[Show abstract][Hide abstract] ABSTRACT: Bronchiectasis and asthma are different in many respects, but some patients have both conditions. Studies assessing the effect of bronchiectasis on asthma exacerbation are rare. The aim of this study is to investigate the effect of bronchiectasis on asthma exacerbation.
We enrolled 2,270 asthma patients who were followed up in our hospital. Fifty patients had bronchiectasis and asthma. We selected fifty age- and sex-matched controls from the 2,220 asthma patients without bronchiectasis, and assessed asthma exacerbation and its severity based on the annual incidence of total asthma exacerbation, annual prevalence of steroid use, and frequency of emergency room visits and hospitalizations due to asthma exacerbation in each group.
Fifty patients (2.2%) had bronchiectasis and asthma. The annual incidence of asthma exacerbation was higher in patients with asthma and bronchiectasis than in patients with asthma alone (1.08±1.68 vs. 0.35±0.42, p=0.004). The annual prevalence of steroid use (0.9±1.54 vs. 0.26±0.36, p=0.006) and the frequency of emergency room visits (0.46±0.84 vs. 0.02±0.13, p=0.001) due to asthma exacerbation were also higher in patients with asthma and bronchiectasis than in patients with asthma alone.
Bronchiectasis is associated with difficult asthma control.
Tuberculosis and Respiratory Diseases 11/2014; 77(5):209-214.
[Show abstract][Hide abstract] ABSTRACT: COPD Diagnosis & Evaluation PostersSESSION TYPE: Original Investigation PosterPRESENTED ON: Wednesday, October 30, 2013 at 01:30 PM - 02:30 PMPURPOSE: Older adults may face a variety of obstacles (comorbid conditions, physical challenges, or mental challenges) to the accurate use of dry powder inhalers (DPIs). The effectiveness of DPIs therapy education in the elderly patients has rarely been formally evaluated.METHODS: Newly diagnosed twenty nine patients with asthma or COPD were instructed two times on proper DPIs (diskus or turbuhaler) usage with 30 days intervals. The effectiveness of education was scored by using a inhaler specific checklist (12 items) after each education. We compared the scores of elderly patients and controls.RESULTS: Total practical performance scores after first education were not different in each group (11.1±0.7 vs 10.2±2.1, P=0.185). Total practical performance scores of elderly patients after second education were high than controls (9.8±1.3 vs 10.9±0.5, P=0.023). Major practical performance scores after first education were not different in each group (4.0±0.0 vs 3.8±0.8, P=0.291). Major practical performance scores after second education were not different in each group (3.75±0.5 vs 4.0±0.0, P=0.098).CONCLUSIONS: The effectiveness of DPIs therapy education in the elderly patients is similar to the young patients.CLINICAL IMPLICATIONS: The elderly patients could use DPIs effectively similar to the young age patients by optimal education.DISCLOSURE: The following authors have nothing to disclose: Jaehyung Lee, Sang-Hoon Kim, Byoung Hoon LeeNo Product/Research Disclosure Information.
[Show abstract][Hide abstract] ABSTRACT: Although benzalkonium chloride (BAC)-induced bronchoconstriction occurs in patients with bronchial asthma, BAC-containing nebulizer solutions are still being used in daily practice in Korea. The aim of this study was to evaluate the effects of inhaled aqueous solutions containing BAC.
Thirty subjects with bronchial asthma and 10 normal controls inhaled up to three 600 microg nebulized doses of BAC using a jet nebulizer. FEV1 (forced expiratory volume at one second) was measured 15 minutes after each dose. Inhalations were repeated every 20 minutes until FEV1 decreased by 15% or more (defined as BAC-induced bronchoconstriction) or the 3 doses were administered.
The percent fall in FEV1 in response to BAC inhalation was significantly higher in asthmatics than in normal subjects (p < 0.05). BAC administration in subjects with asthma reached a plateau (maximal effect). BAC-induced bronchoconstriction was found in 6 asthmatics (20%), with two responders after the 2nd inhalation and 4 after the 3rd inhalation. The percent fall in FEV1 in response to the 1st inhalation of BAC was significantly higher in asthmatics with higher bronchial hyperresponsiveness (BHR) than in those with lower BHR.
This study suggests that the available multi-dose nebulized solution is generally safe. However, significant bronchoconstriction can occur at a relatively low BAC dose in asthmatics with severe airway responsiveness.
The Korean Journal of Internal Medicine 12/2007; 22(4):244-8.