[Show abstract][Hide abstract] ABSTRACT: Positron emission mammography (PEM) can offer a non-invasive method for the diagnosis of breast cancer. Metabolic images from PEM using 18F-fluoro-deoxy-glucose, contain unique information not available from conventional morphologic imaging techniques like X-ray radiography. In this work, the concept of Clear-PEM, the system presently developed in the frame of the Crystal Clear Collaboration at CERN, is described. Clear-PEM will be a dedicated scanner, offering better perspectives in terms of position resolution and detection sensitivity.
[Show abstract][Hide abstract] ABSTRACT: During the last decade there was a growing interest on the application of Positron Emission Tomography, PET, techniques to Breast Imaging. More recently, preliminary results suggested the use of dedicated devices to Breast Imaging using the same technique, the so-called Positron Emission Mammography cameras, PEM. In this article we review the arguments leading to a dedicated instrument. Based on these arguments we describe the concept of a PEM camera under development within the Crystal Clear Collaboration and the first results of its expected performance in terms of sensitivity and position resolution.
Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment 07/2004; · 1.32 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: The Clear-PEM prototype under development aims to improve early stage breast cancer diagnostics. The proposed device is based on cerium doped lutetium crystal matrices developed by the Crystal Clear Collaboration, as well as on modern data acquisition techniques. A series of Monte Carlo studies were performed to evaluate detection sensitivity, background rate and intrinsic spatial resolution in order to optimize the final detector concept. A description of the developed GEANT4 based simulation framework and PEM image reconstruction software is also presented in this paper. First simulation results indicates that Clear-PEM design significantly increases detection sensitivity in comparison with conventional PET cameras for breast cancer diagnostics. Count-rate simulation results are within operation limits for the data acquisition system, able to read 1 MHz event rate, allowing to take full profit of the large detector acceptance.