Renata Orłowska-Florek

Publications of Renata Orłowska-Florek

• Kikuchi-Fujimoto disease: case report.

  Authors: Aneta Kołodziej-Kłek, Renata Orłowska-Florek, Krystyna Gałazka, Marek Grzywa

  Polskie archiwum medycyny wewnȩtrznej. 12/2009; 119(12):826-9.

  We present the case of a 27-year-old woman with local cervical lymphadenopathy without other symptoms. Due to a gradual progression of lesions, a biopsy was performed, and a specimen excised from anWe present the case of a 27-year-old woman with local cervical lymphadenopathy without other symptoms. Due to a gradual progression of lesions, a biopsy was performed, and a specimen excised from an enlarged lymph node was subjected to histological examination. Kikuchi-Fujimoto disease (KFD), that is histiocytic necrotizing lymhadenitis, was diagnosed. Lymphadenopathy resolved without medical treatment over 6 months. KFD should be considered in the differential diagnosis of lymphadenopathy, even though this disease rarely occurs in Poland.

• [Two cases of serious hepatic injury caused by antithyroid drugs.]

  Authors: Marek Grzywa, Renata Orłowska-Florek, Anna Grzywa-Celińska

  Endokrynologia Polska. 01/2009; 60(5):396-400.

  We present two cases of severe hepatotoxicity caused by antithyroid drugs in women with Graves disease. The first medication in both cases was methimazole replaced by propylhiouracil due toWe present two cases of severe hepatotoxicity caused by antithyroid drugs in women with Graves disease. The first medication in both cases was methimazole replaced by propylhiouracil due to intolerance. The main symptom was jaundice lasting about 2 months. As a first step in the treatment we terminated the antithyroid drug administration and introduced prednisone and ursodesoksycholic acid therapy. The termination of thyrotoxicosis by means of 131 I administration had also positive influence on the course of disease. In summary we emphasise the significance of prompt discontinuation of antithyroid drug once toxic symptoms appeared and avoid replacement one thyrostatic drug for another in fovour of radioiodine treatment.

• [Volume and echostructure of the thyroid and ioduria in an urban population of adults in the southeastern Polish city of Rzeszów]

  Authors: Renata Orłowska-Florek, Marek Grzywa

  Polskie archiwum medycyny wewnȩtrznej. 09/2004; 112(2):937-43.

  The aim of this work was to determine the volume and echostructure of the thyroid and to examine urinary iodine excretion in an adult population of residents of Rzeszów, a city located in theThe aim of this work was to determine the volume and echostructure of the thyroid and to examine urinary iodine excretion in an adult population of residents of Rzeszów, a city located in the Carpathian endemic region for goiter, after the introduction of mandatory iodine prophylaxis in 1997. 984 subjects, aged 19-60, were examined (540 females and 394 males). The mean level of urinary iodine in the examined population was 104.17 microg/l (+/- 85.22). Higher urinary iodine levels were seen in the group of males (p = 0.005) and in those who were taking medication containing iodine (p = 0.002). The mean volume of the thyroid in the examined group was 18.69 (+/- 10.01) ml and was larger in the group of males than females (p < 0.005). Nodular lesions were found in 17% of the examined thyroids and a statistically significant prevalence in the group of females (20.8%) over the group of males (11.4%) was found (p < 0.0005). The occurrence of nodules increased with age and was significantly higher in the 40-60 year age group than in the 19-25 years age group (p = 0.001). In single--and multi--factor analysis, a correlation was found between the occurrence of nodules and the female gender (r-2.04, 3.48; p < 0.005, < 0.0005) and the occurrence of nodules and the volume of the thyroid (r-1.1, 1.11; p < 0.005, < 0.0005). The occurrence of nodules did not correlate with ioduria (r-1, p = 0.8). Iodine prophylaxis was shown to be highly effective, although the examined region does not yet meet the criteria for the elimination of iodine deficiency as formulated by the ICCIDD.

• The rising incidence of type 1 diabetes in south-eastern Poland. A study of the 0-29 year-old age group, 1980-1999.

  Authors: Anna Sobel-Maruniak, Marek Grzywa, Renata Orłowska-Florek, Andrzej Staniszewski

  Endokrynologia Polska. 57(2):127-30.

  INTRODUCTION: Studies carried out over the last few years have provided information about the increase in the incidence of type 1 diabetes in different parts of the world including the EuropeanINTRODUCTION: Studies carried out over the last few years have provided information about the increase in the incidence of type 1 diabetes in different parts of the world including the European countries bordering Poland. THE AIM OF STUDY: The aim of this study was to determine the long-term trends in the incidence of type 1 diabetes over the 20 years between 1980 and 1999 and to compare the incidence during the decades preceding and following the 1989 economic and political transformation in Poland. MATERIAL AND METHODS: The registration of type 1 diabetes among people aged 0-29 was drawn up according to the DERI recommendations using three data sources. We calculated the age-standardised incidence rates for five-year age groups and determined the long-term trend in the incidence of type 1 diabetes in south-eastern Poland. RESULTS: A significant growth in the incidence of type 1 diabetes was observed among people aged 0-29 in the Rzeszów Province in the period between 1980 and 1999. The mean age-standardised incidence rate was 6.1/100,000, and a statistically significant difference was noted between the 1980s and the 1990s (5.3 [95%CI 4.5-6.0] and 6.8 [95%CI 5.9-7.6]). The male incidence of 6.7 significantly exceeded that for females--5.5/100,000. There was also a higher incidence in the group aged 0-14 in comparison with the group aged 15-29 (6.4 and 5.8/100,000 respectively). The highest incidence was found in boys aged 10-14 (11.5/100,000) and a significantly rising trend was observed in children of 0-4 years old. CONCLUSIONS: The mean incidence of type 1 diabetes among the study population was low. Nevertheless, we demonstrated a significantly increasing trend in the incidence during the 20-year observation period. The incidence in the 1990s, both in general and for males, was significantly higher when compared to the 1980s.