.18 Impact Factor
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    ABSTRACT: Dermatitis of the folds (intertrigo) is a frequent reason for attending consultations, particularly in Africa, where the hot and humid climate constitute an aggravating factor. It is a complex pathology with multiple and intricate etiologies. The aim of this study was to describe epidemiological and etiological aspects of dermatitis of the folds in black-skinned subjects in Bamako (Mali). We conducted a transversal descriptive survey of cases of localized dermatitis of the folds of the skin in dermatology clinics in Bamako. In total, 141 cases of intertrigo were identified: 96 female subjects (68%) and 45 male subjects. The average age of patients was 30 ± 18 years (2–80 years). The majority of patients were seen between March and June; 52% of patients had already received treatment before the consultation. The lesions affected skin folds of the groin area and/or area between the buttocks in 95 patients (57.4%), and folds of the armpits and area under the breasts were affected in 46 cases (42.6%). Eczema, erythrasma, and fungal disease were the most frequently observed pathologies. Of interest to this study is the topographical approach that a dermatologist must adopt when diagnosing certain forms of dermatitis. In populations with specific cultural practices, apart from a thorough knowledge of these specific factors, treatment of these conditions requires certain harmful attitudes and behaviors to be abandoned.
    International journal of dermatology 11/2012; 51(s1). · 1.18 Impact Factor
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    ABSTRACT: Résumé La dermatose des plis ou intertrigo est un motif fréquent de consultation notamment en Afrique où le climat chaud et humide constitue un facteur aggravant. C’est une pathologie complexe aux étiologies multiples et intriquées. Le but de ce travail était de décrire les aspects épidémiologiques et étiologiques des dermatoses des plis chez les sujets à peau noire à Bamako (Mali). Nous avons mené une enquête transversale descriptive des dermatoses localisées aux plis en milieu dermatologique à Bamako (Mali). Au total, 141 cas d’intertrigo ont été identifiés : 96 sujets de sexe féminin (68%) et 45 de sexe masculin. L’âge moyen des malades était de 30 ± 18 ans (2–80 ans). La majorité des malades ont consulté entre les mois de mars et Juin; 52% des malades avaient déjà reçu un traitement avant la consultation. Les lésions intéressaient les plis inguinaux et ou inter-fessiers chez 95 patients (57,4%), les plis axillaires et sous-mammaires chez 46 malades (42,6%). L’eczéma, l’érythrasma et les mycoses étaient les pathologies les plus fréquemment observées. L’intérêt de ce travail repose sur l’approche topographique qu’un dermatologue doit adopter pour conduire le diagnostic de certaines dermatoses. Dans les populations ayant des pratiques culturelles spécifiques, la prise en charge de ces affections nécessite, outre une bonne connaissance de ces spécificités, l’abandon des attitudes et comportements néfastes.
    International journal of dermatology 11/2012; 51(s1). · 1.18 Impact Factor
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    ABSTRACT: Résumé Le prurit est un symptôme fréquemment rencontré en consultation dermatologique. Pour le praticien exerçant en milieu tropical, notamment en Afrique, le diagnostic du prurit demeure une problématique constante. Le but de ce travail était de décrire les aspects épidémio-cliniques et les étiologies du prurit en milieu hospitalier dermatologique à Bamako. Nous avons mené une enquête prospective sur une cohorte de malades consultant dans le service de Dermatologie du Centre National d’Appui à la lutte contre la Maladie (CNAM-Ex Institut Marchoux) sur une période d’un an (01/06/2009 au 31/05/2010). Ainsi, ont été inclus dans l’étude, tous malades, quelque soit l’âge et le sexe, acceptant de participer à l’enquête et dont le motif principal de consultation était le « prurit ». Les données cliniques et biologiques ont été saisies et analysées à l’aide du logiciel Epi Info version 6.04 fr. Au total, 232 malades (163 femmes, 69 hommes) ont consulté pour prurit sur 1761 malades consultants, soit une prévalence de 13.17%. L’âge moyen des malades était de 33 ± 19 ans. Les causes dermatologiques représentaient 95% des étiologies. Ce travail nous a permis de noter la rareté des causes systémiques du prurit en milieu dermatologique au Mali et une plus grande susceptibilité de la femme noire à consulter pour prurit.
    International journal of dermatology 11/2012; 51(s1). · 1.18 Impact Factor
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    ABSTRACT: Immunity to sand fly saliva in rodents induces a T(H)1 delayed-type hypersensitivity (DTH) response conferring protection against leishmaniasis. The relevance of DTH to sand fly bites in humans living in a leishmaniasis-endemic area remains unknown. Here, we describe the duration and nature of DTH to sand fly saliva in humans from an endemic area of Mali. DTH was assessed at 24, 48, 72, and 96 hours post bite in volunteers exposed to colony-bred sand flies. Dermal biopsies were obtained 48 hours post bite; cytokines were quantified from peripheral blood mononuclear cells (PBMCs) stimulated with sand fly saliva in vitro. A DTH response to bites was observed in 75% of individuals aged 1-15 years, decreasing gradually to 48% by age 45, and dropping to 21% thereafter. Dermal biopsies were dominated by T lymphocytes and macrophages. Abundant expression of IFN-γ and absence of T(H)2 cytokines establishes the T(H)1 nature of this DTH response. PBMCs from 98% of individuals responded to sand fly saliva. Of these, 23% were polarized to a T(H)1 and 25% to a T(H)2 response. We demonstrate the durability and T(H)1 nature of DTH to sand fly bites in humans living in a cutaneous leishmaniasis-endemic area. A systemic T(H)2 response may explain why some individuals remain susceptible to disease.Journal of Investigative Dermatology advance online publication, 20 September 2012; doi:10.1038/jid.2012.315.
    Journal of Investigative Dermatology 09/2012; · 6.19 Impact Factor
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    ABSTRACT: In dark skin patients, hypopigmentation is the most disfiguring condition. Very few studies on hypochromic disorders have been conducted in specialized health centers. The present study is aimed to describe the etiologies of hypochromic patches in dermatological area, in Bamako. We carried out a cross sectional study in the Dermatology Clinic of the "Centre National d'Appui à la lutte contre la Maladie (CNAM, Ex Institut Marchoux)". All acquired hypochromic patches (HP) were selected. HP was defined as a "skin patch lighter in pigmentation than normal surrounding skin with a diameter of at least 1 cm". The diagnosis was mainly based on clinical findings. The prevalence of HP was 3.42% and the main causes were seborrheic dermatitis (23.3%), pytiriasis alba (20.15%), vitiligo (18.9%), pityriasis versicolore (18.5%) and leprosy (12.6%). There are many causes of HP including leprosy, a disease though rare to date, but still prevalent in dermatological area.
    Le Mali médical 01/2012; 27(1):6-9.
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    ABSTRACT: Apart from a single report, the last publication of cutaneous leishmaniasis (CL) in Mali dates back more than 20 years. The absence of information on the current status of CL in Mali led us to conduct a cohort study in Kemena and Sougoula, two villages in Central Mali from which cases of CL have been recently diagnosed by Mali's reference dermatology center in Bamako. In May 2006, we determined the baseline prevalence of Leishmania infection in the two villages using the leishmanin skin test (LST). LST-negative individuals were then re-tested over two consecutive years to estimate the annual incidence of Leishmania infection. The prevalence of Leishmania infection was significantly higher in Kemena than in Sougoula (45.4% vs. 19.9%; OR: 3.36, CI: 2.66-4.18). The annual incidence of Leishmania infection was also significantly higher in Kemena (18.5% and 17% for 2007 and 2008, respectively) than in Sougoula (5.7% for both years). These data demonstrate that the risk of Leishmania infection was stable in both villages and confirm the initial observation of a significantly higher risk of infection in Kemena (OR: 3.78; CI: 2.45-6.18 in 2007; and OR: 3.36; CI: 1.95-5.8 in 2008; P<0.005). The absence of spatial clustering of LST-positive individuals in both villages indicated that transmission may be occurring anywhere within the villages. Although Kemena and Sougoula are only 5 km apart and share epidemiologic characteristics such as stable transmission and random distribution of LST-positive individuals, they differ markedly in the prevalence and annual incidence of Leishmania infection. Here we establish ongoing transmission of Leishmania in Kemena and Sougoula, Central Mali, and are currently investigating the underlying factors that may be responsible for the discrepant infection rates we observed between them. TRIAL REGISTRATION: ClinicalTrials.gov NCT00344084.
    PLoS Neglected Tropical Diseases 01/2009; 3(12):e565. · 4.57 Impact Factor
  • Annales De Dermatologie Et De Venereologie - ANN DERMATOL VENEREOL. 01/2007; 134(1):72-72.
  • Annales De Dermatologie Et De Venereologie - ANN DERMATOL VENEREOL. 01/2007; 134(1):36-37.
  • International Journal of Dermatology 11/2005; 44 Suppl 1:26-9. · 1.34 Impact Factor