Naoki Igarashi

Publications (8)7.69 Total impact

• Article: Laparoscopy-assisted combined resection for synchronous gastric and colorectal cancer: report of three cases.

  Hideo Matsui, Yuichi Okamoto, Akiko Ishii, Kazuhiro Ishizu, Yasumasa Kondoh, Naoki Igarashi, Kyoji Ogoshi, Hiroyasu Makuuchi
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  ABSTRACT: In gastric cancer patients, the most common form of synchronous cancer is colorectal cancer. To reduce the invasiveness of the resection, a laparoscopy-assisted combined resection was performed in three patients with synchronous gastric and colorectal cancer. Although all gastric lesions were in the early stages, two colorectal lesions were advanced cases. In all cases, the laparoscopic gastric resection and reconstruction was performed first, followed by the colorectal resection. In the case of right-side colon cancer in addition to gastric cancer, it was relatively easy to perform the combined resection with lymph node dissection sharing the same ports used for the gastrectomy, although we needed an additional port. In one case, in which rectal cancer was present in addition to gastric cancer located in the upper portion of the stomach, a totally laparoscopic proximal gastrectomy was combined with a laparoscopy-assisted low anterior resection, leaving only a lower abdominal minilaparotomy wound. All patients quickly returned to normal activity without remarkable complications, with the exception of a wound infection in one patient. With a mean follow-up of 30.7 months, all patients survived without any sign of recurrence. This procedure represents a feasible option for minimally invasive treatment of synchronous gastric and colorectal cancer.
  Surgery Today 02/2009; 39(5):434-9. · 1.22 Impact Factor
• Article: LAPAROSCOPIC COMPOSITE‐MESH REPAIR OF AN ADULT MORGAGNI HERNIA

  Hideo Matsui, Osamu Itano, Naoki Igarashi, Yasumasa Koyama, Makoto Miyakita
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  ABSTRACT: Congenital Morgagni hernia is a rare clinical condition. We present a 72-year-old man with epigastric discomfort and hematemesis who was diagnosed with hernia of Morgagni with an incarceration of the stomach and colon. The patient was treated electively by laparoscopic composite-mesh repair without excising the hernial sac or approximating the edges of the defect, which was 10 × 6 cm in diameter. He was discharged on the seventh postoperative day without any complications. At a 1-year follow-up examination he had no recurrence nor clinical symptoms, although the large hernial sac contained fluid. Laparoscopic composite-mesh repair is a less-invasive and tension-free method for Morgagni hernia that results in an excellent clinical outcome.
  Digestive Endoscopy 09/2007; 19(4):185 - 188. · 1.19 Impact Factor
• Source

  Available from: u-tokai.ac.jp

  Article: Laparoscopic function-preserving surgery for early gastric cancer in the upper third of the stomach: vagus-sparing proximal gastrectomy with side-to-side esophagogastric-tube anastomosis.

  Hideo Matsui, Naoki Igarashi, Osamu Itano, Yasumasa Koyama, Makoto Miyakita
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  ABSTRACT: Proximal gastrectomy with an anti-reflux procedure has been a treatment option for gastric cancer in the upper third of the stomach. For early gastric cancer, laparoscopic function-preserving gastrectomy with limited lymphadenectomy can be performed. Objective of this study was to develop a new surgical technique for gastric cancer in the upper third of the stomach. We present here our totally laparoscopic proximal gastrectomy with vagus-sparing lymphadenectomy and gastric-tube reconstruction. Six patients (five males and one female; mean age 74 years) with gastric cancer in the upper third of the stomach underwent the procedure. Detailed operative procedure and preliminary results were presented. We have successfully performed the procedure with no conversion to open surgery. The mean operative time and blood loss were 413 minutes and 85 mL. No intraoperative and postoperative complications occurred except for reflux esophagitis in one patient. At the mean follow up of 25 months, all patients were alive without any sign of recurrence. Although long-term follow up and a larger number of patients are required to evaluate functional outcomes and oncological adequacy, our new technique provides a minimally invasive surgical option for early gastric cancer in the cardiac area.
  The Tokai journal of experimental and clinical medicine 01/2007; 32(4):109-14.
• Source

  Available from: u-tokai.ac.jp

  Article: Laparoscopy-assisted resection of an appendiceal mucinous cystadenoma.

  Hideo Matsui, Naoki Igarashi, Atsushi Okamura, Osamu Itano, Yasumasa Koyama, Makoto Miyakita
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  ABSTRACT: We present a 48-year-old man with a complaint of dull right-lower abdominal pain who was diagnosed with mucocele of the appendix. He underwent laparoscopy-assisted resection of the tumor. In the procedure, the entire right colon was freed from the retroperitoneal structures without rupturing the tumor; and ileocecal resection and anastomosis were performed extracorporeally. The pathological diagnosis of the tumor was mucinous cystadenoma of the appendix, measuring 9.0 cm × 8.0 cm × 4.0 cm. The postoperative course was uneventful, and he had no recurrent disease at a 2-year follow up. When resecting an appendiceal mucinous tumor laparoscopically, it is essential (1) to keep the tumor intact during manipulation, and to use a wound-protecting device when delivering the lesion; (2) to consider the extent of tumor resection with a negative surgical margin as well as prophylactic lymph node dissection in cases of suspected adenocarcinoma, even though the oncological adequacy of the laparoscopic procedure for carcinoma remains to be elucidated; and (3) to check whether any mucinous fluid has accumulated in the abdominal cavity, which represents an indication for open surgery.
  The Tokai journal of experimental and clinical medicine 01/2007; 32(4):140-3.
• Article: Expression of Matrix Metalloproteinases in Gastric Carcinoma and Possibility of Clinical Application of Matrix Metalloproteinase Inhibitor in Vivo

  YOSHIHIDE OTANI, TETSURO KUBOTA, YOSHIHIKO SAKURAI, NAOKI IGARASHI, TAKEYOSHI YOKOYAMA, MASARU KIMATA, NORIHITO WADA, KAORI KAMEYAMA, KOICHIRO KUMAI, YASUNORI OKADA, MASAKI KITAJIMA
  Annals of the New York Academy of Sciences 02/2006; 878(1):541 - 543. · 3.15 Impact Factor
• Article: Traumatic pulmonary pseudocyst with hemopneumothorax in a football player.

  Masazumi Watanabe, Naoki Igarashi, Masao Naruke, Hiroshi Sakihara, Koichi Kobayashi
  Clinical Journal of Sport Medicine 02/2005; 15(1):41-3. · 2.12 Impact Factor
• Article: [A case of advanced gastric cancer with a tumor embolus in the portal vein successfully treated with TS-1 and CDDP].

  Sojun Hoshimoto, Jun Hagiuda, Naoki Igarashi, Hideo Matsui, Yasumasa Koyama, Makoto Miyakita, Shoji Takanosu
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  ABSTRACT: A 71-year-old man was admitted to our hospital in February 2002 with a diagnosis of advanced gastric cancer with a tumor embolus in the portal vein. TS-1 (120 mg/day) was administered orally daily for 21 days, and CDDP (90 mg/day) was infused intravenously on day 8. After 1 course of this regimen, medication was discontinued in accordance with the patient's request. The patient was readmitted with a history of tarry stools in July 2003. Despite no cancer treatment for almost 1.5 years, the primary lesion and the metastatic lymph nodes had decreased significantly in size and the tumor embolus in the portal vein had disappeared completely on the CT scan. He was therefore treated with TS-1 alone (120 mg/day) under a 4-weeks-on and 2-weeks-off regimen. After 1 course of TS-1 administered alone, the primary lesion showed a further significant decrease in size as viewed by GI endoscopy, and biopsies did not reveal any evidence of malignancy.
  Gan to kagaku ryoho. Cancer & chemotherapy 08/2004; 31(7):1079-81.
• Article: Matrix metalloproteinase inhibitor, marimastat, decreases peritoneal spread of gastric carcinoma in nude mice.

  Masaru Kimata, Yoshihide Otani, Tetsuro Kubota, Naoki Igarashi, Takeyoshi Yokoyama, Norihito Wada, Nobunari Yoshimizu, Masato Fujii, Kaori Kameyama, Yasunori Okada, Koichiro Kumai, Masaki Kitajima
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  ABSTRACT: Marimastat, a matrix metalloproteinese inhibitor, was examined for the ability to prevent peritoneal dissemination of a human gastric cancer xenograft, TMK-1. Even with novel approaches such as molecular targeting of cancer chemotherapy, peritoneal dissemination of gastric cancer has little sensitivity to anticancer drugs, and it is impossible to inhibit its growth completely. Intraperitoneal injection of TMK-1 into nude mice at 5 x 10( 5) cells / body resulted in carcinomatous peritonitis that mimicked clinical cases. Continuous administration of marimastat (18 mg / kg / day) from 24 h after the tumor inoculation successfully inhibited the growth of peritoneal dissemination nodules. Combined administration of marimastat (18 mg / kg / day) and mitomycin C (MMC, 2 mg / kg) showed synergistic inhibition of growth of peritoneal dissemination, being superior to MMC alone (2 mg / kg). Although marimastat alone could not increase survival time with statistical significance, combined administration of marimastat and MMC had a survival benefit with statistical significance. The combination of marimastat and MMC increased the preventive effect on peritoneal dissemination. Marimastat seems to be a candidate for the prevention of peritoneal spread of gastric carcinoma.
  Japanese journal of cancer research: Gann 08/2002; 93(7):834-41.