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G Allan,
S Barbet,
Y Coffinier,
C Delerue,
D Deresmes,
M Diarra,
H Diesinger,
B Grandidier,
L Marcon,
T Melin, O Melnyk,
D Stievenard,
L Wirtz,
M Zdrojek
International Journal of Nanotechnology 01/2008; 5(6-8):631-648. · 1.01 Impact Factor
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ABSTRACT: We have determined the filling properties of nanogaps with chemically heterogeneous walls. The quantitative criteria we present allow the prediction of the liquid loading of the nanostructure. They can easily be applied in combination with contact-angle measurements on planar substrates of the nanogap materials. We present an application of the theory to a recently developed nanogap biosensor. Chemical force microscopy (CFM) is employed to characterize the initial silanol properties of the gap. The functionality of the complex surface chemistry of the biosensor is demonstrated by the observation of functionalized nanoparticles in the gap with its resulting characteristic current-voltage relationship.
Langmuir 12/2006; 22(23):9784-8. · 4.19 Impact Factor
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ABSTRACT: The covalent attachment of semicarbazide-functionalized layers to hydrogen-terminated Si(111) surfaces is reported. The surface modification, based on the photoinduced hydrosilylation of a Si(111) surface with protected semicarbazide-functionalized alkenes, was investigated by means of X-ray photoelectron spectroscopy (XPS), contact angle measurements, and atomic force microscopy (AFM). The removal of the protecting group yielded a semicarbazide-terminated monolayer which was reacted with peptides bearing a glyoxylyl group for site-specific alpha-oxo semicarbazone ligation.
Langmuir 03/2005; 21(4):1489-96. · 4.19 Impact Factor
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Peptides 2004, Proceedings: Bridges between Disciplines. 01/2005;
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ABSTRACT: A concept for the electrical detection of a biological interaction is proposed, mainly based on the conductance variation of a nanometer size-gap (typically less than 100 nm) between two planar electrodes. A functionalized surface was used in the vicinity of the gap in order to concentrate the ligand/receptor complex between the electrodes. The chemistry chosen for the immobilization of the ligand on the biosensor surface is compatible with peptide structures. The receptor in solution was labeled with gold particles which can be inserted into the gap. A significant conductance variation was observed without having to use a silver enhancer solution in the case of biotin/streptavidin or biotin/antibiotin antibodies model ligand/receptor interactions. © 2004 American Institute of Physics.
Applied Physics Letters 02/2004; 84(7):1213-1215. · 3.84 Impact Factor
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Journal of Peptide Science. 01/2004; 10(S2):P243.
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Proceedings of the 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2010.
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4èmes Journées Nationales en Nanosciences et Nanotechnologies, J3N 2009.
