Lee A Funk

Publications (1)2.55 Total impact

• Article: Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid.

  Jeffrey A Pfefferkorn, Richard Nugent, Rebecca J Gross, Meredith Greene, Mark A Mitchell, Matthew T Reding, Lee A Funk, Rebecca Anderson, Peter A Wells, John A Shelly, Robert Anstadt, Barry C Finzel, Melissa S Harris, Robert E Kilkuskie, Laurice A Kopta, Francis J Schwende
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  ABSTRACT: A novel series of non-nucleoside HCV NS5B polymerase inhibitors was prepared from a (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid template. Solution and solid phase analog synthesis focused on the northern region of the template combined with structure based design led to the discovery of several potent and orally bioavailable lead compounds.
  Bioorganic & Medicinal Chemistry Letters 07/2005; 15(11):2812-8. · 2.55 Impact Factor