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ABSTRACT: Novel, simplified analogues of the microtubule-stabilizing anticancer agent laulimalide, including the first derivatives with unnatural side chains, were designed by molecular modelling, synthesized by a late-stage diversification strategy, and evaluated in vitro for growth inhibition of human ovarian carcinoma cell lines (A2780, A2780/AD10).
Bioorganic & Medicinal Chemistry Letters 06/2005; 15(9):2243-7. · 2.34 Impact Factor