[Show abstract][Hide abstract] ABSTRACT: Due to the difficulty in spinal cord regeneration with biological methods, the microelectronic neural bridge, a new concept based on microelectronic technology, is presented. The microelectronic system has been realized in the forms of hybrid and integrated circuits. The integrated circuits for neural signal detection, stimulation, and regeneration are realized in a CMOS process. In animal experiments with 100 toads, 48 rats, and 3 rabbits, nerve signals have been successfully detected from spinal cords and sciatic nerves, and functional electrical stimulation has been carried out for spinal cords and sciatic nerves. When the microelectronic system is bridged between the controlling and stimulated nerve, the relevant motion of legs and nerve signal waveforms, which are stimulated by the evoked or spontaneous nerve signal through such a system, have been observed. Therefore, the feasibility of the presented method was demonstrated.
[Show abstract][Hide abstract] ABSTRACT: This paper presents a fully integrated and low power CMOS amplifier for neural signal recording. It consists of a band-filtering preamp and a current-mode instrumentation amplifier. The design approach and the noise optimizing are briefly discussed. A 0.6 μm CMOS technology is used for the design of the amplifier IC. The simulation shows that it has a pass band from 59Hz to 12.8 kHz and a mid-band gain of 80 dB. The supply voltage is ±1.25V and the power consumption is 180µW.
Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 01/2005; 5:5250-3. DOI:10.1109/IEMBS.2005.1615663