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ABSTRACT: Six new dammarane glycosides (1-6) and four known compounds, rutin, kaempferol, quercetin, and linalool 3-O-beta-D-glucopyranoside, were isolated from an ethanol extract of the aerial parts of Gynostemma cardiospermum. The structures of 1-6 were elucidated by 1D and 2D NMR spectroscopic interpretation as well as by chemical degradation. Triterpene aglycons containing carbonyl groups at both C-21 and C-28, as found in compounds 1-5, are being reported in the family Cucurbitaceae for the first time.
Journal of Natural Products 11/2006; 69(10):1394-8. · 3.13 Impact Factor
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ABSTRACT: Nine new dammarane saponins, 1-9, were isolated from the MeOH extract of the aerial part of Gynostemma pentaphyllum, an edible plant of the Cucurbitaceae family, that grows wildly in China. Their structures were elucidated by 1D- and 2D-NMR analysis, as well as by chemical degradation. Aglycons 21,24-cyclopentyldammar-25-ene of 6 and 7, and 21,24-cyclopentyldammarane of 8 and 9, were novel. Compounds 1, 4, and 8 showed moderate antitumor activities against stomach cancer cells SGC-7901 and liver cancer cells BEL-7402.
Chemistry & Biodiversity 08/2006; 3(7):771-82. · 1.80 Impact Factor
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ABSTRACT: Three new compounds designated as firmianones A, B, and C (1-3), along with 13 known compounds, were isolated from the roots of Firmiana platanifolia. Their structures were elucidated by interpretation of HRESIMS, 1H-1H COSY, HMQC, HMBC, and NOESY. The absolute configurations of firmianones A and B with a rare hexacyclic skeleton were determined by CD exciton-coupling experiments. Firmianones A and B exhibited moderate cytotoxicity to the P388 cancer cell line.
Journal of Natural Products 09/2005; 68(8):1159-63. · 3.13 Impact Factor
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ABSTRACT: The six new triterpene saponins 1–6 with a 21,23-lactone skeleton were isolated from the MeOH extract of the aerial parts of Gynostemma pentaphyllum. Their structures were elucidated by 1D- and 2D-NMR-spectra interpretation as well as by chemical degradation.
Helvetica Chimica Acta 05/2005; 88(5):1126 - 1134. · 1.48 Impact Factor
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ABSTRACT: Three new dammarane glycosides (1-3), together with five known compounds, gypenoside LXIX (4), gylongiposide I (5), gypenoside XLVIII (6), allantion (7) and vitexin (8) were isolated from the MeOH extract of the aerial parts of Gynostemma pentaphyllum. Compounds 5, 7, and 8 were isolated from this plant for the first time. Their structures were elucidated by 1D and 2D NMR spectra interpretation as well as by chemical degradation.
CHEMICAL & PHARMACEUTICAL BULLETIN 01/2005; 52(12):1440-4. · 1.59 Impact Factor
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ABSTRACT: Xanthones, 1,3-dihydroxy-5-methoxyxanthone-4-sulfonate and 1,3-dihydroxy-5-O-beta-D-glycopyranosylxanthone-4-sulfonate, together with nine known compounds were obtained from H. sampsonii. This is the first report of sulfonated xanthonoids. Furthermore, compounds 1 and 2 exhibited significant cytotoxicity against the P388 cancer cell line.
Phytochemistry 10/2004; 65(18):2595-8. · 3.35 Impact Factor
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ABSTRACT: Fifteen new dammarane glycosides (1-15), together with four known compounds, gypenosides IV, VIII, LXXI, and XLIX, were isolated from the MeOH extract of the aerial parts of Gynostemma pentaphyllum. Their structures were elucidated by 1D and 2D NMR spectra interpretation as well as by chemical degradation.
Journal of Natural Products 07/2004; 67(6):942-52. · 3.13 Impact Factor
