Publications (2)7.65 Total impact
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Article: Extensive genomic polymorphism within Mycobacterium avium.
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ABSTRACT: We have initiated comparative genomic analysis of Mycobacterium avium subspecies by DNA microarray, uncovering 14 large sequence polymorphisms (LSPs) comprising over 700 kb that distinguish M. avium subsp. avium from M. avium subsp. paratuberculosis. Genes predicted to encode metabolic pathways were overrepresented in the LSPs, and analysis revealed a polymorphism within the mycobactin biosynthesis operon that potentially explains the in vitro mycobactin dependence of M. avium subsp. paratuberculosis.Journal of Bacteriology 10/2004; 186(18):6332-4. · 3.83 Impact Factor -
Article: Mutational analysis of cell wall biosynthesis in Mycobacterium avium.
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ABSTRACT: The cell wall of the environmental pathogen Mycobacterium avium is important to its virulence and intrinsic antimicrobial resistance. To identify genes involved in cell wall biosynthesis, "transposome" insertion libraries were screened for mutants with altered colony morphology on medium containing the lipoprotein stain Congo red. Nineteen such mutants were isolated and mapped, including 10 with insertions in a functional island of cell wall biosynthetic genes that spans approximately 40 kb of the M. avium genome.Journal of Bacteriology 09/2003; 185(16):5003-6. · 3.83 Impact Factor
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2003
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Seattle Institute for Biomedical and Clinical Research
Seattle, WA, USA
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