Mitesh Patel

Publications (4)29.83 Total impact

• Article: Catalysis of stannane-mediated radical chain reactions by benzeneselenol.

  David Crich, Daniel Grant, Venkataramanan Krishnamurthy, Mitesh Patel
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  ABSTRACT: The discovery and development of the catalysis of stannane-mediated radical chain reactions by benzeneselenol, generated in situ by reduction of diphenyl diselenide with tributyltin hydride, are described. The catalytic sequence is discussed in terms of polarity reversal catalysis of radical chain reactions, and applications to synthesis are presented. These include the prevention of numerous radical rearrangement reactions, the ability to intervene in certain multistep radical rearrangements, especially aryl and vinyl radical cyclizations, at intermediate stages with advantages to the product profile, and the effective trapping of allyl-, benzyl-, and cyclohexadienyl-type radicals, permitting inter alia the isolation of aryl cyclohexadienes and their application in synthesis.
  Accounts of Chemical Research 07/2007; 40(6):453-63. · 21.64 Impact Factor
• Article: On the nitrile effect in L-rhamnopyranosylation.

  David Crich, Mitesh Patel
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  ABSTRACT: It is shown that the use of 5% acetonitrile or propionitrile in dichloromethane functions to increase the beta-selectivity of a number of L-rhamnopyranosylation reactions conducted by the thioglycoside method with activation by the 1-benzenesulfinyl piperidine/trifluoromethanesulfonic anhydride couple. The use of more significant quantities of acetonitrile or propionitrile results in the formation of complex reaction mixtures containing little coupled product, but from which Ritter-type products can be isolated.
  Carbohydrate Research 08/2006; 341(10):1467-75. · 2.33 Impact Factor
• Article: Facile dearomatizing radical arylation of furan and thiophene.

  David Crich, Mitesh Patel
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  ABSTRACT: In the presence of catalytic diphenyl diselenide, reduced in situ to benzeneselenol, tributyltin hydride and V-70 promote the addition of aryl iodides to furan and thiophene. The adduct radicals are trapped by the selenol to give the 2-aryl-2,3-dihydro and 2-aryl-2,5-dihydro heterocyclic products. When the iodide is an o-iodophenol, a cyclization follows the radical addition and provides bridged bicyclic acetals. [reaction: see text]
  Organic Letters 09/2005; 7(17):3625-8. · 5.86 Impact Factor
• Article: Direct Synthesis of Heterobiaryls by Radical Addition to Pyridine: Expeditious Synthesis of Chelating Ligands.

  David Crich, Mitesh Patel
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  ABSTRACT: For Abstract see ChemInform Abstract in Full Text.
  ChemInform 05/2005; 36(25).