Luis Duque

Instituto Valenciano de Infertilidad IVI, Valenza, Valencia, Spain

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Publications (3)3.97 Total impact

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    ABSTRACT: To evaluate the impact of aromatase inhibitors as adjuvant treatment in IVF cycles on intraovarian androgens and cycle outcome. Observational, pilot study. University-affiliated IVF unit. One hundred forty-seven low responder patients with a previous canceled IVF cycle; 71 patients were treated with letrozole 2.5 mg plus a high-dose FSH/hMG-antagonist regimen, and 76 patients were similarly treated but letrozole was not employed. In vitro fertilization treatment with an antagonist FSH/hMG protocol with or without letrozole was administered during the first 5 days of stimulation; hormones were evaluated in both serum and follicular fluid. Number of oocytes retrieved, fertilization rate, implantation rate, and pregnancy rate; androstenedione, T, E2, and P values in serum and follicular fluid. Letrozole-treated patients showed significantly higher levels of follicular fluid T and androstenedione (80.3 vs. 43.8 pg/mL and 57.9 vs. 37.4 mg/mL, respectively). Similarly, these patients had a higher number of oocytes retrieved (6.1 vs. 4.3) and a higher implantation rate (25% vs. 9.4%) despite similar doses of FSH/hMG (3,627 vs. 3,804 IU). Adding 2.5 mg of letrozole to a high-dose FSH/hMG antagonist protocol increases intraovarian androstenedione and T concentration and improves IVF cycle outcome in poor responder patients.
    Fertility and sterility 08/2005; 84(1):82-7. · 3.97 Impact Factor
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    ABSTRACT: Puntos clave 89 La dificultad para tener hijos afecta al 15% de las parejas en edad fértil. La inseminación artificial consigue resultados satisfactorios en la mitad de las parejas que consultan. La fecundación in vitro y la inyección intracitoplásmica de espermatozoides (ICSI) pueden resolver problemas muy graves de fertilidad, sin aumentar el número de anomalías congénitas en los recién nacidos, aunque los hijos pueden heredar la anomalía del padre que le producía la infertilidad. La donación de óvulos es una opción atractiva cuando no se producen ovocitos o éstos son de mala calidad, y es exitosa en más del 95% de las parejas en 3 o 4 ciclos. El diagnóstico preimplantatorio permite la selección de embriones para evitar la transmisión de enfermedades genéticas o cromosómicas.
    An Pediatr Contin. 01/2005; 3:199-204.
  • Fertility and Sterility - FERT STERIL. 01/2004; 82.