Anna Markiewicz

Publications of Anna Markiewicz

• [Transpupillary thermotherapy (TTT) for intraocular metastases in choroid].

  Authors: Bozena Romanowska-Dixon, Joanna Kowal, Arkadiusz Pogrzebielski, Anna Markiewicz

  Klinika oczna. 01/2011; 113(4-6):132-5.

  Uveal metastases are the most common intraocular malignant tumors. Most patients who develop metastatic carcinoma to the choroid are managed by radiation or chemotherapy. Since TTT is an optionalUveal metastases are the most common intraocular malignant tumors. Most patients who develop metastatic carcinoma to the choroid are managed by radiation or chemotherapy. Since TTT is an optional treatment for choroidal melanomas and hemangiomas, we ought to determine whether TIT is suitable for treatment of solitary choroidal metastasis at the posterior pole. To evaluate effectivenes of TTT treatment for intraocular metastases. 45 patients (59 eyes) with intraocular metastases were treated in the Ophthalmological Department of Jagiellonian University in Kraków. There were 30 women and 15 man, at the age 31-84 years (av. 57.5). The primary tumor was a breast cancer in 22 women, lung cancer in 5 men and 2 women, kidney (3), colon (2), uterus (1), larynx (1), testicle (1), esophagus (1). 10 patients had also metastases in other organs. TTT was performed in all treated eyes, in 11 combined with 106Ru brachytherapy (BT). Chemotherapy as adjuvant treatment was performed in 18 patients. The results of treatment were evaluated in mean 14.5 months (1-61) follow-up. After TTT, tumor shrinking was observed in most treated tumors (in 37 eyes, 62.7%), inhibition of tumor growth in 5 (8.4%), and in 4 cases (6.7%) progression of tumor growth. In 3 cases (5.1%) with flat scar and intraocular tumor shrinking, extrascleral extension located close to the tumor base appeared after treatment (TTT in 2 eyes, TTT combined with BT in one case). TTT is an effective treatment method for small choroidal metastases located in the posterior pole. TTT combined with 106Ru brachytherapy can be useful treatment in medium sized choroidal metastases. Efficient results encourage further application of thermotherapy in the treatment of intraocular metastases. It allows for the conservative treatment of the eyeball and also useful visual acuity. Extraocular extension appearing after TT needs further study.

• [Radiation optic neuropathy after the brachytherapy of the uveal melanoma]

  Authors: Iwona Szuścik, Bozena Romanowska-Dixon, Anna Markiewicz, Arkadiusz Pogrzebielski, Barbara Jakubowska

  Klinika oczna. 02/2006; 108(7-9):278-80.

  PURPOSE: The evaluate the frequency of radiation of the optic neuropathy (RON) and its influence on visual acuity in patients with choroidal melanoma treated by brachytherapy. MATERIAL AND METHODS:PURPOSE: The evaluate the frequency of radiation of the optic neuropathy (RON) and its influence on visual acuity in patients with choroidal melanoma treated by brachytherapy. MATERIAL AND METHODS: We analyzed 583 patients with choroidal melanoma, treated with ruthenium (106Ru) or iodine (125I) plaques in Ophthalmology Department of Jagiellonian University, between 1996 and 2004 year. The frequency of RON, its influence on loss of vision, according to a kind of the used isotope, tumor size and location were analyzed. Diagnosis of RON was established on the base of characteristic symptoms in the eye fundus. RESULTS: The frequency of RON was significantly higher in cases treated by 125I vs 106Ru (14% vs 8.2%, p = 0.0014), in cases of tumors located in the posterior pole (31.3%, p = 0.012), and in cases of tumor thickness 3-8 mm (27.5%, p = 0.033). In most of patients we observed major deterioration of visual acuity. CONCLUSIONS: The radiation of the optic neuropathy was seen often after iodine BT, tumors located in the posterior pole of fundus, with thickness 3-8 mm.

• [Optic disc melanocytoma]

  Authors: Arkadiusz Pogrzebielski, Bozena Romanowska-Dixon, Barbara Jakubowska, Iwona Szuścik, Anna Markiewicz

  Klinika oczna. 02/2005; 107(4-6):361-4.

  PURPOSE: Presentation of the cases of melanocytoma observed in the latest time in our clinic. MATERIAL AND METHODS: We present 2 cases - one in a 41 years old women S.M. and in a 77 years old womenPURPOSE: Presentation of the cases of melanocytoma observed in the latest time in our clinic. MATERIAL AND METHODS: We present 2 cases - one in a 41 years old women S.M. and in a 77 years old women P.J. CONCLUSIONS: In case of melanocytoma there should be performed specialistic ancillary tests and the patients should be observed with photographic documentation.