Steven V Ley,
Alessandra Antonello,
Emily P Balskus, David T Booth,
Søren B Christensen,
Ed Cleator,
Helen Gold,
Klemens Högenauer,
Udo Hünger,
Rebecca M Myers,
Steven F Oliver,
Oliver Simic,
Martin D Smith,
Helmer Søhoel,
Alison J A Woolford
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ABSTRACT: The thapsigargins are a family of complex guaianolides with potent and selective Ca(2+)-modulating properties. This article documents the evolution of a synthetic route through several iterations to a final practical and scaleable synthetic route capable of generating both unnatural and natural products based around the guaianolide skeleton.
Proceedings of the National Academy of Sciences 09/2004; 101(33):12073-8. · 9.68 Impact Factor
