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J. Inf. Sci. Eng. 01/2011; 27:761-775.
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Information Quality in e-Health - 7th Conference of the Workgroup Human-Computer Interaction and Usability Engineering of the Austrian Computer Society, USAB 2011, Graz, Austria, November 25-26, 2011. Proceedings; 01/2011
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Comput. Sci. Inf. Syst. 01/2011; 8:73-100.
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01/2010
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ABSTRACT: Quartz crystal microbalance (QCM) and atomic force microscope (AFM) were utilized to investigate the anticoagulant activities of sulfonated polymers against fibrin formation. Quantitative data on the thickness and viscoelastic properties of coagulated fibrin layers formed at various concentrations of sulfonated polymers were obtained from QCM results by applying a Voight-based model. Four types of sulfonated polymers including sulfonated chitosan (S-chitosan), monosulfonated poly(ethylene oxide) (PEO-SO(3)), disulfonated PEO (PEO-2SO(3)), and 4-arm sulfonated PEO (PEO-4SO(3)) were studied to compare with heparin in the presence or in the absence of antithrombin III (AT). All the sulfonated polymers showed the heparin-like activities to inhibit the function of thrombin for fibrin formation in the more or less extent while chitosan and PEO did not. Especially, S-chitosan prepared by sulfonation with propane sultone under a mild condition exhibited 35% of activity of free heparin while sulfonated PEOs showed 5-12% of heparin. However, there was no effect of S-chitosan without AT, indicating that the S-chitosan interfered in the fibrin formation process mainly by AT-mediated inhibition against thrombin. The sulfonated polymers not only decreased the coagulated mass but also affected the surface architecture and viscoelastic properties of the final fibrin layers coagulated. With increasing the concentrations of heparin or heparin-like polymers, the thick and textured fibrin layer was gradually diminished to reveal the thin and rigid fibrinogen-adsorbed layer, and therefore the fibrin layer became more rigid. The surface architecture of fibrin layers was confirmed by AFM. With increasing anticoagulants the density of both fibrin fiber and junctions between fibers was decreased but the fiber diameter was not much reduced.
Langmuir 06/2009; 25(12):7032-41. · 4.19 Impact Factor
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ABSTRACT: Viscoelastic property and morphology of fibrin, which is caused by the enzymatic action of thrombin on fibrinogen, was studied quantitatively as a function of antithrombin III (AT) and heparin concentration by adding fibrinogen, heparin, AT, and thrombin, sequentially. A quartz crystal microbalance with impedance analysis (QCM-Z) was used to detect the change of viscoelastic properties as well as the thickness of adsorbed layer during fibrin formation process, while AFM was used to characterize the surface morphology of fibrin layer under the influence of two known anticoagulants. By the addition of fibrinogen initially, a rigid and thin fibrinogen layer with rather smooth surface morphology was formed on the substrate. Then, the addition of thrombin in the absence of AT and heparin, resulted in viscous and thick fibrin gel with textured surface morphology. As an anticoagulant, AT was added before the injection of thrombin, but AT in the absence of heparin showed only marginal effects at higher concentration of AT than that of thrombin. On the contrary, the thick and viscous fibrin layer was altered gradually to more fibrinogen-like layer as the heparin concentration increases at low concentrations of AT, demonstrating the powerful anticoagulant effect by heparin/AT complex. Interestingly, heparin alone without AT was also effective in preventing fibrin formation, influencing the viscoelastic property and morphology of fibrin.
Colloids and surfaces. B, Biointerfaces 11/2008; 68(1):111-9. · 2.60 Impact Factor
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ABSTRACT: In this paper, we present a system that takes an input document and searches semantically-related documents on the Web. Relatedness is measured based on two criteria. One is to check whether some representative words inside the input document appear in candidate documents. The other is to check whether words that describe the contextual information about the input document appear in candidate documents.
Semantic Computing and Applications, 2008. IWSCA '08. IEEE International Workshop on; 08/2008
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MoMM'2008 - The 6th International Conference on Advances in Mobile Computing and Multimedia, 24 - 26 November 2008, Linz, Austria; 01/2008
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ABSTRACT: Object-oriented concepts are difficult to learn. In this paper, we propose a music programming language that involves music in object-oriented programming. We also present a client-server based system for individual learning and a P2P-based system for collaborative learning in a JXTA network.
Advanced Learning Technologies, 2007. ICALT 2007. Seventh IEEE International Conference on; 08/2007
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ABSTRACT: In this paper, we present an adaptive mobile learning system that helps users study learning materials anytime anywhere with handheld computers such as PDAs. The theme of this research is to demonstrate the synergetic effects of mobility and adaptivity that are contextualized in a learning environment. Our system considers the information about the cognitive load that a learner is experiencing and learning contents are adaptively presented based on the cognitive and competency attributes of learners. We experimented our system against elementary school students and the results indicated that not only mobility made it possible for learners to study learning materials conveniently, but adaptively providing contents to users based on their cognitive traits enhanced the learning process greatly
Advanced Information Networking and Applications, 2006. AINA 2006. 20th International Conference on; 05/2006
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Information Systems Technology and its Applications, 5th International Conference ISTA'2006, May 30-31, 2006, Klagenfurt, Austria; 01/2006
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ABSTRACT: The development of mobile devices and wireless networks made it possible for users to seamlessly use different devices to
recognize changes in their computing environment. In this paper, we propose a music information retrieval system (MIRS) that
exploits various types of contextual information. Our system is based on JXTA technology which enables to join at any time
and direct communication between peers. It supports the personalized retrieval of music information at specific moments and
locations. Each peer can run a context interpreter and each edge peer functions as a query requester or a query responser.
The query requester’s context interpreter analyzes user’s context and customizes the search result. The query responser’s
context interpreter analyzes the pattern for the query melody and selects requested music information.
10/2005: pages 211-214;
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ABSTRACT: In this paper, we present an adaptive learning tool that can help students learn the concepts of automata theory. It is an extension of an existing software called NEO_VAM (Lee and Park, 2005) which was originally developed for helping students understand the concepts of automata. The extensions were made in order to provide students who have different backgrounds with appropriate contents by utilizing AHA! (De Bra et al., 2003) which is an open source adaptive hypermedia system. With the learning tool, students can experiment constructing a simple computer and test transition functions based on user's knowledge level. Different types of adaptations are employed in order to provide appropriate contents to users.
Advanced Learning Technologies, 2005. ICALT 2005. Fifth IEEE International Conference on; 08/2005
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Lernen, Wissensentdeckung und Adaptivität (LWA) 2005, GI Workshops, Saarbrücken, October 10th-12th, 2005; 01/2005
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Lernen, Wissensentdeckung und Adaptivität (LWA) 2005, GI Workshops, Saarbrücken, October 10th-12th, 2005; 01/2005
