Susan McKay

Publications (2)5.38 Total impact

• Article: The synthesis of 5-substituted ring E analogs of methyllycaconitine via the Suzuki-Miyaura cross-coupling reaction.

  Junfeng Huang, Crina M Orac, Susan McKay, Dennis B McKay, Stephen C Bergmeier
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  ABSTRACT: Novel 3,5-disubstituted ring E analogs of methyllycaconitine were prepared and evaluated in nicotinic acetylcholine receptor binding assays. The desired analogs were prepared through the Suzuki-Miyaura cross-coupling reaction of methyl 5-bromo-nicotinate. The Suzuki-Miyaura cross-coupling reactions of pyridines with electron withdrawing substituents have not been extensively described previously.
  Bioorganic & medicinal chemistry 05/2008; 16(7):3816-24. · 2.82 Impact Factor
• Article: Structure activity studies of ring E analogues of methyllycaconitine. Part 2: Synthesis of antagonists to the alpha3beta4* nicotinic acetylcholine receptors through modifications to the ester.

  Stephen C Bergmeier, Khadiga A Ismail, Kristjan M Arason, Susan McKay, Darrell L Bryant, Dennis B McKay
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  ABSTRACT: The development of novel agents for the differentiation of neuronal nicotinic acetylcholine receptors (nAChRs) is important for the treatment of a variety of pathological conditions. We have prepared and evaluated a number of simpler analogues of the norditerpeniod alkaloid methyllycaconitine (MLA) in an effort to understand molecular determinants of nAChR*small molecule interactions. We have previously reported the synthesis and evaluation of a series of ring E analogues of MLA. We report here the optimization of the alpha3beta4* functional activity of this series of compounds through modification of the ester.
  Bioorganic & Medicinal Chemistry Letters 08/2004; 14(14):3739-42. · 2.55 Impact Factor