[Show abstract][Hide abstract] ABSTRACT: Fifty isolates of Burkholderia pseudomallei and 15 isolates of Burkholderia mallei were tested for their susceptibilities to 35 antimicrobial agents, including agents not previously tested against these bacteria.
MICs were determined by agar dilution in Mueller-Hinton medium.
Among the antibiotics tested, lower MICs were obtained with imipenem, ceftazidime, piperacillin, piperacillin/tazobactam, doxycycline and minocycline. Fluoroquinolones and aminoglycosides had poor activities. A single clinical isolate of B. pseudomallei was resistant to ceftazidime, co-amoxiclav and doxycycline but remained susceptible to imipenem.
Although B. mallei MICs are often lower, the overall results underline the importance of resistance in both species. The susceptibilities measured are consistent with the current recommendations for the treatment of B. pseudomallei and B. mallei infections.
[Show abstract][Hide abstract] ABSTRACT: Ninety-four isolates of Yersinia pestis collected by the French army between 1964 and 1988 were evaluated for their susceptibilities to 24 antibiotics by the agar dilution method. All the isolates were susceptible to beta-lactam antibiotics including imipenem, to fluoroquinolones, aminoglycosides and to doxycycline. The most active compounds were fluoroquinolone antibiotics, third-generation cephalosporins and aminoglycosides.
[Show abstract][Hide abstract] ABSTRACT: Ninety-six isolates of Bacillus anthracis recovered in France between 1994 and 2000 were tested for their susceptibilities to 25 different antibiotics. Resistance to penicillin G and amoxicillin was 11.5%. All of the isolates were resistant to cotrimoxazole and susceptible to doxycycline, ciprofloxacin, pefloxacin, levofloxacin, teicoplanin, vancomycin, clindamycin, imipenem, and rifampin.