Nicole L Griffin

Temple University, Philadelphia, Pennsylvania, United States

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Publications (9)24.73 Total impact

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    ABSTRACT: Humans stand alone from other primates in that we propel our bodies forward on a relatively stiff and arched foot and do so by employing an anatomical arrangement of bones and ligaments in the foot that can operate like a "windlass." This is a significant evolutionary innovation, but it is currently unknown when during hominin evolution this mechanism developed and within what genera or species it originated. The presence of recently discovered fossils along with novel research in the past two decades have improved our understanding of foot mechanics in humans and other apes, making it possible to consider this question more fully. Here we review the main elements thought to be involved in the production of an effective, modern human-like windlass mechanism. These elements are the triceps surae, plantar aponeurosis, medial longitudinal arch, and metatarsophalangeal joints. We discuss what is presently known about the evolution of these features and the challenges associated with identifying each of these specific components and/or their function in living and extinct primates for the purpose of predicting the presence of the windlass mechanism in our ancestors. In some cases we recommend alternative pathways for inferring foot mechanics and for testing the hypothesis that the windlass mechanism evolved to increase the speed and energetic efficiency of bipedal gait in hominins. Am J Phys Anthropol, 2014. © 2014 Wiley Periodicals, Inc.
    American Journal of Physical Anthropology 01/2015; 156(1). DOI:10.1002/ajpa.22636 · 2.38 Impact Factor
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    ABSTRACT: The modern human foot is a complex biomechanical structure that must act both as a shock absorber and as a propulsive strut during the stance phase of gait. Understanding the ways in which foot segments interact can illuminate the mechanics of foot function in healthy and pathological humans. It has been proposed that increased values of medial longitudinal arch deformation can limit metatarsophalangeal joint excursion via tension in the plantar aponeurosis. However, this model has not been tested directly in a dynamic setting. In this study, we tested the hypothesis that during the stance phase, subtalar pronation (stretching of the plantar aponeurosis and subsequent lowering of the medial longitudinal arch) will negatively affect the amount of first metatarsophalangeal joint excursion occurring at push-off. Vertical descent of the navicular (a proxy for subtalar pronation) and first metatarsophalangeal joint dorsal excursion were measured during steady locomotion over a flat substrate on a novel sample consisting of asymptomatic adult males and females, many of whom are habitually unshod. Least-squares regression analyses indicated that, contrary to the hypothesis, navicular drop did not explain a significant amount of variation in first metatarsophalangeal joint dorsal excursion. These results suggest that, in an asymptomatic subject, the plantar aponeurosis and the associated foot bones can function effectively within the normal range of subtalar pronation that takes place during walking gait. From a clinical standpoint, this study highlights the need for investigating the in vivo kinematic relationship between subtalar pronation and metatarsophalangeal joint dorsiflexion in symptomatic populations, and also the need to explore other factors that may affect the kinematics of asymptomatic feet.
    Journal of Anatomy 04/2013; DOI:10.1111/joa.12050 · 2.10 Impact Factor
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    ABSTRACT: The human metatarsophalangeal joints play a key role in weight transmission and propulsion during bipedal gait, but at present, the identification of when a habitual, human-like metatarsi-fulcrimating mechanism first appeared in the fossil record is debated. Part of this debate can be attributed to the absence of certain detailed quantitative data distinguishing human and great ape forefoot form and function. The aim of this study is to quantitatively test previous observations that human metatarsophalangeal joints exhibit greater amounts of dorsal excursion (i.e., dorsiflexion) than those of Pan at the terminal stance phase of terrestrial locomotion. Video recordings were made in order to measure sagittal excursions of the medial metatarsophalangeal joints in habitually shod/unshod adult humans and adult bonobos (Pan paniscus). Results indicate that the human first and second metatarsophalangeal joints usually dorsiflex more than those of bonobos. When timing of maximum excursion of the first metatarsophalangeal joint is coupled with existing plantar pressure data, the unique role of the human forefoot as a key site of leverage and weight transmission is highlighted. These results support hypotheses that significant joint functional differences between great apes and humans during gait underlie taxonomic distinctions in trabecular bone architecture of the forefoot.
    Journal of Human Evolution 12/2010; 59(6):608-19. DOI:10.1016/j.jhevol.2010.07.017 · 3.73 Impact Factor
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    ABSTRACT: The appearance of a forefoot push-off mechanism in the hominin lineage has been difficult to identify, partially because researchers disagree over the use of the external skeletal morphology to differentiate metatarsophalangeal joint functional differences in extant great apes and humans. In this study, we approach the problem by quantifying properties of internal bone architecture that may reflect different loading patterns in metatarsophalangeal joints in humans and great apes. High-resolution x-ray computed tomography data were collected for first and second metatarsal heads of Homo sapiens (n = 26), Pan paniscus (n = 17), Pan troglodytes (n = 19), Gorilla gorilla (n = 16), and Pongo pygmaeus (n = 20). Trabecular bone fabric structure was analyzed in three regions of each metatarsal head. While bone volume fraction did not significantly differentiate human and great ape trabecular bone structure, human metatarsal heads generally show significantly more anisotropic trabecular bone architectures, especially in the dorsal regions compared to the corresponding areas of the great ape metatarsal heads. The differences in anisotropy between humans and great apes support the hypothesis that trabecular architecture in the dorsal regions of the human metatarsals are indicative of a forefoot habitually used for propulsion during gait. This study provides a potential route for predicting forefoot function and gait in fossil hominins from metatarsal head trabecular bone architecture.
    Journal of Human Evolution 08/2010; 59(2):202-13. DOI:10.1016/j.jhevol.2010.06.006 · 3.73 Impact Factor
  • Nicole L Griffin · Brian G Richmond
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    ABSTRACT: Previous studies have referred to the degree of dorsal canting of the base of the proximal phalanx as an indicator of human-like metatarsophalangeal joint function and thus a diagnostic trait of habitual bipedality in the fossil record. Here, we used a simple method to investigate differences in forefoot function on a finer scale. Building on Duncan et al.'s (Am J Phys Anthropol 93 [1994] 67-81) research, we tested whether dorsal canting reflects differences between sexes in locomotor behavior, whether habitual shoe wear influences dorsal canting in humans, and whether proximal joint morphology differs between rays in Pan and humans. Our results corroborate previous research in showing that humans have proximal phalanges with joint orientations that are significantly more dorsal than, but overlap with, those of great apes. We also found that male gorillas have significantly more dorsally canted second proximal phalanges than their female counterparts, while the opposite pattern between the sexes was found in Pan troglodytes. Inter-ray comparisons indicate that Pan have more dorsally canted first proximal phalanges than second proximal phalanges, while the opposite pattern was found in humans. Minimally shod humans have slightly but significantly more dorsally canted second proximal phalanges than those of habitually shod humans, indicating that phalanges of unshod humans provide the most appropriate comparative samples for analyses of early hominins. Overall, our analysis suggests that though the measurement of dorsal canting is limited in its sensitivity to certain intraspecific differences in function, phalangeal joint orientation reflects interspecific differences in joint function, with the caveat that different patterns of forefoot function during gait can involve similar articular sets of metatarsophalangeal joints.
    American Journal of Physical Anthropology 01/2009; 141(1):116-23. DOI:10.1002/ajpa.21121 · 2.38 Impact Factor
  • Roshna E. Wunderlich · Nicole L. Griffin · Allen B. Wickham
    Clinical Biomechanics 06/2008; 23(5):705-706. DOI:10.1016/j.clinbiomech.2008.03.050 · 1.97 Impact Factor
  • Nicole L Griffin
    Journal of Human Evolution 02/2008; 54(1):162-8. DOI:10.1016/j.jhevol.2007.09.008 · 3.73 Impact Factor
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    N L Griffin · A D Gordon · B G Richmond · S C Antón
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    ABSTRACT: This study describes a human foot bone assemblage from prehistoric Mangaia, Cook Islands in the context of diaphyseal cross-sectional strength measures. We use this sample to test the hypothesis that habitually unshod individuals who walk over rugged terrain will have stronger foot bones than a sample of habitually shod industrialized people. Specifically, we examine whether the Mangaian sample has a stronger size-adjusted metatarsal (MT) and phalangeal cross-sectional properties than the industrial sample, drawn from the Terry Collection. Contrary to expectations, residual analyses showed that most values of cross-sectional area (CA) and torsional resistance (J) of MTs 1-4 and the hallucal proximal phalanx (HPP) of the Mangaians are among those in the lower range of the Terry Collection sample. However, the bending strength ratios (Zy/Zx) of the Mangaian HPP are significantly greater than those of the Terry Collection. While characteristics such as forefoot shape variation between the sexes and among geographic populations cannot be ruled out as influential factors, cross-sectional properties of the hallucal proximal phalanges, but not the MTs, indicate terrain complexity in prehistoric populations.
    HOMO - Journal of Comparative Human Biology 02/2008; 59(1):27-40. DOI:10.1016/j.jchb.2006.08.008 · 0.73 Impact Factor
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    Nicole L Griffin · Brian G Richmond
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    ABSTRACT: The human forefoot presents an interesting biomechanical problem of clinical importance because loads are distributed unequally across multiple bones. The fact that long bones typically have a several-fold safety factor relative to peak loads suggests that metatarsal strengths should be related to their peak loads. This study is the first to systematically examine the cross-sectional geometric properties of the human forefoot and their relationship to external loads during walking and running. We report midlength cross-sectional geometric properties (CA, Ix, Iy, Imax, Imin, J, Zx, and Zy) of metatarsals (1-5) and the hallucial proximal phalanx of a shod industrial population (n = 40) obtained using computed tomography. We then examine the relationship between these measures of shaft strength and published plantar pressure data sets recorded during the following functional activities: standing, at the push-off stage of the walking cycle, the full walking cycle, and running. Cross-sectional geometric properties of the first ray are greater than those of other rays, even when scaled to bone length. This pattern corresponds to the high pressures recorded for the first ray during most activities. The relationships between cross-sectional geometric properties of the lateral metatarsals and peak plantar pressure data are more complex. Metatarsals 2-4 are weakest in most cross-sectional geometric properties. However, metatarsal 2, and to a lesser extent metatarsal 3, experience relatively high peak pressures. On average, geometric measures of axial and bending strengths (adjusted relative to body size) are lower in females than males, and in European Americans than in African Americans, which corresponds to the respective rates of general metatarsal stress fracture in these groups. The discrepancy between strength and plantar pressure values in metatarsals 2 and 3 is consistent with the high incidence of stress fractures in these bones and underscores the importance of soft tissues, such as the plantar fascia and flexor musculature, in moderating metatarsal shaft strain.
    Bone 09/2005; 37(2):253-60. DOI:10.1016/j.bone.2005.04.019 · 3.97 Impact Factor

Publication Stats

92 Citations
24.73 Total Impact Points


  • 2013–2015
    • Temple University
      • Department of Anatomy and Cell Biology
      Philadelphia, Pennsylvania, United States
  • 2010
    • Duke University
      • Department of Evolutionary Anthropology
      Durham, North Carolina, United States
  • 2005–2009
    • George Washington University
      • Center for the Advanced Study of Hominid Paleobiology
      Washington, Washington, D.C., United States