John R. Weisz

Harvard University, Cambridge, Massachusetts, United States

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Publications (218)919.59 Total impact

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    ABSTRACT: Child depression is an impairing condition for which tested treatments have shown relatively modest mean effects. One possible explanation is that the treatments have generally adopted an individual child focus, without addressing the dysfunctional parent-child interactions that often accompany child depression. The present study provides preliminary evidence bearing on this hypothesis, using data from a treatment outcome study in which clinically referred children with a depression diagnosis could receive individual cognitive behavioral therapy (CBT) focusing on the depression or behavioral parent training (BPT) focusing on comorbid conduct problems. Among children in the study who met criteria for Diagnostic and Statistical Manual of Mental Disorders (4th ed.) depressive disorders, we identified two groups, matched on gender and age: 15 who received only CBT focused on child depression and 15 who received only BPT focused on child conduct problems. Children were 7 to 13, 20 of whom were male, and race included Caucasian (17), Latino (5), African American (2), and multirace (6). Measures assessed depressive diagnoses and symptoms, as well as parenting stress. Analyses focused on whether BPT alone might lead to reduced depression, and if so how that reduction would compare to the depression reduction achieved through CBT that focused on depression. Both groups showed significant reductions from pre- to post-treatment in depressive diagnoses and depression symptoms, and there were no BPT versus CBT group differences at post-treatment. BPT that focuses on child conduct problems, with no emphasis on depression treatment, may produce significant depression reduction in comorbid children who meet criteria for depressive disorders.
    Journal of Clinical Child & Adolescent Psychology 07/2015; DOI:10.1080/15374416.2015.1050722 · 1.92 Impact Factor
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    Jessica L. Schleider, John R. Weisz
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    ABSTRACT: Research shows significant relations between entity theories—i.e., beliefs that traits and abilities are fixed and unchangeable—and youth mental health problems. A common interpretation has been that entity theories lead to mental health problems, but an alternative possibility is that mental health problems predict entity theories. The two predictive models carry different implications for developmental psychopathology and for intervention design. We used a longitudinal design to test the plausibility of the two models with respect to entity theories of thoughts, feelings, and behavior, examining associations between entity theories in these domains and mental health outcomes in early adolescents across three assessment points during one school year (N=59, 52% female, ages 11-14, no attrition at any time point). Findings showed concurrent, associations between entity theories and mental health problems across all assessment points. Importantly, baseline entity theories did not predict increases in mental health problems; instead, baseline mental health problems predicted increased entity theories over time. In addition, when symptom clusters were assessed individually, greater youth internalizing problems (but not externalizing problems) predicted increases in entity theories of thoughts, feelings, and behaviors across the study period. The findings support an alternative to the predictive model most commonly proposed. They suggest that youth mental health problems, and especially internalizing problems, may contribute to the development of certain kinds of entity theories.
    International Society for Research in Child and Adolescent Psychopathology, Portland, OR; 07/2015
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    ABSTRACT: Parent engagement in treatment for child disruptive behavior has been associated with improved child outcomes in care. However, many families who enter care do not receive an adequate dose of treatment, and parents are often not involved. We examined therapists' use of psychoeducation, a therapeutic practice used to present factual information about target problems and treatments, and its association with parent engagement in child psychotherapy. Participants were drawn from the Child System and Treatment Enhancement Projects' multisite trial contrasting standard evidence-based treatments, modular treatment, or usual care. We included an ethnically diverse sample of 46 youth (ages 7-13) who received treatment for disruptive behavior in modular treatment or usual care. A reliable observational coding system was developed to assess therapists' in-session use of psychoeducation strategies (e.g., discussing causes of misbehavior, describing and providing rationale for treatment, etc.), as well as other engagement strategies (e.g., collaborative goal setting, managing expectations, etc.), in the early phase of treatment. Findings revealed that modular treatment therapists provided more psychoeducation and other engagement strategies compared with usual care therapists. Furthermore, psychoeducation strategies employed by therapists early on uniquely predicted subsequent parent involvement in treatment, over and above the use of other engagement strategies. Finally, therapists' use of the psychoeducation strategy of discussing causes of child's misbehavior mediated the effect of treatment condition on parent involvement in their child's therapy. These findings suggest that the implementation of psychoeducation strategies upon entry into care promotes parent involvement in child psychotherapy for disruptive behavior.
    Journal of Clinical Child & Adolescent Psychology 06/2015; DOI:10.1080/15374416.2015.1038826 · 1.92 Impact Factor
  • Mei Yi Ng, Dikla Eckshtain, John R Weisz
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    ABSTRACT: The modest efficacy of psychological interventions for youth depression, including evidence-based psychotherapies (EBPs), suggests a question: Do the therapy components match the coping strategies youths find helpful when dealing with depressed mood? Answering this question may help strengthen treatments. We asked 105 middle schoolers across a range of depression symptom levels to identify the coping strategies they used when they felt sad (habitual responses) and those that made them feel better (perceived-effective responses). Habitual and perceived-effective responses were coded for resemblance to EBPs, and each youth's habitual responses were coded for their match to the youth's perceived-effective responses. Most perceived-effective responses (92.6%) matched EBP components (most frequent: Behavioral Activation); however, 65.0% of the EBP components did not match any youth's habitual or perceived-effective responses. Youths at higher depression symptom levels were significantly more likely than low-symptom youths to report (a) habitual responses that did not match EBP components, (b) habitual responses that did not match their own perceived-effective responses, and (c) perceiving no effective response. The higher their depression symptom level, the less likely youths were to use strategies identified by researchers and perceived by themselves as effective, and the less likely they were to identify any perceived-effective coping strategy. The findings suggest a need to (a) determine which EBP components do in fact enhance youth coping, (b) design the most effective ways to help youths master those effective components, and (c) facilitate more frequent use of those strategies the youths already find effective.
    Journal of Clinical Child & Adolescent Psychology 06/2015; DOI:10.1080/15374416.2015.1041591 · 1.92 Impact Factor
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    ABSTRACT: Mental disorders are among the largest contributors to the global burden of disease. Since the cessation of the Sierra Leonean civil war in 2002, there have been few mental health resources available for war-affected youth. Co-occurring psychological problems are commonly reported by youth in the post-conflict setting, suggesting a need for evidence-based interventions that cater to comorbid psychological difficulties. This feasibility study outlines the implementation and evaluation of a mixed-methods approach for developing and piloting a culturally grounded group mental health treatment-the Youth Readiness Intervention (YRI)-for war-affected Sierra Leonean youth. Participating youth (N = 32; 50% female; ages, 15-24 years) were allocated to one of four gender- and age-stratified groups, facilitated by gender-matched Sierra Leonean interventionists. The intervention comprised adapted cognitive behavioral therapy techniques to address issues pertinent to war-affected youth. Analyses comprised assessments of reliable symptom change, mental health, functional adaptation, and interventionist fidelity outcomes. The YRI was found to be acceptable, feasible and associated with reliable changes in internalizing and externalizing symptoms and improvements in functional impairments and emotion regulation (mean effect size, d = .64). Youth struggling with the mental health consequences of past trauma due to war merit special attention. The YRI presents a feasible and acceptable intervention for use in this low resource setting. A randomized controlled trial is planned to further test intervention effectiveness and scalability. Copyright © 2015. Published by Elsevier Inc.
    Journal of Adolescent Health 06/2015; 56(6):606-611. DOI:10.1016/j.jadohealth.2015.01.020 · 2.75 Impact Factor
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    ABSTRACT: The measurement of treatment adherence (a component of treatment integrity defined as the extent to which a treatment is delivered as intended) is a critical element in treatment evaluation research. This article presents initial psychometric data for scores on the Cognitive-Behavioral Therapy Adherence Scale for Youth Anxiety (CBAY-A), an observational measure designed to be sensitive to common practice elements found in individual cognitive-behavioral therapy (ICBT) for youth anxiety. Therapy sessions (N = 954) from 1 efficacy and 1 effectiveness study of ICBT for youth anxiety were independently rated by 2 coders. Interrater reliability (as gauged by intraclass correlation coefficients) for the item scores averaged 0.77 (SD = 0.15; range .48 to .80). The CBAY-A item and scale (skills, model, total) scores demonstrated evidence of convergent and discriminant validity with an observational measure of therapeutic interventions and an observational measure of the alliance. The CBAY-A item and scale scores also discriminated between therapists delivering ICBT in research and practice settings and therapists delivering nonmanualized usual clinical care. We discuss the importance of replicating these psychometric findings in different samples and highlight possible application of an adherence measure in testing integrity-outcome relations. (PsycINFO Database Record (c) 2015 APA, all rights reserved).
    Psychological Assessment 05/2015; DOI:10.1037/pas0000141 · 2.99 Impact Factor
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    ABSTRACT: To investigate the association between protocol design and therapist satisfaction in the Child STEPs Randomized Effectiveness Trial (Weisz et al., 2012). Therapist report was obtained at the close of 145 cases seen by 77 therapists, each of whom was randomized to a Standard evidence-based treatment (EBT), modular EBT, or usual care (UC) condition. Analysis of satisfaction items revealed 2 correlated factors representing perceived effectiveness and perceived responsiveness of the treatments. Therapist total satisfaction scores were significantly higher for cases in the modular condition than for those in the standard EBT or UC conditions. With regard to specific dimensions, the modular and UC cases were rated significantly higher than standard EBT cases on the Responsiveness scale, whereas modular and standard EBT cases were rated significantly higher than UC on the Effectiveness scale. Finally, increases in Effectiveness scores from first to second case were significantly larger for Modular cases than for cases in both other study conditions, and increases from first to second case in Total Satisfaction scores were significantly larger for modular cases than for UC cases. Therapist satisfaction with a treatment approach has independent dimensions, which can vary as a function of the protocol design. By virtue of being perceived as more effective than UC and more responsive than standard EBTs, the modular protocol design was also viewed as more overall satisfying than both, and secondary analysis suggested that these results were not due to mere first impressions of the protocols. (PsycINFO Database Record (c) 2015 APA, all rights reserved).
    Journal of Consulting and Clinical Psychology 05/2015; DOI:10.1037/a0039301 · 4.85 Impact Factor
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    ABSTRACT: Efforts to identify empirically supported treatments (ESTs) for youth's mental health problems are valuable, but the descriptor empirically supported does not guarantee that a treatment will work well in everyday clinical use. The voltage drop often seen when ESTs move from efficacy studies to clinical practice contexts may reflect limited exposure to real-world conditions during development and testing. One result may be interventions that are focused more narrowly and are more linear than the clinical practice they are designed to enhance. In this article, we suggest three strategies for building and refining ESTs that are robust for real-world application: (a) designing interventions to fit the contexts of youth treatment, (b) structuring interventions that can be tailored to fit individual youth characteristics, and (c) building programs for nontraditional intervention contexts. In addition, we describe how to develop interventions that are ready for practical implementation: the deployment-focused model.
    Child Development Perspectives 04/2015; 9(2). DOI:10.1111/cdep.12118 · 1.56 Impact Factor
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    ABSTRACT: Most youth psychotherapy research involves conditions quite unlike the clinical practice it is designed to strengthen. Most studies have not tested interventions with clinically referred youths and practicing clinicians in clinical care settings, nor have they tested whether new treatments produce better outcomes than usual practice. Limited exposure to real-world conditions and questions may partially explain why empirically supported treatments show such modest effects when tested under more representative conditions, against usual care. Our deployment-focused model calls for intervention development and testing with the kinds of participants (e.g., clients and clinicians) and in the contexts (e.g., clinics) for which the interventions are ultimately intended, and for randomized comparisons to usual clinical care. Research with the Child STEPs (system and treatment enhancement projects) treatment approach illustrates the methods and potential benefits of the deployment-focused model. Findings supporting Child STEPs are but one part of a rich research matrix needed to shrink the gap between intervention research and clinical practice.
    Annual Review of Clinical Psychology 03/2015; 11(1):139-163. DOI:10.1146/annurev-clinpsy-032814-112820 · 12.92 Impact Factor
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    ABSTRACT: Crohn's disease (CD) is associated with depression. It is unclear if psychosocial interventions offer benefit for depressive symptoms during active CD. In this secondary analysis of a larger study of treating depression in pediatric inflammatory bowel disease, we assessed whether cognitive behavioral therapy (CBT) would differentiate from supportive nondirective therapy in treating depression and disease activity in youth with CD. We also explored whether somatic depressive symptoms showed a different pattern of response in the overall sample and the subset with active inflammatory bowel disease. Youth with depression and CD (n = 161) were randomized to 3 months of CBT (teaching coping skills) or supportive nondirective therapy (supportive listening). Depressive severity was measured using the Children's Depression Rating Scale-Revised (CDRS-R) with the somatic depressive subtype consisting of those CDRS-R items, which significantly correlated with CD activity. Disease activity was measured by the Pediatric Crohn's disease Activity Index. Given the potential confound of higher dose steroids, subanalyses excluded subjects on >20 mg/d prednisone equivalent (n = 34). Total CDRS-R scores in the overall sample significantly decreased over time after both treatments (P < 0.0001). Treatment with CBT was associated with a significantly greater improvement in the Pediatric Crohn's disease Activity Index (P = 0.05) and somatic depressive subtype (P = 0.03) in those with active inflammatory bowel disease (n = 95) compared with supportive nondirective therapy. After excluding those on steroids (n = 34), there was a significant improvement in total CDRS-R (P = 0.03) and in Pediatric Crohn's disease Activity Index (P = 0.03) after CBT. Psychotherapy may be a useful adjunct to treat depression in the context of CD-related inflammation in youth who are not concurrently on higher dose steroids.
    Inflammatory Bowel Diseases 03/2015; 21(6). DOI:10.1097/MIB.0000000000000358 · 5.48 Impact Factor
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    ABSTRACT: Objective: Research has examined the effects of parental psychopathology, family functioning, and caregiver strain on treatment response in anxious youths. Although these variables have shown individual links to youth treatment response, theoretical models for their combined effects remain unexplored. This study tested the hypothesis that improvements in family functioning and reductions in caregiver strain explained the effects of parental psychopathology on youth treatment outcome in an anxiety treatment trial. Method: A multiple mediation technique was used to test the proposed model across independent evaluator (IE), parent, and youth informants in 488 youths, aged 7-17 years (50% female; mean age = 10.7) meeting Diagnostic and Statistical Manual of Mental Disorders criteria for social phobia, separation anxiety, and/or generalized anxiety disorder. Youths were randomized to receive 12 weeks of cognitive-behavioral treatment (Coping Cat), medication (sertraline), their combination, or a pill placebo. At pre- and posttreatment, parents completed self-report measures of global psychopathology symptoms, family functioning, and caregiver strain; parents, youths, and IEs rated youths' anxiety symptom severity. Results: Changes in family functioning and caregiver strain jointly explained relations between parental psychopathology and reductions in youth anxiety. Specifically, across IE and parent informants, families with higher pretreatment parental psychopathology showed more improvement in family functioning and caregiver strain, which in turn predicted greater youth anxiety reductions. Further, higher pretreatment parental psychopathology predicted greater caregiver strain reductions and, in turn, greater youth anxiety reductions, based on youths' reports of their own anxiety. Conclusions: Findings suggest that improvements in family functioning and reductions in caregiver strain can influence treatment outcomes for anxious youths, especially among youths with more distressed parents. (PsycINFO Database Record (c) 2014 APA, all rights reserved).
    Journal of Consulting and Clinical Psychology 02/2015; 83(1):213-224. DOI:10.1037/a0037935 · 4.85 Impact Factor
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    Jessica L. Schleider, John R. Weisz
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    ABSTRACT: Extensive evidence links youth mental health to family functioning, highlighting the need to document causal pathways. This will require longitudinal studies, but traditional methods for longitudinal clinical research have several limitations, including high cost and resource demands, underrepresentation of fathers, and attrition bias. We tested whether an online alternative might address limitations of—and thus provide a useful complement to—traditional methods. We used the Mechanical Turk (MTurk) survey program to obtain reports from parents (N=177) on family functioning, the parents’ own symptoms, their children’s behavioral and emotional problems, and parenting stress, with assessments in three consecutive months. Parents provided largely high-quality data (e.g., passed consistency checks); measures showed acceptable psychometrics at each time-point; and correlations among study measures paralleled those observed in prior research. Compared to prior studies using traditional longitudinal methods, the MTurk method was (a) much lower in cost and resource requirements, (b) successful in enrolling fathers, (c) comparable in participant attrition, and (c) similar in attrition bias, participant race/ethnicity, and enrollment of single parents. Overall, findings suggest that MTurk is a viable tool with its own set of strengths and limitations, and a potentially useful complement to traditional longitudinal methods. In particular, MTurk might be a cost-effective first step in generating causal hypotheses about family processes and youth mental health, for later testing via more traditional methods.
    Journal of Child and Family Studies 01/2015; in press. DOI:10.1007/s10826-015-0126-6 · 1.42 Impact Factor
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    ABSTRACT: This study expands upon the Chorpita et al. (J Consult Clin Psychol 81:999-1009, 2013) findings by examining the impact of treatment protocol on youths' service utilization up to 2 years after starting an episode of: standard manualized treatment (Standard); modular treatment (Modular); or usual care (UC). Results showed that youths who received Modular accessed fewer service settings at their one-year follow-up relative to youths who received Standard or UC. Findings suggest that modular treatment may offer an advantage over standardized treatment manuals and UC in terms of sustained clinical benefits, and highlight the importance of treatment design considerations for service systems.
    Administration and Policy in Mental Health and Mental Health Services Research 01/2015; DOI:10.1007/s10488-015-0625-1 · 3.44 Impact Factor
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    ABSTRACT: This study tested whether family income and stress in the parent-youth relationship might mediate links between parent symptoms and youth problems, and whether the process might differ for youth externalizing versus internalizing problems. We used a multiple mediation technique to test pathways by which family income and stress in the parent-child relationship might relate to parent-youth symptom associations in a sample of clinically-referred 7-13 year-olds (32 % female; M age = 10.16 years). Family income and stress jointly mediated the relation between parent symptoms and youth externalizing problems but not between parent symptoms and youth internalizing problems. Future longitudinal research should investigate whether low income and parent-youth stress may deplete the parental resources needed to manage youth externalizing behavior. This study extends existing literature by suggesting a specific pattern by which two identified risk factors for youth problems may operate jointly, and by showing specificity to externalizing problems.
    Child Psychiatry and Human Development 01/2015; DOI:10.1007/s10578-014-0446-6 · 1.93 Impact Factor
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    ABSTRACT: Objective Youth in war-affected regions are at risk for poor psychological, social, and educational outcomes. Effective interventions are needed to improve mental health, social behavior, and school functioning. This randomized controlled trial tested the effectiveness of a 10-session cognitive-behavioral therapy (CBT)-based group mental health intervention for multisymptomatic war-affected youth (aged 15-24) in Sierra Leone. Method War-affected youth identified by elevated distress and impairment via community screening were randomized (stratified by sex and age) to the Youth Readiness Intervention (YRI) (n=222) or a control condition (n=214). After treatment, youth were again randomized and offered an education subsidy immediately (n=220) or waitlisted (n=216). Emotion regulation, psychological distress, prosocial attitudes/behaviors, social support, functional impairment, and posttraumatic stress disorder (PTSD) symptoms were assessed at pre- and post-intervention and at six-month follow-up. For youth in school, enrollment, attendance, and classroom performance were assessed after eight months. Linear mixed-effects regressions evaluated outcomes. Results The YRI showed significant post-intervention effects on emotion regulation, prosocial attitudes/behaviors, social support, and reduced functional impairment, and significant follow-up effects on school enrollment, school attendance, and classroom behavior. In contrast, education subsidy was associated with better attendance but had no effect on mental health or functioning, school retention, or classroom behavior. Interactions between education subsidy and YRI were not significant. Conclusion YRI produced acute improvements in mental health and functioning as well as longer-term effects on school engagement and behavior, suggesting efficacy in preparing war-affected youth for educational and vocational opportunities.
    Journal of the American Academy of Child & Adolescent Psychiatry 12/2014; 53(12). DOI:10.1016/j.jaac.2014.09.011 · 6.35 Impact Factor
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    ABSTRACT: Compared to youths who believe personal traits are malleable, those who believe personal traits are fixed experience more academic and self-regulatory distress. Recently, studies have begun to explore relations between beliefs about the malleability of personal traits, or implicit theories, and youth mental health problems. We synthesized this emerging body of research in youths (ages 4-19) across 45 effect sizes from 17 research reports. Studies were included if they assessed youth mental health and implicit theories and did not manipulate implicit theory or affective/behavioral states prior to measuring these variables. Our random-effects meta-analysis using clustered data analysis techniques (i.e., effect sizes nested within samples) revealed that youths holding entity theories—the belief that personal traits are fixed—showed more pronounced mental health problems. This association between entity theories and mental health problems was evident across methodological factors and problem types (internalizing versus externalizing; psychopathology versus general distress). Limitations include the small number of eligible studies, insufficient data to test further demographic moderators, and few longitudinal studies on this topic. Overall, findings support the value of parsing the implicit theory-mental health link in youths. Implicit theories may prove to be promising targets for treatment and prevention of youth mental health problems.
    Clinical Psychology Review 11/2014; in press. DOI:10.1016/j.cpr.2014.11.001 · 7.18 Impact Factor
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    ABSTRACT: Observational measures to assess implementation integrity (the extent to which components of an evidence-based treatment are delivered as intended) are needed. The authors evaluated the reliability of the scores and the validity of the score interpretations for the Therapy Process Observational Coding System for Child Psychotherapy-Revised Strategies scale (TPOCS-RS; McLeod, 2010) and assessed the potential of the TPOCS-RS to assess treatment differentiation, a component of implementation integrity. The TPOCS-RS includes 5 theory-based subscales (Cognitive, Behavioral, Psychodynamic, Client-Centered, and Family). Using the TPOCS-RS, coders independently rated 954 sessions conducted with 89 children (M age = 10.56, SD = 2.00; age 7-15 years; 65.20% White) diagnosed with a primary anxiety disorder who received different treatments (manual-based vs. nonmanualized) across settings (research vs. practice). Coders produced reliable ratings at the item level (M intraclass correlation coefficient = .76, SD = .18). Analyses support the construct validity of the Cognitive and Behavioral subscale scores and, to a lesser extent, the Psychodynamic, Family, and Client-Centered subscale scores. Correlations among the TPOCS-RS subscale scores and between the TPOCS-RS subscale scores and observational ratings of the alliance and client involvement were moderate suggesting independence of the subscale scores. Moreover, the TPOCS-RS showed promise for assessing implementation integrity as the TPOCS-RS subscale scores, as hypothesized, discriminated between manual-guided treatment delivered across research and practice settings and nonmanualized usual care. The findings support the potential of the TPOCS-RS Cognitive and Behavioral subscales to assess treatment differentiation in implementation research. Results for the remaining subscales are promising, although further research is needed. (PsycINFO Database Record (c) 2014 APA, all rights reserved).
    Psychological Assessment 10/2014; 27(1). DOI:10.1037/pas0000037 · 2.99 Impact Factor
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    ABSTRACT: Identifying factors that promote sustained implementation of evidence-based treatments (EBTs) after therapists receive training is critical for professional psychology. To address the field’s minimal knowledge in this area, we interviewed community-based therapists (N = 23) who had completed intensive training in cognitive behavioral therapy (CBT) for either anxiety or depression as part of a randomized effectiveness trial (Southam-Gerow et al., 2010; Weisz et al., 2009). Therapists were interviewed three to five years after completion of the initial trial, representing one of the longest-term follow-ups of therapist practices after training. Therapists viewed each protocol and their individual CBT strategies as effective and appropriate for the majority of their current anxiety and depression caseloads. However, therapists used parts of each protocol much more frequently than the protocol as a whole (i.e., 78.5% used parts of the Coping Cat, and 7.5% used the whole protocol; 58.6% used parts of the PASCET, and 20% used the whole protocol). Therapists reported using problem-solving the most and exposure exercises the least for current anxious cases; they used cognitive restructuring the most and homework the least for current depression cases. Interventions that were more difficult to implement in usual care settings were less likely to be sustained. Future efforts should evaluate the characteristics and structure of EBTs that are most acceptable to therapists and should investigate which kinds of ongoing learning supports will maintain therapist skills in and continued use of EBTs. Keywords: Therapist training, Dissemination, Implementation
    Professional Psychology Research and Practice 10/2014; 46(1). DOI:10.1037/a0038000 · 1.34 Impact Factor
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    ABSTRACT: Objective: Pediatric inflammatory bowel disease (IBD) is associated with high rates of depression. This study compared the efficacy of cognitive behavioral therapy (CBT) to supportive nondirective therapy (SNDT) in treating youth with comorbid IBD and depression. Method: Youth (51% female and 49% male; age 9-17 years, mean age 14.3 years) with depression and Crohn's disease (n = 161) or ulcerative colitis (n = 56) were randomly assigned to a 3-month course of CBT or SNDT. The primary outcome was comparative reduction in depressive symptom severity; secondary outcomes were depression remission, increase in depression response, and improved health-related adjustment and IBD activity. Results: A total of 178 participants (82%) completed the 3-month intervention. Both psychotherapies resulted in significant reductions in total Children's Depression Rating Scale Revised score (37.3% for CBT and 31.9% for SNDT), but the difference between the 2 treatments was not significant (p = .16). There were large pre-post effect sizes for each treatment (d = 1.31 for CBT and d =- 1.30 for SNDT). More than 65% of youth had a complete remission of depression at 3 months, with no difference between CBT and SNDT (67.8% and 63.2%, respectively). Compared to SNDT, CBT was associated with a greater reduction in IBD activity (p = .04) but no greater improvement on the Clinical Global Assessment Scale (p = .06) and health-related quality of life (IMPACT-III scale) (p = .07). Conclusion: This is the first randomized controlled study to suggest improvements in depression severity, global functioning, quality of life, and disease activity in a physically ill pediatric cohort treated with psychotherapy. Clinical trial registration information Reducing Depressive Symptoms in Physically III Youth; http://clinical trials.gov; NCT00534911.
    Journal of the American Academy of Child and Adolescent Psychiatry 07/2014; 53(7):726-35. DOI:10.1016/j.jaac.2014.04.014 · 6.35 Impact Factor
  • John R Weisz
    American Journal of Psychiatry 06/2014; 171(6):600-602. DOI:10.1176/appi.ajp.2014.14030361 · 13.56 Impact Factor

Publication Stats

13k Citations
919.59 Total Impact Points

Institutions

  • 1970–2015
    • Harvard University
      • Department of Psychology
      Cambridge, Massachusetts, United States
  • 2013
    • University of Washington Seattle
      • Department of Psychology
      Seattle, Washington, United States
  • 1991–2013
    • University of California, Los Angeles
      • Department of Psychology
      Los Ángeles, California, United States
  • 2009
    • University of Hawaiʻi at Mānoa
      • Department of Psychology
      Honolulu, HI, United States
    • Cardiff University
      • Department of Psychological Medicine and Neurology
      Cardiff, Wales, United Kingdom
  • 2006
    • Texas A&M University
      • Department of Educational Psychology
      College Station, TX, United States
  • 1989–2006
    • Vanderbilt University
      • Department of Psychology and Human Development
      Nashville, Michigan, United States
  • 2003–2005
    • Virginia Commonwealth University
      • • Department of Psychiatry
      • • Department of Psychology
      Richmond, VA, United States
  • 1998–2000
    • Yale University
      • Department of Psychology
      New Haven, Connecticut, United States
  • 1993
    • University of Vermont
      • Department of Psychiatry
      Burlington, Vermont, United States
  • 1981–1993
    • University of North Carolina at Chapel Hill
      • Department of Psychology
      North Carolina, United States
  • 1992
    • The University of the West Indies at Mona
      Kingston, Kingston, Jamaica
  • 1987
    • University of Florida
      Gainesville, Florida, United States