Publications (2)5.61 Total impact
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ABSTRACT: Novel strategies are required to combat pox virus infections, whether caused by escape of viruses such as monkeypox from indigenous areas or intentional release of smallpox. Anti-smallpox drugs with a unique mode of antiviral action, inhibition of transcription termination, were known but not therapeutically useful. Using a combinatorial method, variants of the basic isatin-beta-thiosemicarbazone structure were prepared and examined for cytotoxicity and antiviral activity in vaccinia virus- and cowpox virus-infected human cells. Potent and much more selective N-aminomethyl-isatin-beta-thiosemicarbazones were discovered.Journal of Medicinal Chemistry 05/2005; 48(8):3045-50. · 5.61 Impact Factor
- Journal of Combinatorial Chemistry - J COMB CHEM. 01/2001; 3(1):90-96.