Sunil V. Pansare

Duke University, Durham, NC, United States

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Publications (3)15.35 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Novel strategies are required to combat pox virus infections, whether caused by escape of viruses such as monkeypox from indigenous areas or intentional release of smallpox. Anti-smallpox drugs with a unique mode of antiviral action, inhibition of transcription termination, were known but not therapeutically useful. Using a combinatorial method, variants of the basic isatin-beta-thiosemicarbazone structure were prepared and examined for cytotoxicity and antiviral activity in vaccinia virus- and cowpox virus-infected human cells. Potent and much more selective N-aminomethyl-isatin-beta-thiosemicarbazones were discovered.
    Journal of Medicinal Chemistry 05/2005; 48(8):3045-50. DOI:10.1021/jm049147h · 5.48 Impact Factor
  • Michael C. Pirrung, Sunil V. Pansare
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    ABSTRACT: Trityl isothiocyanate resin 1, prepared from commercially available trityl chloride resin, is a useful precursor of the trityl thiosemicarbazide resin 2. This resin can be employed in the solid-phase synthesis of a variety of supported isatin beta -thiosemicarbazones 4 and their Mannich derivatives 6. A variety of thioureas 7 can be easily prepared by the reaction of 1 with amines. The supported thioureas are directly and efficiently converted to 2-aminothiazole-5-carboxylates 8 by reaction with methyl 2-chloroacetoacetate.
    Journal of Combinatorial Chemistry 01/2001; 3(1):90-96. DOI:10.1021/cc000072m · 4.93 Impact Factor
  • M C Pirrung, S V Pansare
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    ABSTRACT: Trityl isothiocyanate resin [1], prepared from commercially available trityl chloride resin, is a useful precursor of the trityl thiosemicarbazide resin [2]. This resin can be employed in the solid-phase synthesis of a variety of supported isatin beta-thiosemicarbazones [4] and their Mannich derivatives [6]. A variety of thioureas [7] can be easily prepared by the reaction of [1] with amines. The supported thioureas are directly and efficiently converted to 2-aminothiazole-5-carboxylates [8] by reaction with methyl 2-chloroacetoacetate.
    Journal of Combinatorial Chemistry 01/2001; 3(1):90-6. · 4.93 Impact Factor