Publications (22)18.08 Total impact
-
Article: [Real-time three-dimensional echocardiographic assessment of left ventricular diastolic dyssynchrony and dysfunction in hypertrophic cardiomyopathy].
[show abstract] [hide abstract]
ABSTRACT: To assess left ventricular (LV) regional diastolic function in patients with hypertrophic cardiomyopathy (HCM) using single-beat real-time three-dimensional echocardiography (RT-3DE). Sixty-nine patients with HCM (LV ejection fraction≥45%) and 50 normal control subjects underwent examinations by two-dimensional echocardiography (2DE) and RT-3DE. The parameters analyzed by RT-3DE included the end diastolic sphericity index (EDSI), diastolic dyssynchrony index (DDI), dispersion end diastole [DISPED, including late (DDI-late) and early (DDI-early) diastole, dispersion end diastole (DISPED-late), and dispersion early diastole (DISPED-early)]. The patients were divided into 3 groups with impaired relaxation (n=23), pseudonormal filling (n=37), and restrictive filling (n=9). DDI and DISPED increased with the severity of diastolic dysfunction. In end diastole, DDI-late and DISPED-late were abnormal in cases with severe diastolic dysfunction (7.95∓2.75 and 26.76∓17.19, respectively, P<0.0001) but normal in cases with mild diastolic dysfunction. In early diastole, DDI-early and DISPED-early both increased in cases of mild (8.57∓2.24 and 25.44∓6.31, respectively, P<0.0001) and moderate (9.56∓4.66 and 35.42∓14.19, respectively, P<0.0001) diastolic dysfunction. In patients with HCM, dyssynchrony in early diastole is more obvious than that in late diastole and shows also a stronger correlation with diastolic dysfunction. This preclinical lesion can be detected by single-beat RT-3DE.Nan fang yi ke da xue xue bao = Journal of Southern Medical University 01/2013; 33(1):8-12. -
Article: [Echocardiographic study of double mutations of myosin-binding protein C3 gene in Chinese patients with familial hypertrophic cardiomyopathy].
[show abstract] [hide abstract]
ABSTRACT: Objective: To determine the associated mutations in myosin-binding protein C3 (MYBPC3) in Chinese patients with family hypertrophic cardiomyopathy (FHCM) and to analyze the genotype and phenotype correlation. Methods: One family with 27 family members affected with FHCM was chosen for the study. The full encoding exons of MYBPC3 were amplified with PCR and the products were sequenced. The clinical data and echocardiography were collected. Results: Two missense mutations in the family were identified: one was C.2526C>G mutation which caused a tyrosine (Tyr) to terminator exchange at amino acid residue 842 and the other was C.2971G>A mutation which resulted in a valine (Val) to methionine (Met) exchange at amino acid residue 991. Four patients in the family suffered from HCM with asymmetric interventricular septal hypertrophy. The left ventricular diastolic function was significantly reduced. Signs of regional diastolic abnormalities occurred in some mutation carriers. Conclusion: Severe hypertrophy and diastolic dysfunction of the disease are compatible with the presence of double mutations in MYBPC3. Signs of regional diastolic abnormalities suggest a primary response to the mutations of MYBPC3 expression.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 01/2013; 38(1):14-9. -
Article: [Preliminary study of real-time three-dimensional dobutamine stress echocardiography for coronary artery disease assessment].
[show abstract] [hide abstract]
ABSTRACT: To evaluate the efficacy and safety of real-time three-dimensional dobutamine stress echocardiography for coronary artery disease assessment. A total of 14 patients suspected of coronary artery disease (CAD) underwent real-time three-dimensional dobutamine stress echocardiography. The initial infusion rate of dobutamine was 5 µg×kg(-1) ×min(-1), followed by 10 µg×kg(-1)×min(-1) and peak infusion 20 µg×kg(-1)×min(-1) in 3 min stages. At baseline state, stress stages and after the study, the real-time three-dimensional (RT3D) images were captured and assessed by wall motion score index (WMSI) and regional ejection fraction (rEF). And the parameters of these two modalities versus coronary angiography (CAG) were compared and analyzed. Adverse reactions were also observed. All patients completed the stress study uneventfully. As compared with CAG, these two modalities showed no significant difference (P > 0.05) and satisfactory agreement (κ values of 0.704 and 0.759 respectively). The diagnostic parameters of these modalities were: sensitivity (78% vs 89%), specificity (92% vs 88%), positive predictive value (PPV) (88% vs 84%), negative predictive value (NPV) (85% vs 91%) and overall accuracy (86% vs 88%). Real-time three-dimensional dobutamine stress echocardiography is an effective, rapid and safe technique of assessing coronary artery disease. It is worthy of wider clinical applications.Zhonghua yi xue za zhi 10/2012; 92(39):2747-51. -
Article: An initial study on left ventricular diastolic function in patients with hypertrophy cardiomyopathy using single-beat, real-time, three-dimensional echocardiography.
[show abstract] [hide abstract]
ABSTRACT: To assess the regional diastolic function in patients with hypertrophic cardiomyopathy (HCM) by using single-beat, real-time, three-dimensional echocardiography (RT-3DE). Sixty-five patients with HCM in sinus rhythm together with fifty age- and gender-matched normal controls were studied by two dimensional echocardiography (2DE) and RT-3DE. The parameters analyzed by RT-3DE included: left ventricular (LV) volumes, left ventricular ejection fraction (LVEF), end diastolic sphericity index (EDSI), diastolic dyssynchrony index (DDI), dispersion end diastole (DISPED), and normalized 17 segmental volume-time curves. Evaluated by RT-3DE, LVEF was slightly lower compared with 2DE (63.2 ± 6.8% vs. 59.1 ± 6.4%, P < 0.0001). Normal subjects had relatively uniform volumetric curves for all LV segments. In HCM patients, the segmental volumetric curves were dyssynchronous. Increased DDI and DISPED in end diastole were observed in patients with HCM (9.95 ± 3.75, 41.76 ± 17.19, P < 0.0001), and not all abnormal volumetric segments occurred in the hypertrophic regions. Patients with HCM have presented regional diastolic dyssynchrony in the diastole phase, and this preclinical lesion can be recognized by single-beat RT-3DE.Journal of Geriatric Cardiology 09/2012; 9(3):220-7. -
Article: [Assessment of the right ventricular function in healthy volunteers with one beat full-volume real-time three-dimensional echocardiography.]
[show abstract] [hide abstract]
ABSTRACT: OBJECTIVE: To determine the normal value of right ventricle using one beat full-volume real-time three-dimensional echocardiography (RT-3DE) and assess the feasibility of this technique. METHODS: One beat full volume images were acquired at the apical 4 chamber view in 129 healthy volunteers. The right and left ventricular volumes were examined with the eSie LVA and RVA. The subjects were divided into 2 gender groups (male and female) and 3 age groups (20 - 39 years old, 40 - 59 years old, 60 years old and above). RESULTS: Adequate data were obtained in 129 subjects. The RV-EDV was (92.4 ± 21.3) ml, RV-ESV (34.6 ± 9.2) ml, RV-SV (57.8 ± 13.9) ml, RV-EF (62.5 ± 5.0) ml. EDV, ESV, and EF were significant different while SV was similar between RV and LV (all P < 0.05). RV-EDV (r = 0.517, P = 0.001), RV-ESV (r = 0.588, P = 0.001) and RV-SV(r = 0.409, P = 0.001) were correlated well with BSA. RV-EDV, RV-ESV and RV-SV were significantly higher in males than in females (all P < 0.001). RV-EDV, RV-SV and RV-EF decreased with aging (P < 0.05). CONCLUSIONS: Right ventricle function can be measured noninvasively by RT-3DE with high feasibility. This novel method contributes to the detailed study of right heart function in various cardiovascular diseases.Zhonghua xin xue guan bing za zhi [Chinese journal of cardiovascular diseases] 08/2012; 40(8):702-705. -
Article: [Evaluation of carotid artery plaque stability with ¹⁸F-FDG PET/CT and contrast-enhanced ultrasonography].
[show abstract] [hide abstract]
ABSTRACT: To assess the value of contrast-enhanced ultrasonography (CEUS) and fluorodeoxyglucose positron emission tomography-computed tomography (¹⁸F-FDG PET/CT) in evaluating the stability of carotid atherosclerosis. Seventeen patients with 21 carotid artery plaques received examinations with CEUS. According to the nature of the plaques, the patients were divided into soft and mixed plaque group and hard and calcified plaque group. The maximal enhancement intensity of the plaques (I(MAX)) and maximal plaque density (D(MAX)) were measured to quantify the neovasculature. The patients also underwent concurrent ¹⁸F-FDG PET/CT, and ¹⁸F-FDG uptake was quantified by the mean standard uptake values (SUV(mean)), an index reflecting the inflammatory activity in the plaque. The findings in CEUS and PET/CT were comparatively analyzed for these cases. The D(MAX) of the plaque in soft and mixed plaque group was significantly greater than that in hard and calcified plaque group (4.26±3.65 vs 1.41±1.47, P<0.05); the I(MAX) was also greater in the former group, but this difference was not statistically significant (26.83±19.61 vs 24.73±29.85, P=0.869). The soft and mixed plaques tended to have higher SUVmean than the hard and calcified plaques (1.70±0.45 vs 1.47±0.12, P=0.099). The values of I(MAX) and D(MAX) were not found to correlate to SUV(mean) in these patients. CEUS can sensitively show the status of neovascularization within the carotid atherosclerosis plaques, and PET/CT reflects the inflammatory activity in the plaques. The combination of these two imaging modalities allows the evaluation of plaque stability in terms of neoangiogenesis and inflammatory activity.Nan fang yi ke da xue xue bao = Journal of Southern Medical University 07/2012; 32(7):981-5. -
Article: [Quantification of left and right ventricular systolic function in patients with dilated cardiomyopathy using real-time three-dimensional echocardiography].
[show abstract] [hide abstract]
ABSTRACT: To assess left and right ventricular systolic function in patients with dilated cardiomyopathy (DCM) using real-time three-dimensional echocardiography (RT-3DE). Fifty DCM patients and 50 normal subjects were enrolled. Left and right ventricular systolic function parameters including end-systolic volume (ESV) and end-diastolic volume (EDV), stroke volume (SV) and ejection fraction (EF) were measured with RT-3DE. The systolicdyssynchrony index (SDI) for left ventricular systolic function was also measured in the same time. The study compared the data of the left and right ventricular systolic function parameters between the DCM group and the control group. Cardiac magnetic resonance (CMRI) was performed in a subgroup of the 30 DCM patients to confirm RT-3DE measurements. The results of EDV, ESV and SDI measured by RT-3DE were significantly higher in patient group with DCM than those in the control group (P<0.001). The result of EF was significantly lower in patients with DCM than in normal subjects (P<0.001), but SV showed no significant difference between the two groups (P>0.05). In the DCM group, the results showed a significantly negative correlation between left ventricular ejection fraction (LVEF) and SDI (r=-0.697, P<0.001), and there was also a moderate correlation between LVEF and right ventricular ejection fraction (RVEF) (r=0.496, P<0.01). The results of ESV, EDV and EF showed no significant differences as measured by RT-3DE or CMRI in the patient group (P>0.05), and there was also good correlation between the two measurements (LVEF: r=0.89, P<0.01; RVEF: r=0.85, P<0.01). Left and right ventricular systolic function in DCM could be evaluated by RT-3DE with left and right ventricular systolic function parameters.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 06/2012; 37(6):561-6. -
Article: Estimation of coronary artery stenosis by low-dose adenosine stress real-time myocardial contrast echocardiography: a quantitative study.
[show abstract] [hide abstract]
ABSTRACT: Coronary microcirculation reserve is an important field in the research of coronary artery disease, but it is difficult to identify clinically. Currently it is widely accepted that myocardial contrast echocardiography (MCE) is a safe, inexpensive method and has comparatively high image resolution. The present study used quantitative low-dose adenosine stress real-time (RT)-MCE to estimate myocardial perfusion and the coronary stenosis. Forty-nine left ventricular (LV) segments from 14 unselected patients were divided into three groups according to the coronary angiography or CT angiography results: group 1 (n = 20, 41%) without significant stenosis (< 70%), group 2 (n = 12, 24%) with successful percutaneous coronary intervention (PCI), and group 3 (n = 17, 35%) with significant stenosis (> 70%). RT-MCE was performed in these patients with low-dose adenosine stress and continuous infusion of Sonovue. The replenishing curves were drawn according to the contrast density measured at the end-diastolic frame of every cardiac circle by ACQ software. Forty-nine LV segments with satisfactory image quality were picked for quantitative contrast echo analysis. The replenishing curves were analyzed at baseline and after stress. Perfusion of group 3 did not decrease significantly at baseline, and showed no improvement during adenosine stress and was significantly different from groups 1 and 2 (P < 0.05). The A·β and β increased more significantly in group 1 than in groups 2 and 3 (P < 0.05). In a receiver operating characteristic (ROC) curve analysis, A·β under adenosine stress < 1.74 dB/s had a sensitivity and specificity of 71% for diagnosis of coronary artery stenosis, reduced adenosine-induced rise (percentage of A·β < 81%) had a sensitivity and specificity of 83% and 79% for the diagnosis of low-reserve, and β < 54% had a sensitivity of 86% and specificity of 79%. Rest perfusion of severely stenosed arteries may be normal, but adenosine stress can detect the impaired perfusion reserve. Low-dose adenosine stress RT-MCE provides good accuracy for the evaluation of coronary perfusion reserve and hence coronary stenosis.Chinese medical journal 05/2012; 125(10):1795-8. · 0.86 Impact Factor -
Article: [Quantitative characterization of vortex flow in patients with early myocardial ischemia by echocardiography using vector flow mapping].
[show abstract] [hide abstract]
ABSTRACT: To quantitatively characterize vortex flow in patients with early myocardial ischemia by echocardiography using vector flow mapping (VFM) and explore a new diagnostic index of early myocardial ischemia. This study was conducted among 105 patients with suspected angina pectoris, who were free of a previous cardiac history with a normal ejection fraction. Patients without significant coronary artery stenoses constituted the control group (n=49) and those with significant coronary artery stenoses (n=56) constituted the early myocardial ischemia group. All the patients underwent conventional ultrasonic inspection and VFM. The velocity vector and vorticity were estimated by VFM. The vortex parameters including vortex flow, radius, diameter, area and vortex relative strength index were measured. No significant differences were found in the vortex parameters including the vortex flow, radius, diameter or area between the two groups (P>0.05), but vortex relative strength index was significantly lower in early myocardial ischemia group (23.68∓11.66 vs 20.20∓6.29, P<0.05). VFM is feasible for quantitative evaluation of left ventricular vorticity in healthy individuals and patients with early myocardial ischemia, and the vortex relative strength index may serve as a novel index for the diagnosis of early myocardial ischemia.Nan fang yi ke da xue xue bao = Journal of Southern Medical University 04/2012; 32(4):492-5. -
Article: Subclinical left ventricular dysfunction revealed by circumferential 2D strain imaging in patients with coronary artery disease and fragmented QRS complex.
[show abstract] [hide abstract]
ABSTRACT: Fragmented QRS (fQRS) complexes on a routine 12-lead electrocardiogram were associated with adverse cardiac events, including sudden death in patients with coronary artery disease (CAD). To investigate the relationship between the fQRS complex and global and regional left ventricular (LV) functions in patients with CAD. The study consisted of 176 patients (68 ± 9 years; 145 [82%] men) with CAD with narrow QRS duration and preserved LV ejection fraction (>45%). All patients underwent detailed 2-dimensional speckle-tracking echocardiography to determine global and segmental (basal, middle, and apical) LV strains and strain rates and were prospectively followed-up in the outpatient clinic. Fifty-five patients (31%) had fQRS complexes. Global, middle, and apical LV longitudinal, radial, and circumferential strains and strain rates were significantly lower in the fQRS group than in the non-fQRS group (all P <.05). Multivariate logistic regression analysis revealed that the fQRS complex was associated with decreased global circumferential strain (odds ratio 1.19; 95% confidence interval 1.06-1.33; P = .003) and multivessel disease (odds ratio 3.69; 95% confidence interval 1.35-10.08; P = .011). Kaplan-Meier analysis revealed that event-free survival for cardiac events was significantly lower in the fQRS group than in the non-fQRS group (P = .036). Our results demonstrated that the fQRS complex in patients with CAD with preserved LV ejection fraction was associated with subclinical global and regional LV dysfunctions as detected by 2-dimensional speckle-tracking imaging, and the results also predicted adverse cardiac events.Heart rhythm: the official journal of the Heart Rhythm Society 01/2012; 9(6):928-35. · 4.56 Impact Factor -
Article: Beneficial effect of adenosine on myocardial perfusion in patients treated with primary percutaneous coronary intervention for acute myocardial infarction.
[show abstract] [hide abstract]
ABSTRACT: The present study investigated the effects of intravenous adenosine on myocardial perfusion and segmental contractile function when used as an adjunct of primary percutaneous coronary intervention (PCI) in patients with acute ST segment elevation myocardial infarction (STEMI). Patients were randomly assigned to receive intravenous adenosine (n = 35) or saline (n = 34) within 12 h of STEMI. Myocardial contrast echocardiography (MCE) and velocity vector imaging (VVI) were performed 7 days after primary PCI. Serial echocardiography was performed on Days 7 and 30. Capillary blood volume (A; 6.34 ± 1.98 vs 5.64 ± 1.84 dB; P = 0.03) and myocardial blood velocity (β; 0.13 ± 0.04 vs 0.1 ± 0.04/s; P = 0.01) were higher in the adenosine group than in control patients. Myocardial blood flow (A × β) was 0.82 ± 0.37 dB/s with adenosine compared with 0.57 ± 0.4 dB/s in control patients (P < 0.01). Improvements were seen in the adenosine compared with the control group in terms of myocardial wall strain(-13.52 ± 5.61% vs -11.47 ± 5.25%, respectively; P = 0.03), strain rate (-1.08 ± 0.52 vs -0.90 ± 0.44/s, respectively; P = 0.03) and segmental ejection fraction (53.66 ± 12.04% vs 48.40 ± 14.99%, respectively; P = 0.03). There was a correlation between myocardial perfusion in apical anterior segments, peak systolic strain (P = 0.001), strain rate (P = 0.001) and segmental ejection (P < 0.001). Global contractile function was better in the adenosine-treated than control group. At the 1 month follow up, there were no significant differences between groups in terms of the incidence of recurrent angina or heart failure. The results of the present study suggest that periprocedural intravenous adenosine contributes to improvements in myocardial perfusion, segmental wall motion and global contractile function in patients with acute myocardial infarction undergoing primary PCI.Clinical and Experimental Pharmacology and Physiology 01/2012; 39(3):247-52. · 1.85 Impact Factor -
Article: Relationship between ventricular dyssynchrony and T-wave alternans in patients with coronary artery disease.
[show abstract] [hide abstract]
ABSTRACT: Coronary artery disease (CAD) is associated with increased dispersion of repolarization and sudden cardiac death. We sought to investigate whether ventricular dyssynchrony is associated with proarrhythmic repolarization dispersion as measured by T-wave alternans (TWA) in patients with CAD. We evaluated 154 patients (67 ± 9 years, 123 men) with documented CAD, who underwent exercise treadmill testing and echocardiographic examination. TWA was analyzed continuously during treadmill testing in all standard precordial leads by time-domain method. Tissue Doppler imaging was performed to measure inter- and intraventricular dyssynchrony. Increased TWA ≥ 60μV was observed in 42 (27%) patients. There was higher prevalence of females (31 vs 16%, P = 0.04) and greater body mass index (25.7 ± 2.6 vs 24.6 ± 3.0 kg/m², P = 0.04) in the TWA ≥ 60μV group of patients than theTWA< 60μV group. The index of interventricular dyssynchrony, Ts-RL, was significantly increased (75.6 ± 37.8 vs 59.9 ± 35.9 ms, P = 0.03) but not intraventricular dyssynchrony (all P > 0.05) in patients with TWA ≥ 60 μV compared with those with TWA < 60 μV. In addition, a weak but significant positive correlation was observed between TWA and Ts-RL (r = 0.25, P = 0.003). Multivariate analysis revealed that only Ts-RL (odds ratio 1.02, 95% confidence interval 1.00–1.03, P = 0.013) was independent predictor for increased TWA. Our results demonstrated that interventricular dyssynchrony in patients with CAD is associated with increased TWA. This suggests that interventricular dyssynchrony may contribute to proarrhythmic repolarization dispersion.Pacing and Clinical Electrophysiology 07/2011; 34(11):1503-10. · 1.35 Impact Factor -
Article: Effects of adenovirus-mediated delivery of the human hepatocyte growth factor gene in experimental radiation-induced heart disease.
[show abstract] [hide abstract]
ABSTRACT: Irradiation to the heart may lead to late cardiovascular complications. The purpose of this study was to investigate whether adenovirus-mediated delivery of the human hepatocyte growth factor gene could reduce post-irradiation damage of the rat heart and improve heart function. Twenty rats received single-dose irradiation of 20 Gy gamma ray locally to the heart and were randomized into two groups. Two weeks after irradiation, these two groups of rats received Ad-HGF or mock adenovirus vector intramyocardial injection, respectively. Another 10 rats served as sham-irradiated controls. At post-irradiation Day 120, myocardial perfusion was tested by myocardial contrast echocardiography with contrast agent injected intravenously. At post-irradiation Day 180, cardiac function was assessed using the Langendorff technique with an isolated working heart model, after which heart samples were collected for histological evaluation. Myocardial blood flow was significantly improved in HGF-treated animals as measured by myocardial contrast echocardiography at post-irradiation Day 120 . At post-irradiation Day 180, cardiac function was significantly improved in the HGF group compared with mock vector group, as measured by left ventricular peak systolic pressure (58.80 +/- 9.01 vs. 41.94 +/- 6.65 mm Hg, p < 0.05), the maximum dP/dt (5634 +/- 1303 vs. 1667 +/- 304 mm Hg/s, p < 0.01), and the minimum dP/dt (3477 +/- 1084 vs. 1566 +/- 499 mm Hg/s, p < 0.05). Picrosirius red staining analysis also revealed a significant reduction of fibrosis in the HGF group. Based on the study findings, hepatocyte growth factor gene transfer can attenuate radiation-induced cardiac injury and can preserve cardiac function.International journal of radiation oncology, biology, physics 12/2009; 75(5):1537-44. · 4.59 Impact Factor -
Article: A rare case of isolated non-compaction right ventricular myocardium.
Chinese medical journal 08/2009; 122(14):1718-20. · 0.86 Impact Factor -
Article: [Identification of differentially expressed genes in myocardium of patients with heart failure by human whole genomic oligonucleotide microarray-assisted pathways analysis].
[show abstract] [hide abstract]
ABSTRACT: To identify the differentially expressed gene profiles in myocardium of patients with heart failure using human whole genomic oligonucleotide microarray-assisted pathway analysis. Phalanx whole genomic oligonucleotide microarrays were used to detect the gene expression profiles of myocardium in four patients died of heart failure and 4 brain died patients without heart diseases. The microarray findings were confirmed by real-time quantitative reverse transcriptase-polymerase chain reaction. The genes with a threshold of 1.2 times fold-change were selected and BioCarta Pathway and KEGG (Kyoto Encyclopaedia of Genes and Genomes) pathway databases were used to identify functionally related gene pathways. A total of 2806 genes with differentially expression were detected between the failing and non-failing heart samples, expression changes of 399 genes were more than 2-folds. Eleven pathways were identified by BioCarta pathway database and sixteen pathways were identified by KEGG PATHWAY Database. Genomic microarray-assisted pathway analysis could help to identify gene expression profiles in failing heart.Zhonghua xin xue guan bing za zhi [Chinese journal of cardiovascular diseases] 03/2009; 37(2):120-5. -
Article: Progesterone levels and carotid intima-media thickness: a negative association in older northern Chinese men.
[show abstract] [hide abstract]
ABSTRACT: In experimental research, progesterone has been found to be beneficial to the central nervous and cardiovascular systems; however, its potential role in preventing atherosclerosis in elderly men remains unclear. In this prospective study, we analyzed data in 385 older men and women from 6 communities in Beijing, China, in order to discover whether progesterone is associated with carotid intima-media thickness and plaque occurrence. Intima-media thickness and atherosclerotic plaques were determined by use of ultrasonography. Sex-hormone levels were measured by immunoassay. The data were analyzed via analysis of covariance and logistic regression analysis; P < 0.05 was considered statistically significant. We found a negative association between mean intima-media thickness and progesterone concentration in men, before and after adjustments for such traditional risk factors of atherosclerosis as age, triglyceride levels, total and low-density lipoprotein cholesterol levels, high-sensitivity C-reactive protein, systolic blood pressure, waist-to-hip ratio, and body mass index (analysis of covariance, P = 0.007 and P = 0.015, respectively). However, no such association was found in women (P = 0.304 and P = 0.247, respectively). In the logistic regression model that was adjusted for the confounding factors of atherosclerosis, men with progesterone levels in the lowest quartile (<1.87 nmol/L) had more risk of higher intima-media thickness (odds ratio, 2.15; P = 0.042). Although further experimental and prospective studies are warranted in order to determine the mechanism of progesterone's function in atherosclerosis prevention, we conclude that progesterone concentrations are negatively associated with carotid artery atherosclerosis in northern Chinese men 60 years of age or older.Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital 01/2009; 36(4):303-8. · 0.65 Impact Factor -
Article: [The effect of Xuezhikang on ventricular diastolic function in hypertension].
[show abstract] [hide abstract]
ABSTRACT: To investigate whether statins have effect on diastolic function of both left and right ventricles in hypertensive patients. This is a randomized, mono-blind, placebo-controlled study. 120 systemic hypertensive (HT) patients with normal or slightly elevated cholesterol were randomized to placebo or Xuezhikang (1200 mg/d) for 24 weeks. Extended-release nifedipine was administrated to the HT patients. 30 healthy volunteers served as controls. Plasma were obtained at baseline and 24 weeks after Xuezhikang therapy. Cholesterol and carboxy-terminal peptide of procollagen type I (PIP) were measured. Early diastolic velocity (Em) and late diastolic velocity (Am) were obtained from right atrioventricular ring and left atrioventricular ring with pulsed wave tissue Doppler imaging. The levels of plasma PIP were higher in HT patients. After 24 weeks, the levels of plasma LDL-C, TC and PIP were significantly lower in Xuezhikang group than those in placebo group; Systolic and diastolic pressure were decreased both in placebo group and Xuezhikang group meanwhile pulse pressure was decreased and Em/Am ratio at left atrioventricular ring was higher in Xuezhikang group as compared with those in placebo group. In systemic hypertensive patients, Xuezhikang exerts a beneficial effect on diastolic function of left ventricule via controlling blood pressure, lowering blood lipid and inhibiting myocardial fibrosis.Zhonghua nei ke za zhi [Chinese journal of internal medicine] 11/2006; 45(10):811-4. -
Article: Numed Cheatham-Platinum stent and balloon in balloon delivery catheter for treatment of native coarctation of the aorta.
Chinese Medical Sciences Journal 04/2006; 21(1):65-7. -
Article: Insulin resistance and carotid atherosclerosis in 221 patients with potential hyperglycemia.
[show abstract] [hide abstract]
ABSTRACT: To investigate the relationship between insulin resistance and carotid atherosclerosis in patients with potential hyperglycemia. A total of 221 patients were recruited among those with potential hyperglycemia. All participants underwent physical examination, medical history interview, and 75 g oral glucose tolerance test. Venous blood was sampled for measurement of insulin and cholesterol levels. The intima-media thickness (IMT) in bilateral common carotid arteries was observed by B-mode ultrasound. Insulin resistance index was calculated by homeostasis model assessment (HOMA-IR). Subjects were stratified in quintiles according to HOMA-IR values. Risk factors and atherosclerotic parameters were analyzed. With HOMA-IR value increase, incidence of impaired glucose tolerance, diabetes mellitus, hypertension, and coronary artery disease increased, the levels of triglyceride (TG), low density lipoprotein cholesterol (LDL-C), fasting plasma glucose, 2 hour plasma glucose, and fasting insulin increased as well, while the level of high density lipoprotein cholesterol (HDL-C) decreased. Meanwhile, all atherosclerotic parameters increased. Multivariate regression analysis showed that TG, total cholesterol, HDL-C, LDL-C levels, and ln(HOMA-IR) were related to IMT, hence were risk factors for IMT increase. Insulin resistance is implicated in atherogenesis.Chinese Medical Sciences Journal 07/2005; 20(2):108-11. -
Article: Preparation and evaluation of poly(L-lactide-co-glycolide) (PLGA) microbubbles as a contrast agent for myocardial contrast echocardiography.
[show abstract] [hide abstract]
ABSTRACT: A kind of absorbable PLGA microbubble-based contrast agent (PLGA microspheres with porous or hollow inner structure) was fabricated by an improved double emulsion-solvent evaporation method. The contrast efficiency was evaluated and proved both in vitro and in vivo. By adjusting the polymer concentration and volume of the inner aqueous phase during the fabrication of microbubbles, the inner structure of the microbubbles could be controlled. Both air-filled and perfluoropropane-filled microbubbles can opacify the left ventricle. However, when compared with air-filled microbubbles, perfluoropropane-filled microbubbles can produce significantly longer enhancement in left ventricle in the dog model due to the lower diffusivity and lower solubility of perfluoropropane in blood. A suspension of perfluoropropane-filled PLGA microbubbles (1.8 microm average microbubbles size, 2 x 10(8) microbubbles/mL concentration) has successfully and safely achieved myocardial opacification in closed-chest dogs. A perfusion defect was observed in both of the two dogs with acute myocardial infarction with Power Contrast Imaging (PCI) triggered technology. In the examination of contrast in both ventricular and myocardial opacification, the high mechanical index (MI) was found to have superior contrast sensitivity over the low MI for PLGA-based contrast agents.Journal of Biomedical Materials Research Part B Applied Biomaterials 05/2005; 73(1):171-8. · 2.15 Impact Factor
Top co-authors
Top Journals
Institutions
-
2012–2013
-
301 Military Hospital
Beijing, Beijing Shi, China
-
-
2003–2013
-
307 Hospital of the Chinese People's Liberation Army
Beijing, Beijing Shi, China
-
-
2006
-
Chinese PLA General Hospital
Beijing, Beijing Shi, China
-
-
2005
-
Chinese Academy of Sciences
- State Key Laboratory of Polymer Physics and Chemistry (CIAC)
Beijing, Beijing Shi, China
-
